Results 61 to 70 of about 52,673 (252)

Monitoring and Mitigation Strategies for Hazardous Compounds in Chinese Rice Wine (Huangjiu): A Comprehensive Review

Food Safety and Health, EarlyView.
This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu, Zhiqiang Kong, Lin Li, Yifan Zhang, Bei Fan, Minmin Li   +5 more
wiley   +1 more source

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source

Spermidine induced aggregation of terphenyl derivative: An efficient probe for detection of spermidine in living cells

, 2018
A terphenyl derivative 3 has been designed and synthesized which undergoes self-assembly in mixed aqueous media to form weakly emissive aggregates.
Manoj Kumar, Tejpal, Ruchi, Ruchi Tejpal, Bhalla, Vandana, Vandana Bhalla, Kumar, Manoj   +5 more
core   +1 more source

Dietary spermidine for lowering high blood pressure

, 2017
Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease.
Kiechl, Stefan, Madeo, Frank, Dammbrueck, Christopher, Magnes, Christoph, Ruckenstuhl, Christoph, Sedej, Simon, Gross, Angelina S., Herbst, Viktoria, Mühlfeld, Christian, Eisenberg, Tobias, Stekovic, Slaven, Linke, Wolfgang A., Zimmermann, Andreas, Dengjel, Jörn, Linke, Wolfgang A, Carmona-Gutierrez, Didac, Pieber, Thomas R., Sigrist, Stephan J., Schroeder, Sabrina, Pietrocola, Federico, Kroemer, Guido, Dengjel, Joern, Schmidt, Albrecht, Abdellatif, Mahmoud, Sadoshima, Junichi, Pendl, Tobias, Harger, Alexandra, Gross, Angelina S, Pieber, Thomas R, Sigrist, Stephan J, Schipke, Julia   +30 more
core   +2 more sources

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N-8-citryl-spermidine and its N-1-(3,4-dihydroxybenzoyl) derivative

, 2008
The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophore petrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N-1-(3,4-dihydroxbenzoyl)-spermidine, with ...
Wilson, Keith S., Kadi, Nadia, Fogg, Mark J., Song, Lijiang, Oves-Costales, Daniel, Challis, Gregory L.   +5 more
core   +1 more source

Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish

Biology Open, 2016
Polyamines are small poly-cations essential for all cellular life. The main polyamines present in metazoans are putrescine, spermidine and spermine.
Hans Georg Frohnhöfer, Silke Geiger-Rudolph, Martin Pattky, Martin Meixner, Carolin Huhn, Hans-Martin Maischein, Robert Geisler, Ines Gehring, Florian Maderspacher, Christiane Nüsslein-Volhard, Uwe Irion   +10 more
doaj   +1 more source

Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway

Molecular Medicine, 2022
Background Acute kidney injury (AKI) is still a critical problem in clinical practice, with a heavy burden for national health system around the world. It is notable that sepsis is the predominant cause of AKI for patients in the intensive care unit and ...
Xianzhi Li, Xiaojun Zhou, Xigao Liu, Xiaoyun Li, Xianzhou Jiang, Benkang Shi, Shuo Wang   +6 more
doaj   +1 more source

A spermidine riboswitch class in bacteria exploits a close variant of an aptamer for the enzyme cofactor S-adenosylmethionine

Cell Reports, 2023
Summary: Natural polyamines such as spermidine and spermine cations have characteristics that make them highly likely to be sensed by riboswitches, such as their general affinity to polyanionic RNA and their broad contributions to cell physiology ...
Hubert Salvail, Aparaajita Balaji, Adam Roth, Ronald R. Breaker   +3 more
doaj   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source