Results 1 to 10 of about 34,064 (250)

Spermine and L-name pretreatment effects on polyamine and nitric oxide metabolism in rat brain during seizures [PDF]

Journal of Medical Biochemistry, 2007
In the CNS polyamines can exert opposite effects, depending on the concentration and conditions in the cell. Protective or neurotoxic polyamine effects were documented during seizures and repeated CNS excitation.
Stojanović Ivana, Jelenković Ankica, Vasiljević Ivana, Pavlović Dušica, Bjelaković Gordana   +4 more
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Effects of spermine on immune organ indexes and expression levels of genes related to immune factors in geese

浙江大学学报. 农业与生命科学版, 2019
To investigate the effects of spermine on goose immune organ indexes and expression levels of genes related to immune factors, the Sichuan adult white geese (female) were intragastrically administered with 5 and 10 mg spermine per kilogram body mass, and
YI Zhixin, JIANG Yilong, WANG Qiuhong, XU Qilin, WANG Xinxing, MO Guilin, JIANG Dongmei, KANG Bo   +7 more
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Bacterial infection reinforces host metabolic flux from arginine to spermine for NLRP3 inflammasome evasion

Cell Reports, 2021
Summary: Hosts recognize cytosolic microbial infection via the nucleotide-binding domain-like receptor (NLR) protein family, triggering inflammasome complex assembly to provoke pyroptosis or cytokine-related caspase-1-dependent antimicrobial responses ...
Jiatiao Jiang, Wenwen Wang, Fei Sun, Yuanxing Zhang, Qin Liu, Dahai Yang   +5 more
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Overexpression of SAMDC1 gene in Arabidopsis thaliana increases expression of defense-related genes as well as resistance to Pseudomonas syringae and Hyaloperonospora arabidopsidis

Frontiers in Plant Science, 2014
It has been previously described that elevation of endogenous spermine levels in Arabidopsis could be achieved by transgenic overexpression of S-Adenosylmethionine decarboxylase (SAMDC) or Spermine synthase (SPMS).
Francisco eMarco, Enrique eBusó, Pedro eCarrasco   +2 more
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Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration

Nature Communications
Spermine, a pivotal player in biomolecular condensation and diverse cellular processes, has emerged as a focus of investigation in aging, neurodegeneration, and other diseases.
Xun Sun, Debasis Saha, Xue Wang, Cecilia Mörman, Rebecca Sternke-Hoffmann, Juan Atilio Gerez, Fátima Herranz-Trillo, Roland Riek, Wenwei Zheng, Jinghui Luo   +9 more
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Dose-Dependent Effect of the Polyamine Spermine on Wheat Seed Germination, Mycelium Growth of Fusarium Seed-Borne Pathogens, and In Vivo Fusarium Root and Crown Rot Development

Agriculture
Wheat (Triticum aestivum L.) is a crucial global food crop. The intensive crop farming, monoculture cultivation, and impact of climate change affect the susceptibility of wheat cultivars to biotic stresses, mainly caused by soil fungal pathogens ...
Tsvetina Nikolova, Dessislava Todorova, Tzenko Vatchev, Zornitsa Stoyanova, Valya Lyubenova, Yordanka Taseva, Ivo Yanashkov, Iskren Sergiev   +7 more
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Spermine modulates fungal morphogenesis and activates plasma membrane H+-ATPase during yeast to hyphae transition

Biology Open, 2018
Polyamines play a regulatory role in eukaryotic cell growth and morphogenesis. Despite many molecular advances, the underlying mechanism of action remains unclear.
Antônio Jesus Dorighetto Cogo, Keilla dos Reis Dutra Ferreira, Lev A. Okorokov, Alessandro C. Ramos, Arnoldo R. Façanha, Anna L. Okorokova-Façanha   +5 more
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Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer

Nature Communications
While dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic cancer patients
Hanshen Yang, Xiaozhen Zhang, Sirui Zhang, Yanqing Yang, Yan Chen, Yangwei Jiang, Qingsong Lu, Lingyue Liu, Mengyi Lao, Weiran Du, Kang Sun, Lihong He, Jiatao Shi, Xinyuan Liu, Jinyuan Song, Na Lu, Junming Huang, Jinyan Huang, Ruhong Zhou, Xiongbin Lu, Tingbo Liang, Xueli Bai   +21 more
doaj   +1 more source

Polyamine stress at high pH in Escherichia coli K-12

BMC Microbiology, 2005
Background Polyamines such as spermine and spermidine are required for growth of Escherichia coli; they interact with nucleic acids, and they bind to ribosomes. Polyamines block porins and decrease membrane permeability, activities that may protect cells
Tate Daniel P, Wilks Jessica C, Thurber Amy E, Yohannes Elizabeth, Slonczewski Joan L   +4 more
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Spermine inhibits Endoplasmic Reticulum Stress - induced Apoptosis: a New Strategy to Prevent Cardiomyocyte Apoptosis

Cellular Physiology and Biochemistry, 2016
Background/Aims: Endoplasmic reticulum stress (ERS) plays an important role in the progression of acute myocardial infarction (AMI), in part by mediating apoptosis.
Can Wei, Yuehong Wang, Meixiu Li, Hongzhu Li, Xiaoxiao Lu, Hongjiang Shao, Changqing Xu   +6 more
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