Results 71 to 80 of about 52,673 (252)

Natural Variations in the Activity of Hydroxycinnamoyl Transferases Promote Accumulation of Metabolites Conferring Rice Resistance. [PDF]

Plant Biotechnol J
ABSTRACT Plant‐derived secondary metabolites act as regulators of in planta defence. Plant phenylpropanoid metabolic compounds, including final metabolites such as lignin and flavonoids, and a few intermediate metabolites play critical roles in defence.
Chen D, Liu J, Yuan G, Liu Y, Zhu W, Chen Y, Geng J, Fan J, Dong X, Yuan M.   +9 more
europepmc   +2 more sources

Nickel Foam Electrodes—A Versatile, Powerful, and Readily Available Tool in Electro‐Organic Synthesis

The Chemical Record, EarlyView.
Nickel foam—one material, two faces, and several versatile roles depending on electrolytic conditions. For more than 50 years, nickel foam electrodes have served in electrosynthesis as powerful and readily available electrode materials. Due to their inexpensive nature and easy handling, they have been widely employed.
Rok Narobe, Johannes Schneider, Siegfried R. Waldvogel   +2 more
wiley   +1 more source

Modeling of spermidine binding to hOCT2.

, 2014
(A) Amino acid residues involved in transport activity of the three amines (red) and of putrescine and spermidine (blue) are shown on α-helices 1 to 12, whose relative positions were constructed based on the structure model of hOCT2 [31]. (B) View of the
Ryotaro Saiki (597499), Masataka Imamura (597496), Satoshi Fudo (597497), Kazuei Igarashi (597503), Toshihiko Toida (597501), Keiko Kashiwagi (597502), Takeshi Uemura (597498), Tyuji Hoshino (597500), Kyohei Higashi (597495)   +8 more
core   +1 more source

Spermidine dietary supplementation and polyamines level in reference to survival and lifespan of honey bees

Scientific Reports, 2023
Honey bee health has been an important and ongoing topic in recent years. Honey bee is also an important model organism for aging studies. Polyamines, putrescine, spermidine and spermine, are ubiquitous polycations, involved in a wide range of cellular ...
Srđana Đorđievski, Elvira L. Vukašinović, Tatjana V. Čelić, Ivan Pihler, Marko Kebert, Danijela Kojić, Jelena Purać   +6 more
doaj   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Spermidine Prevents Ethanol and Lipopolysaccharide-Induced Hepatic Injury in Mice

, 2021
To date, there is no effective treatment for alcoholic liver disease, despite its prevalence world-wide. Because alcohol consumption is associated with oxidative stress-induced liver injury and pro-inflammatory responses, naturally occurring antioxidants
Pamela L. Tuma, Karina Reyes-Gordillo, Jaime Arellanes-Robledo, Ruchi Shah, Ying Cheng, Joseph Ibrahim, Raghabendra Adhikari   +6 more
core   +1 more source

Analysis of spermidine’s effect on coronary heart disease risk using bidirectional Mendelian randomization and LC-MS/MS

Hereditas
Background This study examines the causal relationship between spermidine levels and coronary artery disease (CHD) risk using a bidirectional Mendelian Randomization (MR) approach.
Tianyi Wang, Li Lin, Yaodong Ding, Yang Zhang, Zehao Zhao, Ruixiang Feng, Yingxuan Bai, Zhennan Li, Yuncong Shi, Na Li, Yong Zeng   +10 more
doaj   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Spermidine in dementia [PDF]

Wiener klinische Wochenschrift, 2019
SummaryPrevious studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. This manuscript focuses on the correlation of serum spermidine levels between age and between performance in mini-mental state examinations.
Thomas Pekar, Aribert Wendzel, Walter Flak, Alexandra Kremer, Susanne Pauschenwein-Frantsich, Anna Gschaider, Felix Wantke, Reinhart Jarisch   +7 more
openaire   +2 more sources

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source