Results 1 to 10 of about 33,328 (231)
Cellular and Molecular Life Sciences, 2009 Spermine is present in many organisms including animals, plants, some fungi, some archaea, and some bacteria. It is synthesized by spermine synthase, a highly specific aminopropyltransferase. This review describes spermine synthase structure, genetics, and function.
exaly +3 more sources
Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
Cell Reports, 2023 Summary: In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling.
Cheng Luo, Haotian Guo
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Preliminary study on the effects of different dietary spermine levels on intestinal function, microflora, and metabolism in weaned Wuzhishan piglets [PDF]
Frontiers in Veterinary ScienceBackgroundSpermine has been shown to promote intestinal maturation and protect intestinal health. However, its potential as a dietary feed additive for improving intestinal health in Wuzhishan piglets remains unclear.
Xinyu Xue +11 more
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The function of spermine [PDF]
IUBMB Life, 2014 Polyamines play important roles in cell physiology including effects on the structure of cellular macromolecules, gene expression, protein function, nucleic acid and protein synthesis, regulation of ion channels, and providing protection from oxidative damage.
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Spermine suppresses Salmonella-induced macrophage innate immune responses via inhibition of the cGAS-STING and TLR4 pathways [PDF]
mBioPolyamines integrate metabolism with innate immunity; however, their antibacterial roles remain unresolved. Here, we show that spermine suppresses innate immune responses against Salmonella enterica serovar Typhimurium infection in macrophages. Exogenous
Xiao Wang +10 more
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The MFS transporter BcTpo1 governs the oxidative stress response and infection of Botrytis cinerea [PDF]
Crop HealthBotrytis cinerea is a devastating necrotrophic pathogen causing gray mold disease. Understanding its pathogenic mechanisms is critical for developing novel control strategies. In this study, we investigated the role of spermine and its transporter BcTpo1
Lingchao Wang +5 more
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Animal Nutrition, 2022 Weaning stress can cause tight junctions damage and intestinal permeability enhancement, which leads to intestinal imbalance and growth retardation, thereby causing damage to piglet growth and development. Spermine can reduce stress.
Guangmang Liu +8 more
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Biomedicines, 2023 The relationship between polyamines and healthy longevity has received much attention in recent years. However, conducting research without understanding the properties of polyamines can lead to unexpected pitfalls.
Kuniyasu Soda
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Prostate International, 2023 Objectives: To investigate the role of urine spermine and spermine risk score in predicting prostate cancer (PCa) diagnoses in combination with multiparametric magnetic resonance imaging (mpMRI).
Shuji Isotani +13 more
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Oral Spermine Supplementation in Gestated Rabbit: A Study on Villi Height of Immature Intestines
Frontiers in Surgery, 2021 Introduction: Immature intestines are the major problem in prematurity. Postnatal oral spermine has been shown in studies to improve intestinal maturation in rats and piglets.
Riana Pauline Tamba, Yefta Moenadjat
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