Results 81 to 90 of about 46,168 (209)

Quantitative Spermidine Detection in Cosmetics using an Organic Transistor‐Based Chemical Sensor

ChemistryOpen
Spermidine is an essential biomarker related to antiaging. Although the detection of spermidine levels is in high demand in life science fields, easy‐to‐use analytical tools without sample purification have not yet been fully established.
Dr. Yui Sasaki, Kohei Ohshiro, Miyuki Kato, Hikaru Tanaka, Akari Yamagami, Dr. Kazutake Hagiya, Prof. Dr. Tsuyoshi Minami   +6 more
doaj   +1 more source

Contribution of One‐Electron Oxidation of Purine and Pyrimidine Bases to the Photo‐ and Radiation‐Induced Damage to Cellular DNA

ChemPhysChem, Volume 27, Issue 15, 14 August 2026.
One‐electron oxidation of purine and pyrimidine bases of isolated and cellular DNA generates related reactive base radical cations that are converted into final decomposition products through deprotonation and hydration. In the case of guanine, the most susceptible nucleobase to one‐electron oxidants, 8‐hydroxy‐7,8‐dihydroguanyl radical, thus formed by
Jean Cadet, Dimitar Angelov, Paolo DI Mascio, J. Richard Wagner   +3 more
wiley   +1 more source

Microbiota–Neuroinflammation Crosstalk in Primary Brain Tumors: Focus on Glioblastoma

Brain and Behavior, Volume 16, Issue 8, August 2026.
Microbiota–neuroinflammation crosstalk in GBM. The schematic summarizes how gut microbiota and microbiota‐derived signals may influence GBM biology through gut–brain signaling, microbial metabolites, systemic immune modulation, BBB‐related pathways, tumor‐associated microbial signals, and immune‐metabolic changes within the GBM microenvironment.
Tareq Nayef AlRamadneh, Renuka Jyothi S, Priya Priyadarshini Nayak, Anima Nanda, Shaker Al Hasnaawei, Akanksha Bhatt, Ashish Singh Chauhan, Siya Singla, Mehrdad Nourizadeh   +8 more
wiley   +1 more source

Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300

Experimental and Molecular Medicine, 2018
Aging: toward a natural treatment for osteoarthritis The naturally occurring small molecule spermidine might prevent and repair the cartilage damage in osteoarthritis, commonly associated with aging.
Pradeep K. Sacitharan, Seint Lwin, George Bou Gharios, James R. Edwards   +3 more
doaj   +1 more source

Effects of ketogenic and low‐carbohydrate diet on glucose and weight control in type 2 diabetes mellitus patients along with metabolome change

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Both the low‐carbohydrate diet (LCD) and the ketogenic diet (KD) positively affect body weight and glucose metabolism in type 2 diabetes. Metabolomic signatures sensitively reflect each diet and correlate with clinical improvements – distinct metabolite associations with glycated haemoglobin and weight were identified for LCD versus KD.
Yao Wang, Haozhe He, Zhenjing Lyu, Yeyang Wang, Li Chen, Junbin Liang, Cong Lin, Huanhuan Wang, Shiping Zhang, Gugen Xu, Junzhang Tian, Kejing Zeng   +11 more
wiley   +1 more source

Impact of Lactic Acid and Fermented Dairy‐Based Marinades on Quality Attributes and Biogenic Amine Formation in Turkey Breast Meat

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Turkey breast meat was marinated with lactic acid (pH 4.0), yogurt whey, kefir, or yogurt (1:1, w/w) for 24 h at 4°C and then cooked at 185°C for 15 min. Fermented dairy‐based marinades improved meat quality without promoting excessive biogenic amine formation.
Gülsüme Biçakci, Ercan Sarica
wiley   +1 more source

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

Oral Spermidine Supplementation Preserves Submandibular Gland Function After Radiotherapy: Mechanistic Insights and Use in a Phase II Randomized Clinical Trial

MedComm, Volume 7, Issue 8, August 2026.
Radiotherapy‐induced xerostomia severely impairs quality of life. Integrated multiomics, organoids, murine models, and a randomized Phase II trial identified spermidine as a key radiation‐responsive metabolite. Oral spermidine preserved salivary gland function, maintained acinar cell integrity through Golgi‐mediated posttranslational modifications ...
Yu Min, Kun Gao, Yingtong Liu, Lei Dai, Xingchen Peng   +4 more
wiley   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang, Xin Fu, Jingchao Bai, Yanguo Liu, Kai Huang   +4 more
wiley   +1 more source