Results 21 to 30 of about 92,235 (298)

Free spermidine evokes superoxide radicals that manifest toxicity

eLife, 2022
Spermidine and other polyamines alleviate oxidative stress, yet excess spermidine seems toxic to Escherichia coli unless it is neutralized by SpeG, an enzyme for the spermidine N-acetyl transferase function. Thus, wild-type E.
Vineet Kumar, Rajesh Kumar Mishra, Debarghya Ghose, Arunima Kalita, Pulkit Dhiman, Anand Prakash, Nirja Thakur, Gopa Mitra, Vinod D Chaudhari, Amit Arora, Dipak Dutta   +10 more
doaj   +1 more source

Auranofin accelerates spermidine-induced apoptosis via reactive oxygen species generation and suppression of PI3K/Akt signaling pathway in hepatocellular carcinoma

Fisheries and Aquatic Sciences, 2023
Auranofin is a US Food and Drug Administration (FDA)-approved anti-arthritis medication that functions as a thioredoxin reductase inhibitor. Spermidine, a polyamine present in marine algae, can exert various physiological functions.
Hyun Hwangbo, Da Hye Kim, Min Yeong Kim, Seon Yeong Ji, EunJin Bang, Su Hyun Hong, Yung Hyun Choi, JaeHun Cheong   +7 more
doaj   +1 more source

Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis

Journal of Crohn's & Colitis, 2023
Background and Aims Exacerbated immune activation, intestinal dysbiosis and a disrupted intestinal barrier are common features among inflammatory bowel disease [IBD] patients.
A. Niechcial, M. Schwarzfischer, M. Wawrzyniak, K. Atrott, A. Laimbacher, Y. Morsy, E. Katkeviciutė, J. Häfliger, Patrick Westermann, C. Akdis, M. Scharl, M. Spalinger   +11 more
semanticscholar   +1 more source

The effect of spermidine on autoimmunity and beta cell function in NOD mice

Scientific Reports, 2022
Spermidine is a natural polyamine which was shown to prolong lifespan of organisms and to improve cardiac and cognitive function. Spermidine was also reported to reduce inflammation and modulate T-cells. Autophagy is one of the mechanisms that spermidine
Ceren Karacay, Barbara Prietl, Clemens Harer, Barbara Ehall, Christoph W. Haudum, Kaddour Bounab, Joakim Franz, Tobias Eisenberg, Frank Madeo, Dagmar Kolb, Kerstin Hingerl, Markus Hausl, Christoph Magnes, Selma I. Mautner, Petra Kotzbeck, Thomas R. Pieber   +15 more
doaj   +1 more source

Spermidine - an old molecule with a new age-defying immune function.

Trends in Cell Biology, 2023
Polyamines - putrescine, spermidine, and spermine - are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells.
K. Chamoto, Baihao Zhang, Masaki Tajima, Tasuku Honjo, S. Fagarasan   +4 more
semanticscholar   +1 more source

Bioengineering of Escherichia coli Nissle 1917 for Production and Excretion of Spermidine, a Key Metabolite in Human Health

Metabolites, 2022
Microbiota-derived metabolites have biological importance for their host. Spermidine, a metabolite described for its protective effect in age-related diseases, is now studied for its role in the resolution of inflammation and gut homeostasis.
Clément Caffaratti, Caroline Plazy, Valérie Cunin, Bertrand Toussaint, Audrey Le Gouellec   +4 more
doaj   +1 more source

Tumor cell–derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8+ T cell activation

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance A hallmark of tumor growth is the formation of immunosuppressive tumor milieu termed tumor immune microenvironment (TIME). Tumors create a favorable environment for their own propagation by expressing or releasing immunosuppressive molecules.
Sana Hibino, Shotaro Eto, S. Hangai, Keiko Endo, Sanae Ashitani, Maki Sugaya, T. Osawa, T. Soga, T. Taniguchi, H. Yanai   +9 more
semanticscholar   +1 more source

Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein

International Journal of Molecular Sciences, 2023
Abnormal tau build-up is a hallmark of Alzheimer’s disease (AD) and more than 20 other serious neurodegenerative diseases. Mitochondria are paramount organelles playing a predominant role in cellular bioenergetics, namely by providing the main source of ...
L. Fairley, I. Lejri, A. Grimm, A. Eckert   +3 more
semanticscholar   +1 more source

Effects of Spermidine on Cell Proliferation, Migration, and Inflammatory Response in Porcine Enterocytes

Frontiers in Bioscience-Landmark, 2022
Background: Polyamines have been demonstrated to be beneficial to porcine intestinal development. Our previous study showed that putrescine mitigates intestinal atrophy in weanling piglets and suppresses inflammatory response in porcine intestinal ...
Zi-xi Wei, Long Cai, Xue-mei Zhao, Xian-ren Jiang, Xi-long Li   +4 more
doaj   +1 more source

Exploration of the Antioxidant Effect of Spermidine on the Ovary and Screening and Identification of Differentially Expressed Proteins

International Journal of Molecular Sciences, 2023
Spermidine is a naturally occurring polyamine compound that has many biological functions, such as inducing autophagy and anti-inflammatory and anti-aging effects. Spermidine can affect follicular development and thus protect ovarian function.
D. Jiang, Yong Guo, Chunyang Niu, Shi Long, Yilong Jiang, Zelong Wang, X. Wang, Qian Sun, W. Ling, X. An, C. Ji, Hua Zhao, B. Kang   +12 more
semanticscholar   +1 more source