Results 51 to 60 of about 56,045 (256)

Non-linear associations of serum spermidine with type 2 diabetes mellitus and fasting plasma glucose: a cross-sectional study

Frontiers in Nutrition
BackgroundPrevious animal experiments have demonstrated the potential of spermidine to mitigate glucose intolerance, insulin resistance, and hyperinsulinemia.
Xiaohong Zhang, Xiaohong Zhang, Xiaohong Zhang, Yao Zhang, Shaojie Li, Min Liu, Ying Lu, Mengyao He, Zhaoqing Sun, Mingfeng Ma, Liqiang Zheng, Liqiang Zheng, Liqiang Zheng, Liqiang Zheng   +13 more
doaj   +1 more source

Effect of exogenous spermidine on expression profile of reproductive hormone receptors in mouse ovaries

浙江大学学报. 农业与生命科学版, 2017
The polyamines spermidine and spermine and their precursor putrescine are a class of compounds containing two or more amino groups and participate in the regulation of various physiological and pathological processes by interacting with negatively ...
LONG Shiyun, JIANG Dongmei, CHEN Ziyu, GUAN Cheng, YI Zhixin, KANG Bo   +5 more
doaj   +1 more source

Spermidine Suppresses Development of Experimental Abdominal Aortic Aneurysms

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The protective effects of polyamines on cardiovascular disease have been demonstrated in many studies. However, the roles of spermidine, a natural polyamine, in abdominal aortic aneurysm (AAA) disease have not been studied.
Shuai Liu, Tingting Huang, Rui Liu, Huoying Cai, Baihong Pan, Mingmei Liao, Pu Yang, Lei Wang, Jianhua Huang, Yingbin Ge, Baohui Xu, Wei Wang   +11 more
doaj   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Effect of Spermidine on Actomyosin System. [PDF]

, 1969
The inhibitory action of spermidine aliphatic polyamine, on myosin B was studied in relation to the ionic strength. On the basis of this result, it was concluded that the inhibitory action of spermidine on the actomyosin system is not due to the increase
Sounosuke, Takahashi, Tetsuzo, Yamamoto
core   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging [PDF]

, 2021
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. The polyamine pathway is highly conserved from bacteria to mammals and spermidine (prominently found in some kinds of aged cheese ...
Madeo, Frank, Eisenberg, Tobias, Sigrist, Stephan, J, Liang, YongTian, Hofer, Sebastian J., Zimmermann, Andreas, Hofer, Sebastian,, Dengjel, Jörn, Sigrist, Stephan,, Hofer, Sebastian, J, Sigrist, Stephan J., Schroeder, Sabrina, Kroemer, Guido   +12 more
core   +1 more source

Mitigation of salinity stress in yarrow (Achillea millefolium L.) plants through spermidine application.

PLoS ONE
This study investigated the mitigating effects of spermidine on salinity-stressed yarrow plants (Achillea millefolium L.), an economically important medicinal crop.
Sajedeh Alijani, Mohammad-Reza Raji, Zohreh Emami Bistgani, Abdollah Ehtesham Nia, Mostafa Farajpour   +4 more
doaj   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Spermidine Promotes Cardioprotective Autophagy [PDF]

Circulation Research, 2017
Cardioprotection and lifespan extension by the natural polyamine spermidine Eisenberg et al Nat Med . 2016;22:1428–1438 A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life span and reverses aging-associated cardiac dysfunction in mice through induction of autophagy ...
Dan, Tong, Joseph A, Hill
openaire   +2 more sources