Results 31 to 40 of about 57,007 (201)

Spermidine-Regulated Biosynthesis of Heat-Stable Antifungal Factor (HSAF) in Lysobacter enzymogenes OH11

Frontiers in Microbiology, 2018
Heat-Stable Antifungal Factor (HSAF) and its analogs are antifungal natural products produced by the biocontrol agent Lysobacter enzymogenes. The production of HSAF is greatly influenced by environmental stimuli and nutrients, but the underlying ...
Yuan Chen, Yuan Chen, Lingjun Yu, Lingjun Yu, Fengquan Liu, Liangcheng Du   +5 more
doaj   +1 more source

Investigation into the Relationship between Spermidine Degradation and Phenolic Compounds Biosynthesis in Barley Seedlings under Ultraviolet B Stress

Plants, 2023
Barley germination under ultraviolet B (UV-B) illumination stress induces effective accumulation of phenolic compounds in the barley. Spermidine can enhance the biosynthesis of phenolic compounds and alleviate the oxidative damage caused by UV-B.
Chong Xie, Yahui Zhu, Chaoqun Leng, Qiaoe Wang, Pei Wang, Runqiang Yang   +5 more
doaj   +1 more source

Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N-8-citryl-spermidine and its N-1-(3,4-dihydroxybenzoyl) derivative

, 2008
The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophore petrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N-1-(3,4-dihydroxbenzoyl)-spermidine, with ...
Wilson, Keith S., Kadi, Nadia, Fogg, Mark J., Song, Lijiang, Oves-Costales, Daniel, Challis, Gregory L.   +5 more
core   +1 more source

Exogenous Spermidine Promotes Germination of Aged Sorghum Seeds by Mediating Sugar Metabolism

Plants, 2022
Starch, a substance stored in seeds, is the main source of energy for germination in sorghum seeds. However, as the seeds age, the catabolism of seed starch is affected, thereby seriously damaging germination ability.
Min Zhang, Bang Li, Zuliang Wan, Xiaofei Chen, Chang Liu, Chunjuan Liu, Yufei Zhou   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Spermidine intake is associated with cortical thickness and hippocampal volume in older adults

NeuroImage, 2020
Background: The natural polyamine spermidine, known to be important for cellular function, decreases during aging. Previous research has demonstrated beneficial impact of spermidine intake on memory functions in both animal models and humans, suggesting ...
Claudia Schwarz, Nora Horn, Gloria Benson, Isabel Wrachtrup Calzado, Katharina Wurdack, Raimund Pechlaner, Ulrike Grittner, Miranka Wirth, Agnes Flöel   +8 more
doaj   +1 more source

Research Progress and Potential Applications of Spermidine in Ocular Diseases

Pharmaceutics, 2022
Spermidine, a natural polyamine, exists in almost all human tissues, exhibiting broad properties like anti-aging, autophagy induction, anti-inflammation, anti-oxidation, cell proliferation activation, and ion channel regulation.
Wentao Han, Haoyu Li, Baihua Chen
doaj   +1 more source

Spermidine Oxidation-Mediated Degeneration of Retinal Pigment Epithelium in Rats [PDF]

, 2017
Retinal pigment epithelium (RPE) degeneration is a crucial event in dry age-related macular degeneration and gyrate atrophy. The polyamine spermidine has been shown to induce RPE cell death in vitro.
Masatsugu Nakamura, Yukie Fujita-Koyama, Osamu Katsuta, Katsuhiko Shinomiya, Koji Ohashi, Masaaki Kageyama, Shin-ichiro Hirai   +6 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Spermidine-induced improvements in water relations and antioxidant defense enhance drought tolerance in yarrow (Achillea millefolium L.)

Heliyon
Drought stress poses a serious threat to agricultural productivity worldwide. This study investigated the mitigative effects of exogenous spermidine on drought stressed yarrow (Achillea millefolium L.). Plants were subjected to three drought levels (25 %,
Sajedeh Alijani, Mohammad-Reza Raji, Zohreh Emami Bistgani, Abdollah Ehtesham Nia, Mostafa Farajpour   +4 more
doaj   +1 more source