Spermidine cures yeast of prions [PDF]
Microbial Cell, 2016 Prions are self-perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals. The molecular basis underlying their conversion from a normally soluble protein into the prion form remains largely unknown. Studies aimed at uncovering these mechanism(s) are therefore essential if we are to develop effective ...
Shaun H. Speldewinde, Chris M. Grant
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Natural Polyamine Spermidine Inhibits the In Vitro Oxidation of LDL
MoleculesSpermidine is a natural autophagy-inducer and anti-aging compound. Herein, we investigated a potential autophagy-independent mechanism of spermidine, namely its capability to directly impede LDL oxidation, an early step in atherogenesis.
Christine Rossmann +9 more
doaj +2 more sources
Research Progress and Potential Applications of Spermidine in Ocular Diseases
Pharmaceutics, 2022 Spermidine, a natural polyamine, exists in almost all human tissues, exhibiting broad properties like anti-aging, autophagy induction, anti-inflammation, anti-oxidation, cell proliferation activation, and ion channel regulation.
Wentao Han, Haoyu Li, Baihua Chen
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Spermidine Modify Antioxidant Activity in Cucumber Exposed to Salinity Stress
Agronomy, 2022 The effects of short-term 48 h long NaCl-stress and spermidine level modification on polyamines level and antioxidant status in cucumber (Cucumis sativus cv. Dar) leaves were investigated.
Agata Korbas +3 more
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Molecular targets of spermidine: implications for cancer suppression
Cell Stress, 2023 Spermidine is a ubiquitous, natural polyamine with geroprotective features. Supplementation of spermi-dine extends the lifespan of yeast, worms, flies, and mice, and dietary spermidine intake correlates with reduced human mortality.
Andreas Zimmermann +2 more
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Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study. [PDF]
Aging CellCan we boost vaccine responses in older adults? In a double‐blind, randomised, placebo‐controlled pilot study (n = 40, > 65 years), spermidine supplementation (6 mg/day, 13 weeks) was safe and significantly improved immune responses following a 3rd SARS‐CoV‐2 vaccine dose.
Alsaleh G +25 more
europepmc +2 more sources
Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study
Frontiers in Nutrition, 2022 The relationship between serum spermidine levels and future cardiovascular disease risk has not yet been well elucidated in the general population based on community studies.
Liqiang Zheng +19 more
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Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2. [PDF]
PLoS ONE, 2014 Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2.
Kyohei Higashi +8 more
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Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
Open Life Sciences, 2021 Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine ...
Jiang Dongmei +3 more
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Spermidine Is an Intercellular Signal Modulating T3SS Expression in Pseudomonas aeruginosa
Microbiology Spectrum, 2022 Pseudomonas aeruginosa is a vital opportunistic human bacterial pathogen that causes acute and chronic infections. In this study, we set to determine whether the endogenous spermidine biosynthesis plays a role in regulation of type III secretion system ...
Qiqi Lin +9 more
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