Results 71 to 80 of about 57,007 (201)

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Effect of spermidine intake on overload‐induced skeletal muscle hypertrophy in male mice

Physiological Reports
Skeletal muscles exhibit high plasticity, such as overload‐induced hypertrophy or immobilization‐induced atrophy. During sports, skeletal muscle hypertrophy is induced by training to improve performance.
Tomohiro Iwata, Takanaga Shirai, Riku Tanimura, Ryoto Iwai, Tohru Takemasa   +4 more
doaj   +1 more source

Spermidine Prevents Ethanol and Lipopolysaccharide-Induced Hepatic Injury in Mice

, 2021
To date, there is no effective treatment for alcoholic liver disease, despite its prevalence world-wide. Because alcohol consumption is associated with oxidative stress-induced liver injury and pro-inflammatory responses, naturally occurring antioxidants
Pamela L. Tuma, Karina Reyes-Gordillo, Jaime Arellanes-Robledo, Ruchi Shah, Ying Cheng, Joseph Ibrahim, Raghabendra Adhikari   +6 more
core   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Rational engineering of homospermidine synthase for enhanced catalytic efficiency toward spermidine synthesis

Synthetic and Systems Biotechnology
Spermidine is a naturally occurring polyamine widely utilized in the prevention and treatment of various diseases. Current spermidine biosynthetic methods have problems such as low efficiency and complex multi-enzyme catalysis.
Wenjing Liu, Xiaoxiang Hu, Yi Yan, Yujie Cai   +3 more
doaj   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Spermidine in health and disease

, 2018
Having your longevity and eating too Although caloric restriction has clear benefits for maximizing health span and life span, it is sufficiently unpleasant that few humans stick to it. Madeo et al.
Federico Pietrocola, Frank Madeo, Tobias Eisenberg, Guido Kroemer   +3 more
core   +1 more source

Effects of Spermidine on Mouse Gut Morphology, Metabolites, and Microbial Diversity

, 2023
Spermidine is a class of biologically active organic small molecules that play an important role in maintaining intestinal homeostasis. The specific objective of this study was to explore the effects of spermidine on intestinal morphology, metabolites ...
Qian Sun, Ze-Long Wang, Bo Kang, Xiao-Hui Si, Chun-Yang Niu, De-Bing Li, Jia-Di Yang, Xin Wang, Xiao-Guang An, Cheng-Weng Ji, Dong-Mei Jiang, Wei-Kang Ling, Yong-Ni Guo, Lin Bai, Sun, Qian, Wang, Xin, Ling, Wei-Kang, Li, De-Bing, Si, Xiao-Hui, Wang, Ze-Long, Bai, Lin, An, Xiao-Guang, Ji, Cheng-Weng, Yang, Jia-Di, Niu, Chun-Yang, Guo, Yong-Ni, Kang, Bo, Jiang, Dong-Mei   +27 more
core   +1 more source

Biosensors for Food Safety and Adulteration Monitoring: Applications, Smart Packaging Integration, and Pathways to Intelligent, Field‐Deployable Detection Systems

Food Safety and Health, EarlyView.
Biosensors enable rapid, sensitive, and portable detection of pathogens, contaminants, allergens, and food adulteration. Integration with smart packaging, smartphones, IoT, and machine learning supports real‐time monitoring and intelligent decision‐making, whereas microfluidics, biodegradable materials, explainable AI, and blockchain offer pathways ...
Mohima Akther Any, Abid Hassan Arnab, Liza Akter, Yusuf Chowdhury, Md. Hassan Bin Nabi, Md Abu Rayhan, Nazmul Islam, Wahidu Zzaman   +7 more
wiley   +1 more source

Podocyte healthy self-eating boosted by a spermidine meal?

, 2020
International audienceThe mechanisms sustaining a high level of autophagy in podocytes are not well delineated. Seminal studies had unraveled that the polyamine pathway is involved in the regulation of aging and autophagy.
Lenoir, Olivia, Tharaux, Pierre-Louis, Olivia Lenoir, Pierre-Louis Tharaux   +3 more
core   +1 more source