Results 61 to 70 of about 92,235 (298)

Single‐Injection Multi‐Omics Analysis by Direct Infusion Mass Spectrometry

Angewandte Chemie, EarlyView.
A high‐throughput direct infusion mass spectrometry platform, enabled by gas‐phase ion mobility separation, supports single‐injection analysis of peptides, polar metabolites, and lipids. Coupled with custom software, it identified ∽1,300 proteins and ∽600 metabolites in ∽4.3 minutes per sample, and demonstrated broad utility in macrophage polarization ...
Yuming Jiang, Ivan Salladay‐Perez, Amanda Momenzadeh, Jesús Muñoz‐Estrada, Uktarsh Tripathi, Anthony J. Covarrubias, Jesse G. Meyer   +6 more
wiley   +2 more sources

Natural Polyamine Spermidine Inhibits the In Vitro Oxidation of LDL

Molecules
Spermidine is a natural autophagy-inducer and anti-aging compound. Herein, we investigated a potential autophagy-independent mechanism of spermidine, namely its capability to directly impede LDL oxidation, an early step in atherogenesis.
Christine Rossmann, Azra Darko, Gerd Kager, Gerhard Ledinski, Willibald Wonisch, Thomas Wagner, Seth Hallström, Gilbert Reibnegger, Margret Paar, Gerhard Cvirn   +9 more
doaj   +1 more source

Spermidine-Regulated Biosynthesis of Heat-Stable Antifungal Factor (HSAF) in Lysobacter enzymogenes OH11

Frontiers in Microbiology, 2018
Heat-Stable Antifungal Factor (HSAF) and its analogs are antifungal natural products produced by the biocontrol agent Lysobacter enzymogenes. The production of HSAF is greatly influenced by environmental stimuli and nutrients, but the underlying ...
Yuan Chen, Yuan Chen, Lingjun Yu, Lingjun Yu, Fengquan Liu, Liangcheng Du   +5 more
doaj   +1 more source

Investigation into the Relationship between Spermidine Degradation and Phenolic Compounds Biosynthesis in Barley Seedlings under Ultraviolet B Stress

Plants, 2023
Barley germination under ultraviolet B (UV-B) illumination stress induces effective accumulation of phenolic compounds in the barley. Spermidine can enhance the biosynthesis of phenolic compounds and alleviate the oxidative damage caused by UV-B.
Chong Xie, Yahui Zhu, Chaoqun Leng, Qiaoe Wang, Pei Wang, Runqiang Yang   +5 more
doaj   +1 more source

Abrupt Transition from a Free, Repulsive to a Condensed, Attractive DNA Phase, Induced by Multivalent Polyamine Cations

, 2008
We have investigated the energetics of DNA condensation by multivalent polyamine cations. Solution small angle x-ray scattering was used to monitor interactions between short 25 base pair dsDNA strands in the free supernatant DNA phase that coexists with
Andresen, Kurt, Kwok, Lisa W., Lamb, Jessica S., Pollack, Lois, Qiu, Xiangyun   +4 more
core   +1 more source

Dietary spermidine for lowering high blood pressure [PDF]

, 2017
Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease.
Abdellatif, Mahmoud, Carmona-Gutierrez, Didac, Dammbrueck, Christopher, Dengjel, Jörn, Eisenberg, Tobias, Gross, Angelina S., Harger, Alexandra, Herbst, Viktoria, Kiechl, Stefan, Kroemer, Guido, Linke, Wolfgang A., Madeo, Frank, Magnes, Christoph, Mühlfeld, Christian, Pendl, Tobias, Pieber, Thomas R., Pietrocola, Federico, Ruckenstuhl, Christoph, Sadoshima, Junichi, Schipke, Julia, Schmidt, Albrecht, Schroeder, Sabrina, Sedej, Simon, Sigrist, Stephan J., Stekovic, Slaven, Zimmermann, Andreas   +25 more
core   +3 more sources

Regulating T cell differentiation through the polyamine spermidine.

Journal of Allergy and Clinical Immunology, 2020
BACKGROUND The cross-talk between the host and its microbiota plays a key role in the promotion of health. The production of metabolites, such as polyamines, by intestinal-resident bacteria is part of this symbiosis shaping host immunity.
Guilhermina M. Carriche, Luís Almeida, Philipp Stüve, L. Velasquez, Ayesha Dhillon-LaBrooy, Urmi Roy, M. Lindenberg, T. Strowig, C. Plaza-Sirvent, I. Schmitz, M. Lochner, A. Simon, T. Sparwasser   +12 more
semanticscholar   +1 more source

Stimuli‐Responsive Silsesquioxane Nanozymes for Organocatalysis in Water and Prodrug Activation in Cells

Angewandte Chemie, EarlyView.
Amino‐bearing silsesquioxanes are water‐stable nanozymes that exhibit aggregation‐ and disaggregation‐dependent catalysis and can be applied to intracellular prodrug activation for cancer therapy. ABSTRACT Synthetic nanozymes have emerged as promising alternatives to natural enzymes for catalytic and therapeutic applications, yet their limited ...
Rabia Zahid, Ariadna Lázaro, Guillermo Moreno‐Alcántar, María Sancho‐Albero, Pierre Picchetti   +4 more
wiley   +2 more sources

Exogenous Spermidine Promotes Germination of Aged Sorghum Seeds by Mediating Sugar Metabolism

Plants, 2022
Starch, a substance stored in seeds, is the main source of energy for germination in sorghum seeds. However, as the seeds age, the catabolism of seed starch is affected, thereby seriously damaging germination ability.
Min Zhang, Bang Li, Zuliang Wan, Xiaofei Chen, Chang Liu, Chunjuan Liu, Yufei Zhou   +6 more
doaj   +1 more source

The pulling force of a single DNA molecule condensed by spermidine

, 2004
In a recent experiment, a single DNA double helix is stretched and relaxed in the presence of spermidine, a short positive polyelectrolyte, and the pulling force is measured as a function of DNA extension.
Alberts, B.I. Shklovskii, Bloomfield, Grosberg, Marko, Murayama, Nguyen, Olvera de la Cruz, Raspaud, Rouzina, Rui Zhang, Saminathan, Wada   +12 more
core   +1 more source