Results 31 to 40 of about 46,168 (209)

Investigation into the Relationship between Spermidine Degradation and Phenolic Compounds Biosynthesis in Barley Seedlings under Ultraviolet B Stress

Plants, 2023
Barley germination under ultraviolet B (UV-B) illumination stress induces effective accumulation of phenolic compounds in the barley. Spermidine can enhance the biosynthesis of phenolic compounds and alleviate the oxidative damage caused by UV-B.
Chong Xie, Yahui Zhu, Chaoqun Leng, Qiaoe Wang, Pei Wang, Runqiang Yang   +5 more
doaj   +1 more source

Spermidine Promotes Cardioprotective Autophagy [PDF]

Circulation Research, 2017
Cardioprotection and lifespan extension by the natural polyamine spermidine Eisenberg et al Nat Med . 2016;22:1428–1438 A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life span and reverses aging-associated cardiac dysfunction in mice through induction of autophagy ...
Dan, Tong, Joseph A, Hill
openaire   +2 more sources

Exogenous Spermidine Promotes Germination of Aged Sorghum Seeds by Mediating Sugar Metabolism

Plants, 2022
Starch, a substance stored in seeds, is the main source of energy for germination in sorghum seeds. However, as the seeds age, the catabolism of seed starch is affected, thereby seriously damaging germination ability.
Min Zhang, Bang Li, Zuliang Wan, Xiaofei Chen, Chang Liu, Chunjuan Liu, Yufei Zhou   +6 more
doaj   +1 more source

Spermidine intake is associated with cortical thickness and hippocampal volume in older adults

NeuroImage, 2020
Background: The natural polyamine spermidine, known to be important for cellular function, decreases during aging. Previous research has demonstrated beneficial impact of spermidine intake on memory functions in both animal models and humans, suggesting ...
Claudia Schwarz, Nora Horn, Gloria Benson, Isabel Wrachtrup Calzado, Katharina Wurdack, Raimund Pechlaner, Ulrike Grittner, Miranka Wirth, Agnes Flöel   +8 more
doaj   +1 more source

Spermidine to the rescue for an aging heart [PDF]

Nature Medicine, 2016
A recent study shows that spermidine has beneficial effects on health and lifespan in mice, and that these effects are the result of improved cardiovascular function. Similar effects of spermidine on humans are supported by epidemiological studies.
Rafael de Cabo, Pácido Navas
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Spermidine-induced improvements in water relations and antioxidant defense enhance drought tolerance in yarrow (Achillea millefolium L.)

Heliyon
Drought stress poses a serious threat to agricultural productivity worldwide. This study investigated the mitigative effects of exogenous spermidine on drought stressed yarrow (Achillea millefolium L.). Plants were subjected to three drought levels (25 %,
Sajedeh Alijani, Mohammad-Reza Raji, Zohreh Emami Bistgani, Abdollah Ehtesham Nia, Mostafa Farajpour   +4 more
doaj   +1 more source

Spermidine Modify Antioxidant Activity in Cucumber Exposed to Salinity Stress

Agronomy, 2022
The effects of short-term 48 h long NaCl-stress and spermidine level modification on polyamines level and antioxidant status in cucumber (Cucumis sativus cv. Dar) leaves were investigated.
Agata Korbas, Jan Kubiś, Magdalena Rybus-Zając, Tamara Chadzinikolau   +3 more
doaj   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source