Results 71 to 80 of about 92,235 (298)

Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine [PDF]

Biochemical Journal, 1987
Polyamine biosynthesis in intact cells can be exquisitely controlled with exogenous polyamines through the regulation of rate-limiting biosynthetic enzymes, particularly ornithine decarboxylase (ODC). In an attempt to exploit this phenomenon as an antiproliferative strategy, certain polyamine analogues have been identified [Porter, Cavanaugh, Stolowich,
C W, Porter, F G, Berger, A E, Pegg, B, Ganis, R J, Bergeron   +4 more
openaire   +2 more sources

Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells. [PDF]

, 1983
Treatment of mouse lymphoma S49 cells with D,L-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, depleted cellular polyamine levels and stopped cell growth. The cells were arrested predominantly in G1.
Coffino, P, Marton, LJ, McConlogue, LC
core  

Glutamate, Ornithine, Arginine, Proline, and Polyamine Metabolic Interactions: The Pathway Is Regulated at the Post-Transcriptional Level [PDF]

, 2016
The metabolism of glutamate into ornithine, arginine, proline, and polyamines is a major network of nitrogen-metabolizing pathways in plants, which also produces intermediates like nitric oxide, and γ-aminobutyric acid (GABA) that play critical roles in ...
Boubker eBarchi, Maegan eGagne, Rajtilak eMajumdar, Rakesh eMinocha, Stephanie eLong, Subhash C Minocha, Swathi eTurlapati, Swathi eTurlapati   +7 more
core   +4 more sources

Spermidine in the Bacterial Cell [PDF]

Journal of General Microbiology, 1961
SUMMARY The concentration of spermidine in extracts of various micro-organisms was determined; Neurospora crassa contained the highest concentrations of spermidine, while in Pseudomonas aeruginosa, Escherichia coli and Saccharomyces cerevisiae the concentration of spermidine was lower.
U, BACHRACH, I, COHEN
openaire   +2 more sources

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Spermidine intake is associated with cortical thickness and hippocampal volume in older adults

NeuroImage, 2020
Background: The natural polyamine spermidine, known to be important for cellular function, decreases during aging. Previous research has demonstrated beneficial impact of spermidine intake on memory functions in both animal models and humans, suggesting ...
Claudia Schwarz, Nora Horn, Gloria Benson, Isabel Wrachtrup Calzado, Katharina Wurdack, Raimund Pechlaner, Ulrike Grittner, Miranka Wirth, Agnes Flöel   +8 more
doaj   +1 more source

Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1α upregulation and autophagy.

Free Radical Biology & Medicine, 2020
Distinct metabolic programs, either energy-consuming anabolism or energy-generating catabolism, were required for different biological functions. Macrophages can adopt different immune phenotypes in response to various cues and exhibit anti- or pro ...
Rui Liu, Xiaolei Li, Hui Ma, Qian Yang, Qianwen Shang, Lin Song, Zhiyuan Zheng, Shengchao Zhang, Yongsha Pan, Peiqing Huang, Jiankai Fang, Yanan Li, Zhanhong Liu, Lijuan Cao, Chao Feng, Zheng Gong, Yongjing Chen, Ying Wang, G. Melino, C. Shao, Yufang Shi   +20 more
semanticscholar   +1 more source

Spermidine Modify Antioxidant Activity in Cucumber Exposed to Salinity Stress

Agronomy, 2022
The effects of short-term 48 h long NaCl-stress and spermidine level modification on polyamines level and antioxidant status in cucumber (Cucumis sativus cv. Dar) leaves were investigated.
Agata Korbas, Jan Kubiś, Magdalena Rybus-Zając, Tamara Chadzinikolau   +3 more
doaj   +1 more source

The Development of Polyamines throughout Brassica rapa over its Lifecycle [PDF]

, 2014
Polyamines are naturally produced chemicals in plants involved in growth, development and stress response. The primary objective of my study is to create a profile of changes in the entire life of the plant, in every organ at all stages of development ...
Larsen, Jon, Minocha, Subhash C, Sullivan, Matthew Ryan   +2 more
core   +1 more source

Spermidine cures yeast of prions [PDF]

Microbial Cell, 2016
Prions are self-perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals. The molecular basis underlying their conversion from a normally soluble protein into the prion form remains largely unknown. Studies aimed at uncovering these mechanism(s) are therefore essential if we are to develop effective ...
Shaun H. Speldewinde, Chris M. Grant
openaire   +3 more sources