Results 51 to 60 of about 57,007 (201)

Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats

, 2020
Let alone calorie restriction, life span extension in higher organisms has proven to be difficult to achieve using simple drugs. Previous studies have shown that the polyamine spermidine increased the maximum life span in C.
Popa-Wagner, A, Filfan, M, Olaru, A, Margaritescu, C, Udristoiu, I, Petcu, E, Hermann, DM   +6 more
core   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

Molecular targets of spermidine: implications for cancer suppression

Cell Stress, 2023
Spermidine is a ubiquitous, natural polyamine with geroprotective features. Supplementation of spermi-dine extends the lifespan of yeast, worms, flies, and mice, and dietary spermidine intake correlates with reduced human mortality.
Andreas Zimmermann, Sebastian J. Hofer, Frank Madeo   +2 more
doaj   +1 more source

Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway

Molecular Medicine, 2022
Background Acute kidney injury (AKI) is still a critical problem in clinical practice, with a heavy burden for national health system around the world. It is notable that sepsis is the predominant cause of AKI for patients in the intensive care unit and ...
Xianzhi Li, Xiaojun Zhou, Xigao Liu, Xiaoyun Li, Xianzhou Jiang, Benkang Shi, Shuo Wang   +6 more
doaj   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish

Biology Open, 2016
Polyamines are small poly-cations essential for all cellular life. The main polyamines present in metazoans are putrescine, spermidine and spermine.
Hans Georg Frohnhöfer, Silke Geiger-Rudolph, Martin Pattky, Martin Meixner, Carolin Huhn, Hans-Martin Maischein, Robert Geisler, Ines Gehring, Florian Maderspacher, Christiane Nüsslein-Volhard, Uwe Irion   +10 more
doaj   +1 more source

Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice

Scientific Reports, 2023
Aging is closely associated with the increased morbidity and mortality of ischemic cardiovascular disease, at least partially through impaired angiogenic capacity. Endothelial cells (ECs) play a crucial role in angiogenesis, and their angiogenic capacity
Daisuke Ueno, Koji Ikeda, Ekura Yamazaki, Akiko Katayama, Ryota Urata, Satoaki Matoba   +5 more
doaj   +1 more source

Spermidine N-D5

, 2002
Inelastic Neutron Scattering spectrum of Spermidine N-D5, D₂N(CH₂)₃ND(CH₂)₃ND₂, measured on the TOSCA ...
M. P. M. Marques, Universidade de Coimbra, Portugal
core   +1 more source

An Engineered Supramolecular Pathway for Enhanced Electrochemiluminescence

Advanced Science, EarlyView.
A supramolecular electrochemiluminescent (ECL) system is presented in which cucurbit[7]uril (CB7) is covalently linked to [Ru(bpy)3]2+, forming a recognition‐responsive emitter. Host‒guest preorganization of tri‐n‐propylamine enables intramolecular ECL, boosting intensity by 162% compared to the standard system.
Maria Vittoria Balli, Madhurima Jana, Chiara Capolungo, Patrick Gruhs, Pierre Picchetti, Giovanni Valenti, Frank Biedermann, Luca Prodi   +7 more
wiley   +1 more source