Results 11 to 20 of about 57,007 (201)

SAT1-Induced Spermidine Depletion Potentiates Food Allergy. [PDF]

Adv Sci (Weinh)
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Liu M, Zhang B, Wang J, Jiang Y, Han S, Wang Q, Zeng L, Wang J, Che H.   +8 more
europepmc   +2 more sources

Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms [PDF]

Frontiers in Chemistry, 2023
Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties.
Parteek Prasher, Mousmee Sharma, Sachin Kumar Singh, Sachin Kumar Singh, Monica Gulati, Monica Gulati, Dinesh Kumar Chellappan, Rashi Rajput, Rashi Rajput, Gaurav Gupta, Gaurav Gupta, Alibek Ydyrys, Marzhan Kulbayeva, Ahmad Faizal Abdull Razis, Ahmad Faizal Abdull Razis, Babagana Modu, Babagana Modu, Javad Sharifi-Rad, Kamal Dua, Kamal Dua   +19 more
doaj   +4 more sources

Natural Polyamine Spermidine Inhibits the In Vitro Oxidation of LDL

Molecules
Spermidine is a natural autophagy-inducer and anti-aging compound. Herein, we investigated a potential autophagy-independent mechanism of spermidine, namely its capability to directly impede LDL oxidation, an early step in atherogenesis.
Christine Rossmann, Azra Darko, Gerd Kager, Gerhard Ledinski, Willibald Wonisch, Thomas Wagner, Seth Hallström, Gilbert Reibnegger, Margret Paar, Gerhard Cvirn   +9 more
doaj   +2 more sources

Spermidine Modify Antioxidant Activity in Cucumber Exposed to Salinity Stress

Agronomy, 2022
The effects of short-term 48 h long NaCl-stress and spermidine level modification on polyamines level and antioxidant status in cucumber (Cucumis sativus cv. Dar) leaves were investigated.
Agata Korbas, Jan Kubiś, Magdalena Rybus-Zając, Tamara Chadzinikolau   +3 more
doaj   +2 more sources

Whole Blood Spermine/Spermidine Ratio as a New Indicator of Sarcopenia Status in Older Adults

Biomedicines, 2023
Early diagnosis and therapeutic intervention improve the quality of life and prognosis of patients with sarcopenia. The natural polyamines spermine and spermidine are involved in many physiological activities.
Hidenori Sanayama, Kiyonori Ito, Susumu Ookawara, Takeshi Uemura, Yoshio Sakiyama, Hitoshi Sugawara, Kaoru Tabei, Kazuei Igarashi, Kuniyasu Soda   +8 more
doaj   +2 more sources

Functional Characterization of the P‐Type ATPases ATP13A3 and ATP13A4 as Plasma Membrane Polyamine Transporters [PDF]

FASEB J
ATP13A3 and ATP13A4 mediate the plasma membrane uptake of the polyamines, putrescine and spermidine, in an ATP‐dependent manner. ATP13A3 is broadly expressed across human tissues, whereas ATP13A4 is expressed at relatively high levels in the brain and lung.
Morimoto H, Yasujima T, Yamasaki M, Yamashiro T, Yuasa H.   +4 more
europepmc   +2 more sources

EBV-Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma. [PDF]

Adv Sci (Weinh)
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Li Y, Hu X, Yang C, Liu N, Wang L, Cai X, Tang M, Cao Y, Shang L, Shi F.   +9 more
europepmc   +2 more sources

Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition [PDF]

, 2014
Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms.
Didac Carmona-Gutierrez, Carmona-Gutierrez Didac, Terry K Smith, Rockenfeller Patrick, Minois Nadège, Smith Terry K., Terry K. Smith (112550), Patrick Rockenfeller, Rockenfeller, Patrick, Smith, Terry K, Nadège Minois, Carmona-Gutierrez, Didac, Patrick Rockenfeller (596007), Didac Carmona-Gutierrez (374288), Minois, Nadège, Nadège Minois (596006), Smith, Terry K; id_orcid   +16 more
core   +1 more source

Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2. [PDF]

PLoS ONE, 2014
Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2.
Kyohei Higashi, Masataka Imamura, Satoshi Fudo, Takeshi Uemura, Ryotaro Saiki, Tyuji Hoshino, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi   +8 more
doaj   +1 more source

Spermidine Is an Intercellular Signal Modulating T3SS Expression in Pseudomonas aeruginosa

Microbiology Spectrum, 2022
Pseudomonas aeruginosa is a vital opportunistic human bacterial pathogen that causes acute and chronic infections. In this study, we set to determine whether the endogenous spermidine biosynthesis plays a role in regulation of type III secretion system ...
Qiqi Lin, Huishan Wang, Jiahui Huang, Zhiqing Liu, Qunyi Chen, Guohui Yu, Zeling Xu, Ping Cheng, Zhibin Liang, Lian-Hui Zhang   +9 more
doaj   +1 more source