Results 1 to 10 of about 57,007 (201)
Dietary Spermidine Improves Cognitive Function [PDF]
Cell Reports, 2021 Summary: Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood.
Dídac Carmona-Gutierrez +2 more
exaly +7 more sources
Poultry Science, 2023 : Spermidine have been reported a role in antioxidative, antiaging, and antiinflammatory. Oxidative stress causes granulosa cell (GC) apoptosis, follicular atresia, and impairs poultry reproductive functions.
Dongmei Jiang +10 more
doaj +2 more sources
Free spermidine evokes superoxide radicals that manifest toxicity
eLife, 2022 Spermidine and other polyamines alleviate oxidative stress, yet excess spermidine seems toxic to Escherichia coli unless it is neutralized by SpeG, an enzyme for the spermidine N-acetyl transferase function. Thus, wild-type E.
Vineet Kumar +10 more
doaj +1 more source
Fisheries and Aquatic Sciences, 2023 Auranofin is a US Food and Drug Administration (FDA)-approved anti-arthritis medication that functions as a thioredoxin reductase inhibitor. Spermidine, a polyamine present in marine algae, can exert various physiological functions.
Hyun Hwangbo +7 more
doaj +1 more source
The effect of spermidine on autoimmunity and beta cell function in NOD mice
Scientific Reports, 2022 Spermidine is a natural polyamine which was shown to prolong lifespan of organisms and to improve cardiac and cognitive function. Spermidine was also reported to reduce inflammation and modulate T-cells. Autophagy is one of the mechanisms that spermidine
Ceren Karacay +15 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2022 Background: Polyamines have been demonstrated to be beneficial to porcine intestinal development. Our previous study showed that putrescine mitigates intestinal atrophy in weanling piglets and suppresses inflammatory response in porcine intestinal ...
Zi-xi Wei +4 more
doaj +1 more source
Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis
Communications Biology, 2023 Kidney metabolism may be greatly altered in chronic kidney disease. Here we report that arginine metabolism is the most altered in unilateral ureteral obstruction (UUO)-induced fibrosis of the kidneys in metabolomic analysis.
Seishi Aihara +5 more
doaj +1 more source
Metabolites, 2022 Microbiota-derived metabolites have biological importance for their host. Spermidine, a metabolite described for its protective effect in age-related diseases, is now studied for its role in the resolution of inflammation and gut homeostasis.
Clément Caffaratti +4 more
doaj +1 more source
Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study
Frontiers in Nutrition, 2022 The relationship between serum spermidine levels and future cardiovascular disease risk has not yet been well elucidated in the general population based on community studies.
Liqiang Zheng +19 more
doaj +1 more source
Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
Open Life Sciences, 2021 Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine ...
Jiang Dongmei +3 more
doaj +1 more source