Results 1 to 10 of about 41,546 (228)
Advanced ScienceDecreased plasma spermine levels are associated with kidney dysfunction. However, the role of spermine in kidney disease remains largely unknown. Herein, it is demonstrated that spermine oxidase (SMOX), a key enzyme governing polyamine metabolism, is ...
Haiping Mao
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Animal Nutrition, 2017 Oxidative stress can damage cellular antioxidant defense and reduce livestock production efficiency. Spermine is a ubiquitous cellular component that plays important roles in stabilizing nucleic acids, modulating cell growth and differentiation, and ...
Caimei Wu, Hua Zhao, Xiaoling Chen
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Cell Communication and Signaling, 2022 Background Spermine is frequently elevated in tumor tissues and body fluids of cancer patients and is critical for cancer cell proliferation, migration and invasion.
Hong-Xiang Shi +11 more
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The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies
International Journal of Molecular Sciences, 2022 Polyamines are essential biomolecules for normal cellular metabolism in humans. The roles of polyamines in cancer development have been widely discussed in recent years.
Peter Ka-Fung Chiu +2 more
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Cellular and Molecular Life Sciences, 2009 Spermine is present in many organisms including animals, plants, some fungi, some archaea, and some bacteria. It is synthesized by spermine synthase, a highly specific aminopropyltransferase. This review describes spermine synthase structure, genetics, and function.
, Michael Anthony J, Pegg Anthony E
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Redox Biology, 2020 Diabetic cardiomyopathy (DCM) is a severe complication of type 1 diabetic (T1D) patients, manifested as combined diastolic and systolic dysfunction. DCM is associated with impaired calcium homeostasis secondary to decreased calcium-sensitive receptor ...
Yuehong Wang +12 more
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Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
Cell Reports, 2023 Summary: In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling.
Cheng Luo, Haotian Guo, Huili Shi
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Food Chemistry, 2018 Spermine and spermidine are polyamines (PA) naturally present in all organisms, in which they have important physiological functions. However, an excess of PA has been associated with health risks.
Patricia Ruas-Madiedo +2 more
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The MFS transporter BcTpo1 governs the oxidative stress response and infection of Botrytis cinerea [PDF]
Crop HealthBotrytis cinerea is a devastating necrotrophic pathogen causing gray mold disease. Understanding its pathogenic mechanisms is critical for developing novel control strategies. In this study, we investigated the role of spermine and its transporter BcTpo1
Lingchao Wang +5 more
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Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration [PDF]
Nature CommunicationsSpermine, a pivotal player in biomolecular condensation and diverse cellular processes, has emerged as a focus of investigation in aging, neurodegeneration, and other diseases.
Xun Sun +9 more
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