Results 81 to 90 of about 92,235 (298)

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Spermidine-induced improvements in water relations and antioxidant defense enhance drought tolerance in yarrow (Achillea millefolium L.)

Heliyon
Drought stress poses a serious threat to agricultural productivity worldwide. This study investigated the mitigative effects of exogenous spermidine on drought stressed yarrow (Achillea millefolium L.). Plants were subjected to three drought levels (25 %,
Sajedeh Alijani, Mohammad-Reza Raji, Zohreh Emami Bistgani, Abdollah Ehtesham Nia, Mostafa Farajpour   +4 more
doaj   +1 more source

Research Progress and Potential Applications of Spermidine in Ocular Diseases

Pharmaceutics, 2022
Spermidine, a natural polyamine, exists in almost all human tissues, exhibiting broad properties like anti-aging, autophagy induction, anti-inflammation, anti-oxidation, cell proliferation activation, and ion channel regulation.
Wentao Han, Haoyu Li, Baihua Chen
doaj   +1 more source

Non-monotonic swelling of a macroion due to correlation-induced charge inversion [PDF]

, 2008
It is known that a large, charged body immersed in a solution of multivalent counterions may undergo charge inversion as the counterions adsorb to its surface.
Arenzon, B.I. Shklovskii, Bloomfield, Brian Skinner, Ennis, Fennell Evans, Gosule, Gronbech-Jensen, Grosberg, Kjellander, Kjellander, Konradi, Moreira, Moreira, Nguyen, Raspaud, Rouzina, Shklovskii, Shklovskii, Solis, Verwey, Zhang   +21 more
core   +1 more source

Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics

bioRxiv, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health and the world economy, especially because no approved specific drugs or vaccines are available.
N. Gassen, Jan Papies, T. Bajaj, Frederik Dethloff, J. Emanuel, Katja Weckmann, Daniela Heinz, Nicolas Heinemann, M. Lennarz, A. Richter, Daniela Niemeyer, V. Corman, Patrick Giavalisco, C. Drosten, M. Müller   +14 more
semanticscholar   +1 more source

Genome‐Wide Association Study Reveals Insect Genetics and Microbial Symbiont Effects on Susceptibility of Diaphorina citri to the Citrus Greening Pathogen, Candidatus Liberibacter Asiaticus

Advanced Science, EarlyView.
This study investigates the genetic and microbial factors influencing the susceptibility of Diaphorina citri to the citrus greening pathogen Candidatus Liberibacter asiaticus (CLas), employing a microbiome Genome Wide Association Study. The research identifies a key gene encoding an MFS‐type transporter contributing to CLas infectivity and abundance in
Kai Liu, Qingcui He, Zeyue Lin, Shixuan Huang, Zichun Zhong, Pingyang Zhu, Mengge Gao, Luyao Zhao, Han Jin, Guiting Wu, Gurr M. Geoff, Qunxin Han, Rui Pang   +12 more
wiley   +1 more source

Effect of exogenous spermidine on expression profile of reproductive hormone receptors in mouse ovaries

浙江大学学报. 农业与生命科学版, 2017
The polyamines spermidine and spermine and their precursor putrescine are a class of compounds containing two or more amino groups and participate in the regulation of various physiological and pathological processes by interacting with negatively ...
LONG Shiyun, JIANG Dongmei, CHEN Ziyu, GUAN Cheng, YI Zhixin, KANG Bo   +5 more
doaj   +1 more source

Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial [PDF]

, 2019
Background: Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues.
Benson, Gloria, Buchert, Ralph, Flöel, Agnes, Grittner, Ulrike, Hetzer, Stefan, Horn, Nora, Kopp, Ute, Köbe, Theresa, Lange, Catharina, Madeo, Frank, Maglione, Marta, Mai, Knut, Michael, Eva, Märschenz, Stefanie, Schmitz, Dietmar, Schwarz, Claudia, Sigrist, Stephan J., Stekovic, Slaven, Wirth, Miranka   +18 more
core   +2 more sources

Spermidine and spermine exert protective effects within the lung

Pharmacology Research & Perspectives, 2021
Asthma is a heterologous disease that is influenced by complex interactions between multiple environmental exposures, metabolism, and host immunoregulatory processes. Specific metabolites are increasingly recognized to influence respiratory inflammation.
M. Wawrzyniak, D. Groeger, R. Frei, Ruth Ferstl, P. Wawrzyniak, Krzysztof Krawczyk, B. Pugin, Weronika Barcik, Patrick Westermann, A. Dreher, M. Scharl, M. Jutel, C. Akdis, L. O' Mahony   +13 more
semanticscholar   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source