Diamine Oxidase and Gastrointestinal Diseases [PDF]
BiomoleculesHistamine plays an essential role in gastrointestinal physiology and immune control, while its balance in the intestinal environment is largely maintained through degradation by diamine oxidase (DAO), a copper-dependent enzyme mainly produced by ...
Paulina Żybul +3 more
doaj +3 more sources
Evaluation of Serum Diamine Oxidase as a Diagnostic Test for Histamine Intolerance [PDF]
Nutrients, 2023 Histamine intolerance (HIT) is a clinical condition caused by decreased intestinal degradation of ingested histamine, primarily due to reduced enzyme diamine oxidase (DAO) activity, leading to histamine accumulation and causing various clinical ...
Matija Rijavec, Mitja Kosnik
exaly +3 more sources
Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain. [PDF]
Biomedicines, 2023 Diamine oxidase (DAO) is an enzyme that metabolizes intestinal histamine. Single nucleotide polymorphisms (SNPs) of the Amine Oxidase Copper Containing 1 (AOC1) gene can lead to low enzymatic activity or functionality in histamine metabolism.
Okutan G +8 more
europepmc +3 more sources
The Rate of Histamine Degradation by Diamine Oxidase Is Compromised by Other Biogenic Amines. [PDF]
Front Nutr, 2022 Nowadays, certain uncertainties related to the onset of histamine adverse effects remain unsolved and still require further research. Questions still to be resolved include the wide range of doses at which dietary histamine may trigger symptoms of ...
Sánchez-Pérez S +6 more
europepmc +2 more sources
Toward Oral Supplementation of Diamine Oxidase for the Treatment of Histamine Intolerance. [PDF]
Nutrients, 2022 A new diamine oxidase (DAO-1) was discovered recently in the yeast Yarrowia lipolytica PO1f and investigated for its histamine degradation capability under simulated intestinal conditions.
Kettner L, Seitl I, Fischer L.
europepmc +2 more sources
Elevated serum levels of diamine oxidase, D-lactate and lipopolysaccharides are associated with metabolic-associated fatty liver disease. [PDF]
Eur J Gastroenterol Hepatol, 2023 Background Studies have suggested an association between metabolic-associated fatty liver disease (MAFLD) and intestinal barrier function. The present study aims to investigate the association between MAFLD and intestinal barrier impairment in humans and
Zhang R, Chen YN, Zhang J, Liu J.
europepmc +2 more sources
Basal Serum Diamine Oxidase Levels as a Biomarker of Histamine Intolerance: A Retrospective Cohort Study. [PDF]
Nutrients, 2022 Background: Histamine Intolerance (HIT) is a multifaceted pseudoallergic disorder possibly due to defective histamine metabolism. Diamine oxidase (DAO) contributes to histamine degradation and can be measured in the serum.
Cucca V +9 more
europepmc +2 more sources
Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles
Scientific Reports, 2020 Excess of histamine in gut lumen generates a pronounced gastrointestinal discomfort, which may include diarrhea and peristalsis dysfunctions. Deleterious effects of histamine can be alleviated with antihistamine drugs targeting histamine receptors ...
Armelle Tchoumi Neree +5 more
doaj +2 more sources
Serum diamine oxidase as a hemorrhagic shock biomarker in a rabbit model. [PDF]
PLoS ONE, 2014 BACKGROUND: In prolonged hemorrhagic shock, reductions in intestinal mucosal blood perfusion lead to mucosal barrier damage and systemic inflammation.
Liang Zhao +7 more
doaj +2 more sources
Diamine Oxidase-Conjugated Multiwalled Carbon Nanotubes to Facilitate Electrode Surface Homogeneity [PDF]
Sensors, 2022 Carbon nanomaterials have gained significant interest over recent years in the field of electrochemistry, and they may be limited in their use due to issues with their difficulty in dispersion.
M. Amin +6 more
doaj +2 more sources