Results 41 to 50 of about 57,007 (201)

Regulating T-cell differentiation through the polyamine spermidine [PDF]

, 2020
Background The cross-talk between the host and its microbiota plays a key role in the promotion of health. The production of metabolites such as polyamines by intestinal-resident bacteria is part of this symbiosis shaping host immunity.
Marc Lindenberg, Luís Almeida, Guilhermina M. Carriche, Stüve, P., Anna Katharina Simon, Roy, U., Dhillon-LaBrooy, A., Plaza-Sirvent, C., Carriche, G.M., Urmi Roy, Lochner, M., Lindenberg, M., Tim Sparwasser, Strowig, T., Philipp Stüve, Matthias Lochner, Till Strowig, Ingo Schmitz, Lis Velasquez, Sparwasser, T., Ayesha Dhillon-LaBrooy, Velasquez, L., Simon, A.K., Schmitz, I., Almeida, L., Carlos Plaza-Sirvent   +25 more
core   +1 more source

Genome‐Wide and Multi‐Omics Analysis Identified DNA‐Interacting Circular RNA circFOXK2 as MLL1 Regulator for Histone H3K4 Methylation in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Circular RNA circFOXK2 is frequently upregulated in pancreatic ductal adenocarcinoma to promote tumor heterogeneity, growth, and metastasis. Through circRNA‐DNA interaction at different genomic locations, circFOXK2 removes the PPIE inhibitory effects on MLL1 for gene‐activating H3K4 methylation of the oncogenes.
Chi Hin Wong, Jessica Jazmin Peña‐Paladines, Sum Yin Valerie Leung, Ka‐Fai To, Kenneth Siu Ho Chok, Yangchao Chen   +5 more
wiley   +1 more source

Effect of exogenous spermidine on expression profile of reproductive hormone receptors in mouse ovaries

浙江大学学报. 农业与生命科学版, 2017
The polyamines spermidine and spermine and their precursor putrescine are a class of compounds containing two or more amino groups and participate in the regulation of various physiological and pathological processes by interacting with negatively ...
LONG Shiyun, JIANG Dongmei, CHEN Ziyu, GUAN Cheng, YI Zhixin, KANG Bo   +5 more
doaj   +1 more source

Spermidine Suppresses Development of Experimental Abdominal Aortic Aneurysms

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The protective effects of polyamines on cardiovascular disease have been demonstrated in many studies. However, the roles of spermidine, a natural polyamine, in abdominal aortic aneurysm (AAA) disease have not been studied.
Shuai Liu, Tingting Huang, Rui Liu, Huoying Cai, Baihong Pan, Mingmei Liao, Pu Yang, Lei Wang, Jianhua Huang, Yingbin Ge, Baohui Xu, Wei Wang   +11 more
doaj   +1 more source

Spermidine

, 2002
Inelastic Neutron Scattering spectrum of Spermidine, H₂N(CH₂)₃NH(CH₂)₃NH₂, measured on the TOSCA ...
M. P. M. Marques, Universidade de Coimbra, Portugal
core   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Non-linear associations of serum spermidine with type 2 diabetes mellitus and fasting plasma glucose: a cross-sectional study

Frontiers in Nutrition
BackgroundPrevious animal experiments have demonstrated the potential of spermidine to mitigate glucose intolerance, insulin resistance, and hyperinsulinemia.
Xiaohong Zhang, Xiaohong Zhang, Xiaohong Zhang, Yao Zhang, Shaojie Li, Min Liu, Ying Lu, Mengyao He, Zhaoqing Sun, Mingfeng Ma, Liqiang Zheng, Liqiang Zheng, Liqiang Zheng, Liqiang Zheng   +13 more
doaj   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Mitigation of salinity stress in yarrow (Achillea millefolium L.) plants through spermidine application.

PLoS ONE
This study investigated the mitigating effects of spermidine on salinity-stressed yarrow plants (Achillea millefolium L.), an economically important medicinal crop.
Sajedeh Alijani, Mohammad-Reza Raji, Zohreh Emami Bistgani, Abdollah Ehtesham Nia, Mostafa Farajpour   +4 more
doaj   +1 more source

Spermidine induced aggregation of terphenyl derivative: An efficient probe for detection of spermidine in living cells

, 2018
A terphenyl derivative 3 has been designed and synthesized which undergoes self-assembly in mixed aqueous media to form weakly emissive aggregates.
Manoj Kumar, Tejpal, Ruchi, Ruchi Tejpal, Bhalla, Vandana, Vandana Bhalla, Kumar, Manoj   +5 more
core   +1 more source