Results 61 to 70 of about 57,007 (201)

Analysis of spermidine’s effect on coronary heart disease risk using bidirectional Mendelian randomization and LC-MS/MS

Hereditas
Background This study examines the causal relationship between spermidine levels and coronary artery disease (CHD) risk using a bidirectional Mendelian Randomization (MR) approach.
Tianyi Wang, Li Lin, Yaodong Ding, Yang Zhang, Zehao Zhao, Ruixiang Feng, Yingxuan Bai, Zhennan Li, Yuncong Shi, Na Li, Yong Zeng   +10 more
doaj   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Spermidine dietary supplementation and polyamines level in reference to survival and lifespan of honey bees

Scientific Reports, 2023
Honey bee health has been an important and ongoing topic in recent years. Honey bee is also an important model organism for aging studies. Polyamines, putrescine, spermidine and spermine, are ubiquitous polycations, involved in a wide range of cellular ...
Srđana Đorđievski, Elvira L. Vukašinović, Tatjana V. Čelić, Ivan Pihler, Marko Kebert, Danijela Kojić, Jelena Purać   +6 more
doaj   +1 more source

Spermidine cures yeast of prions

, 2015
Prions are self-perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals. The molecular basis underlying their conversion from a normally soluble protein into the prion form remains largely unknown.
Shaun H. Speldewinde, Chris M. Grant, Chris Grant, Shaun Speldewinde   +3 more
core   +1 more source

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

Amino Acid and Biogenic Amine Profiles in Sausages Reformulated With Processed, Fermented Oyster Mushrooms

ChemFoodChem, EarlyView.
This research showed that sausage reformulation preserves high essential amino acid and branched‐chain amino acid content, as well as increasing free amino acids (FAA) related to umami flavor and health‐promoting components such as GABA in the products.
Albert Gashi, György Kenesei, Meltem Boylu Kovács, Zsuzsanna Mednyánszky, Livia Simon Sarkadi   +4 more
wiley   +1 more source

Characteristics of spermidine uptake by isolated rat enterocytes

, 1989
Eukaryotic cells require polyamines for growth. The supply of polyamines to growing cells may be increased either by new synthesis or increased uptake.
J. Kumagai, R. Jain, L. R. Johnson
core   +1 more source

Fixation Induces Mislocalization of Thin Filament Components in Caenorhabditis elegans Striated Muscle

Cytoskeleton, EarlyView.
ABSTRACT The simple nematode Caenorhabditis elegans has long served as a powerful genetic model system for studying muscle structure and function, with sarcomeres of the striated body wall muscle (BWM) that are considered largely homologous to those in vertebrates.
Michael J. Kimmich, Pu Zhang, Bob Goldstein, David Pruyne   +3 more
wiley   +1 more source

Spermidine improves the antioxidant capacity and morphology of intestinal tissues and regulates intestinal microorganisms in Sichuan white geese

Frontiers in Microbiology
IntroductionIntestinal health is very important to the health of livestock and poultry, and is even a major determining factor in the performance of livestock and poultry production.
Zelong Wang, Dongmei Jiang, Xin Wang, Yilong Jiang, Qian Sun, Weikang Ling, Xiaoguang An, Chengweng Ji, Shuo Li, Yuxin Qi, Bo Kang   +10 more
doaj   +1 more source

Spermidine Modulated Ribonuclease Activity Probed by RNA Plasmon Rulers

, 2008
We extend the scope of nanometer distance measurements based on coupled pairs of gold nanoparticles, or plasmon rulers, to individual RNA molecules.
Björn M. Reinhard (8669154), Lynell R. Skewis (2415493)   +1 more
core   +1 more source