Results 11 to 20 of about 92,235 (298)

Dietary spermidine improves cognitive function [PDF]

Cell Reports, 2021
Summary: Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood.
Sebastian J Hofer, Andreas Zimmermann, Raimund Pechlaner   +2 more
exaly   +8 more sources

Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice

Gut Microbes, 2020
Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important benefits in patients with aging-associated diseases and metabolic dysfunction ...
Yinhua Ni, Wenqing Tu, Zhengwei Fu
exaly   +3 more sources

Spermidine alleviating oxidative stress and apoptosis by inducing autophagy of granulosa cells in Sichuan white geese

Poultry Science, 2023
: Spermidine have been reported a role in antioxidative, antiaging, and antiinflammatory. Oxidative stress causes granulosa cell (GC) apoptosis, follicular atresia, and impairs poultry reproductive functions.
Dongmei Jiang, Xin Wang, Xuemin Zhou, Zelong Wang, Shuo Li, Qian Sun, Yilong Jiang, Chengweng Ji, Weikang Ling, Xiaoguang An, Bo Kang   +10 more
doaj   +2 more sources

Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis

Communications Biology, 2023
Kidney metabolism may be greatly altered in chronic kidney disease. Here we report that arginine metabolism is the most altered in unilateral ureteral obstruction (UUO)-induced fibrosis of the kidneys in metabolomic analysis.
Seishi Aihara, Kumiko Torisu, Yushi Uchida, Noriyuki Imazu, Toshiaki Nakano, Takanari Kitazono   +5 more
doaj   +2 more sources

Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms

Frontiers in Chemistry, 2023
Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties.
Parteek Prasher, Mousmee Sharma, Sachin Kumar Singh, Sachin Kumar Singh, Monica Gulati, Monica Gulati, Dinesh Kumar Chellappan, Rashi Rajput, Rashi Rajput, Gaurav Gupta, Gaurav Gupta, Alibek Ydyrys, Marzhan Kulbayeva, Ahmad Faizal Abdull Razis, Ahmad Faizal Abdull Razis, Babagana Modu, Babagana Modu, Javad Sharifi-Rad, Kamal Dua, Kamal Dua   +19 more
doaj   +2 more sources

Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster [PDF]

Frontiers in Neuroscience
IntroductionThe polyamines putrescine, spermidine, and spermine are ubiquitous metabolites synthesized in all cells. The intracellular levels of polyamines, especially spermidine, decrease in aging.
Florance Parweez, Florance Parweez, Roger Palou, Ruizhen Li, Lanna Kadhim, Heath MacMillan, Mike Tyers, Mike Tyers, X. Johné Liu, X. Johné Liu, X. Johné Liu   +10 more
doaj   +2 more sources

Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice

Scientific Reports, 2023
Aging is closely associated with the increased morbidity and mortality of ischemic cardiovascular disease, at least partially through impaired angiogenic capacity. Endothelial cells (ECs) play a crucial role in angiogenesis, and their angiogenic capacity
Daisuke Ueno, Koji Ikeda, Ekura Yamazaki, Akiko Katayama, Ryota Urata, Satoaki Matoba   +5 more
doaj   +2 more sources

Analysis of spermidine’s effect on coronary heart disease risk using bidirectional Mendelian randomization and LC-MS/MS [PDF]

Hereditas
Background This study examines the causal relationship between spermidine levels and coronary artery disease (CHD) risk using a bidirectional Mendelian Randomization (MR) approach.
Tianyi Wang, Li Lin, Yaodong Ding, Yang Zhang, Zehao Zhao, Ruixiang Feng, Yingxuan Bai, Zhennan Li, Yuncong Shi, Na Li, Yong Zeng   +10 more
doaj   +2 more sources

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

Journal of Neuroinflammation, 2022
Background Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD).
Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrino, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, Marina Jendrach   +18 more
doaj   +2 more sources

Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway

Molecular Medicine, 2022
Background Acute kidney injury (AKI) is still a critical problem in clinical practice, with a heavy burden for national health system around the world. It is notable that sepsis is the predominant cause of AKI for patients in the intensive care unit and ...
Xianzhi Li, Xiaojun Zhou, Xigao Liu, Xiaoyun Li, Xianzhou Jiang, Benkang Shi, Shuo Wang   +6 more
doaj   +2 more sources