Results 31 to 40 of about 92,235 (298)

High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study

Nutrients, 2023
(1) Background: Spermidine is a biogenic polyamine that plays a crucial role in mammalian metabolism. As spermidine levels decline with age, spermidine supplementation is suggested to prevent or delay age-related diseases.
S. Senekowitsch, Eliza Wietkamp, M. Grimm, F. Schmelter, P. Schick, Anna Kordowski, C. Sina, Hans Otzen, W. Weitschies, M. Smollich   +9 more
semanticscholar   +1 more source

Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study

Frontiers in Nutrition, 2022
The relationship between serum spermidine levels and future cardiovascular disease risk has not yet been well elucidated in the general population based on community studies.
Liqiang Zheng, Liqiang Zheng, Liqiang Zheng, Yanxia Xie, Zhaoqing Sun, Rui Zhang, Yanan Ma, Yanan Ma, Jiahui Xu, Jiahui Xu, Jia Zheng, Jia Zheng, Qianyi Xu, Qianyi Xu, Zhao Li, Xiaofan Guo, Guozhe Sun, Fuguo Xing, Yingxian Sun, Deliang Wen   +19 more
doaj   +1 more source

Extension of Yeast Chronological Lifespan by Methylamine [PDF]

, 2012
Background: Chronological aging of yeast cells is commonly used as a model for aging of human post-mitotic cells. The yeast Saccharomyces cerevisiae grown on glucose in the presence of ammonium sulphate is mainly used in yeast aging research.
A Mesquita, AE Roux, AL Alvers, AR Hipkiss, BK Kennedy, BK Kennedy, CR Burtner, D Longo Valter, E Morselli, EJ Masoro, GJ Sulter, HR Waterham, Ida J. van der Klei, J Roosen, J Santos, JA Komduur, JDL Smith, JP van Dijken, JP Van Dijken, K Zwart, L Pollegioni, LP Dijken, M Kaeberlein, M MacLean, Marten Veenhuis, P Fabrizio, P Ludovico, P Wardman, R Saraya, Sanjeev Kumar, Sophie D. Lefevre, T Eisenberg, Valdur Saks, Y Pan   +33 more
core   +5 more sources

Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus

Open Life Sciences, 2021
Spermidine is important for the hypothalamic control of pituitary secretion of hormones involved in neuroendocrine functions in mammals. In this study, the effect of exogenous spermidine on the expression of genes and proteins related to polyamine ...
Jiang Dongmei, Mo Guilin, Jiang Yilong, Kang Bo   +3 more
doaj   +1 more source

Spermidine Promotes Cardioprotective Autophagy [PDF]

Circulation Research, 2017
A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life span and reverses aging-associated cardiac dysfunction in mice through induction of autophagy. Similar protective effects of spermidine on human cardiovascular health were also suggested by epidemiological studies.
Dan, Tong, Joseph A, Hill
openaire   +2 more sources

Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2. [PDF]

PLoS ONE, 2014
Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2.
Kyohei Higashi, Masataka Imamura, Satoshi Fudo, Takeshi Uemura, Ryotaro Saiki, Tyuji Hoshino, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi   +8 more
doaj   +1 more source

Spermidine Is an Intercellular Signal Modulating T3SS Expression in Pseudomonas aeruginosa

Microbiology Spectrum, 2022
Pseudomonas aeruginosa is a vital opportunistic human bacterial pathogen that causes acute and chronic infections. In this study, we set to determine whether the endogenous spermidine biosynthesis plays a role in regulation of type III secretion system ...
Qiqi Lin, Huishan Wang, Jiahui Huang, Zhiqing Liu, Qunyi Chen, Guohui Yu, Zeling Xu, Ping Cheng, Zhibin Liang, Lian-Hui Zhang   +9 more
doaj   +1 more source

Decreased sensitivity to aspirin is associated with altered polyamine metabolism in human prostate cancer cells [PDF]

, 2015
Acknowledgments We thank NHS Grampian for financial support of this work.Peer reviewedPublisher ...
Cameron, Gary A., Li, Jun, Wallace, Heather M.   +2 more
core   +1 more source

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline

JAMA Network Open, 2022
Key Points Question Does 12-month spermidine supplementation have a beneficial impact on memory performance, as well as on other neuropsychological, behavioral, and physiological parameters, in older individuals with subjective cognitive decline when ...
C. Schwarz, Gloria S. Benson, N. Horn, Katharina Wurdack, U. Grittner, Ralph Schilling, Stefanie Märschenz, T. Köbe, Sebastian J. Hofer, C. Magnes, Slaven Stekovic, T. Eisenberg, S. Sigrist, Dietmar Schmitz, M. Wirth, F. Madeo, A. Flöel   +16 more
semanticscholar   +1 more source

Alleviation of low-irrigation effects on chickpea (Cicer arietinum L.) using spermidine [PDF]

پژوهش‌های حبوبات ایران, 2020
IntroductionChickpea is one of the pulse crops and its protein percent is about 22 to 24 percent. Therefore it plays an important nutritional role in human being diet.
Vahid Sharifi, Manouchehr Gholipoor, Hamid Abbasdokht   +2 more
doaj   +1 more source