Results 1 to 10 of about 283 (130)
Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1–9) or methoctramine (10–14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and ...
Manuela Cervelli +2 more
exaly +6 more sources
Antioxidants, 2022 Metabolism and regulation of cellular polyamine levels are crucial for living cells to maintain their homeostasis and function. Polyamine oxidases (PAOs) terminally catabolize polyamines or catalyse the back-conversion reactions when spermine is ...
Attila Feher, Peter Benko
exaly +6 more sources
Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration
Frontiers in Neuroscience, 2019 Dysfunction of retinal neurons is a major cause of vision impairment in blinding diseases that affect children and adults worldwide. Cellular damage resulting from polyamine catabolism has been demonstrated to be a major player in many neurodegenerative ...
Chithra Devi Palani +2 more
exaly +3 more sources
Improvment of cold tolerance of chickpea through heavy polyamines catabolism and ethylene phytohormone [PDF]
مجله بیوتکنولوژی کشاورزی, 2023 Objective The current study was undertaken to investigate if there is a relationship between metabolism of ethylene and heavy polyamines (PAs) under cold stress in cold-tolerant and cold-sensitive chickpea (Cicer arietinum L.) genotypes.
Saeed Amini +2 more
doaj +1 more source
Journal of Agricultural Sciences, 2022 The relationship between hydrogen peroxide and the metabolism of polyamines and the role of NADPH oxidase (NOX) in that relationship under drought conditions remains unclear.
Aykut Sağlam +3 more
doaj +1 more source
The tree of life of polyamine oxidases [PDF]
Scientific Reports, 2020 AbstractPolyamine oxidases (PAOs) are characterized by a broad variability in catalytic properties and subcellular localization, and impact key cellular processes in diverse organisms. In the present study, a comprehensive phylogenetic analysis was performed to understand the evolution of PAOs across the three domains of life and particularly within ...
Salvi D., Tavladoraki P.
openaire +4 more sources
Biomedicines, 2023 The relationship between polyamines and healthy longevity has received much attention in recent years. However, conducting research without understanding the properties of polyamines can lead to unexpected pitfalls.
Kuniyasu Soda
doaj +1 more source
Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats [PDF]
The Ukrainian Biochemical Journal, 2016 In this study we have tested an idea on the important role of amine oxidases (semicarbazide-sensitive amine oxidase, diamine oxidase, polyamine oxidase) as an additional source of oxidative/carbonyl stress under glycerol-induced rhabdomyolysis, since the
O. O. Gudkova +2 more
doaj +1 more source
Biomolecules, 2023 The triamine spermidine is a key metabolite of the polyamine pathway. It plays a crucial role in many infectious diseases caused by viral or parasitic infections.
Annette Kaiser
doaj +1 more source
Frontiers in Pharmacology, 2020 Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation ...
Freddy López-Contreras +9 more
doaj +1 more source