Results 1 to 10 of about 47,029 (206)
Cellular and Molecular Life Sciences, 2009 Spermine is present in many organisms including animals, plants, some fungi, some archaea, and some bacteria. It is synthesized by spermine synthase, a highly specific aminopropyltransferase. This review describes spermine synthase structure, genetics, and function.
Anthony J Michael
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Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration [PDF]
Nature CommunicationsSpermine, a pivotal player in biomolecular condensation and diverse cellular processes, has emerged as a focus of investigation in aging, neurodegeneration, and other diseases.
Xun Sun +9 more
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Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
Cell Reports, 2023 Summary: In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling.
Cheng Luo
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The MFS transporter BcTpo1 governs the oxidative stress response and infection of Botrytis cinerea [PDF]
Crop HealthBotrytis cinerea is a devastating necrotrophic pathogen causing gray mold disease. Understanding its pathogenic mechanisms is critical for developing novel control strategies. In this study, we investigated the role of spermine and its transporter BcTpo1
Lingchao Wang +5 more
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Redox Biology, 2020 Diabetic cardiomyopathy (DCM) is a severe complication of type 1 diabetic (T1D) patients, manifested as combined diastolic and systolic dysfunction. DCM is associated with impaired calcium homeostasis secondary to decreased calcium-sensitive receptor ...
Yuehong Wang, Jing Hu, Yajun Zhao
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Advanced ScienceDecreased plasma spermine levels are associated with kidney dysfunction. However, the role of spermine in kidney disease remains largely unknown. Herein, it is demonstrated that spermine oxidase (SMOX), a key enzyme governing polyamine metabolism, is ...
Haiping Mao, Qinghua Liu, Kefei Wu
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Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer [PDF]
Nature CommunicationsWhile dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic cancer patients
Hanshen Yang +21 more
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Spermine treatment improves salinity tolerance in Plantago major by altering growth parameters, biochemical profiles and gene expression [PDF]
Scientific ReportsSalinity is one of the most challenging environmental factors limiting plant development and yield by interfering with key physiological and metabolic activities.
Md Mukhtar Hossain +3 more
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Animal Nutrition, 2022 Weaning stress can cause tight junctions damage and intestinal permeability enhancement, which leads to intestinal imbalance and growth retardation, thereby causing damage to piglet growth and development. Spermine can reduce stress.
Guangmang Liu +8 more
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Biomedicines, 2023 The relationship between polyamines and healthy longevity has received much attention in recent years. However, conducting research without understanding the properties of polyamines can lead to unexpected pitfalls.
Kuniyasu Soda
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