Results 21 to 30 of about 52,673 (252)

Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions [PDF]

, 2011
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Sugawara Koji, Koji, Bakar, Mohd Hilmi Abu, Philpott, Michael P., Tiede Stephan, Stephan, Harrison, Wesley, Ramot Yuval, Yuval, Koji Sugawara, Wesley Harrison, Tiede, Stephan, Ramot, Y, Ramot Yuval, Paus Ralf, Paus, R, Pietilä, Marko, Tiede, S, Michael P Philpott, Harrison Wesley, Paus, Ralf, Philpott Michael P., Harrison, W, Marko Pietilä, Mohd Hilmi Abu Bakar, Abu Bakar Mohd Hilmi, Philpott, Michael P, Pietilä Marko, Abu Bakar, MH, Abu Bakar, Mohd Hilmi, Sugawara, K, Ralf Paus, Stephan Tiede, Yuval Ramot, Sugawara Koji, Bíró, Tamás, Sugawara, Koji, Tamás Bíró, Philpott, MP, Pietila, M, Michael P. Philpott, Ramot, Yuval, Tiede Stephan, Bíró Tamás, Biro, T   +41 more
core   +1 more source

Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms

Frontiers in Chemistry, 2023
Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties.
Parteek Prasher, Mousmee Sharma, Sachin Kumar Singh, Sachin Kumar Singh, Monica Gulati, Monica Gulati, Dinesh Kumar Chellappan, Rashi Rajput, Rashi Rajput, Gaurav Gupta, Gaurav Gupta, Alibek Ydyrys, Marzhan Kulbayeva, Ahmad Faizal Abdull Razis, Ahmad Faizal Abdull Razis, Babagana Modu, Babagana Modu, Javad Sharifi-Rad, Kamal Dua, Kamal Dua   +19 more
doaj   +1 more source

Alleviation of low-irrigation effects on chickpea (Cicer arietinum L.) using spermidine [PDF]

پژوهش‌های حبوبات ایران, 2020
IntroductionChickpea is one of the pulse crops and its protein percent is about 22 to 24 percent. Therefore it plays an important nutritional role in human being diet.
Vahid Sharifi, Manouchehr Gholipoor, Hamid Abbasdokht   +2 more
doaj   +1 more source

Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice

Gut Microbes, 2020
Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important benefits in patients with aging-associated diseases and metabolic dysfunction ...
Lingyan Ma, Yinhua Ni, Zhe Wang, Wenqing Tu, Liyang Ni, Fen Zhuge, Aqian Zheng, Luting Hu, Yufeng Zhao, Liujie Zheng, Zhengwei Fu   +10 more
doaj   +1 more source

Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine [PDF]

Biochemical Journal, 1987
Polyamine biosynthesis in intact cells can be exquisitely controlled with exogenous polyamines through the regulation of rate-limiting biosynthetic enzymes, particularly ornithine decarboxylase (ODC). In an attempt to exploit this phenomenon as an antiproliferative strategy, certain polyamine analogues have been identified [Porter, Cavanaugh, Stolowich,
C W, Porter, F G, Berger, A E, Pegg, B, Ganis, R J, Bergeron   +4 more
openaire   +2 more sources

Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats

, 2020
Let alone calorie restriction, life span extension in higher organisms has proven to be difficult to achieve using simple drugs. Previous studies have shown that the polyamine spermidine increased the maximum life span in C.
Popa-Wagner, A, Filfan, M, Olaru, A, Margaritescu, C, Udristoiu, I, Petcu, E, Hermann, DM   +6 more
core   +1 more source

Elucidating Immune Cell Mediated Causal Pathways Linking Blood Metabolites to Major Depressive Disorder: A Mediation Mendelian Randomization Analysis. [PDF]

Brain Behav
Our integrative Mendelian randomization framework revealed that specific circulating metabolites exert causal effects on major depressive disorder, partly through immune‐cell–mediated pathways. These findings highlight metabolite–immune interactions as potential mechanistic targets for MDD prevention and therapy.
Xu Z, Zhou Y, Zhang X, Chen X, Li Y, Wang J, Chang T, Yuan Z, Jia H.   +8 more
europepmc   +2 more sources

Enhanced shoot regeneration in nine Australian wheat cultivars by spermidine and water stress treatments [PDF]

, 2001
The regeneration potential of ageing calli initiated from isolated scutella of immature embryos was increased in nine elite Australian cultivars (QT7208, QT9685, QT7709, Kennedy, Lang, Sunvale, Giles, Petrie and Veery) of wheat (Triticum aestivum L ...
Khanna, Harjeet Kaur, Daggard, Grant E., Khanna, Harjeet K.   +2 more
core   +1 more source

Whole Blood Spermine/Spermidine Ratio as a New Indicator of Sarcopenia Status in Older Adults

Biomedicines, 2023
Early diagnosis and therapeutic intervention improve the quality of life and prognosis of patients with sarcopenia. The natural polyamines spermine and spermidine are involved in many physiological activities.
Hidenori Sanayama, Kiyonori Ito, Susumu Ookawara, Takeshi Uemura, Yoshio Sakiyama, Hitoshi Sugawara, Kaoru Tabei, Kazuei Igarashi, Kuniyasu Soda   +8 more
doaj   +1 more source

The Protective Effect of Topical Spermidine on Dry Eye Disease with Retinal Damage Induced by Diesel Particulate Matter2.5

Pharmaceutics, 2021
Air pollutants, especially ambient fine particulate matter2.5, may contribute to various ocular surface disorders, including dry eye disease, keratitis and conjunctivitis.
Hyesook Lee, Da Hye Kim, Hyun Hwangbo, So Young Kim, Seon Yeong Ji, Min Yeong Kim, Jung-Hyun Shim, Sun-Hee Leem, Jin Won Hyun, Gi-Young Kim, Yung Hyun Choi   +10 more
doaj   +1 more source