Results 11 to 20 of about 34,064 (250)

The Spermine Oxidase/Spermine Axis Coordinates ATG5-Mediated Autophagy to Orchestrate Renal Senescence and Fibrosis

Advanced Science
Decreased plasma spermine levels are associated with kidney dysfunction. However, the role of spermine in kidney disease remains largely unknown. Herein, it is demonstrated that spermine oxidase (SMOX), a key enzyme governing polyamine metabolism, is ...
Haiping Mao, Xianrui Dou, Xiaohui Lu
exaly   +3 more sources

Spermine Synthase at the Polyamine–Redox Interface: Mechanistic Evidence from Snyder–Robinson Syndrome and Cancer [PDF]

Antioxidants
Polyamines are essential metabolites whose biological effects depend on the balance among putrescine, spermidine, and spermine. Spermine synthase (SMS) catalyzes the terminal step of mammalian spermine biosynthesis, simultaneously consuming spermidine ...
Ziling Lin, Yuning Lin, Mingle Li, Songye Zhan, Qian Xu, Feiyuan Yu   +5 more
doaj   +2 more sources

Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer

Cell Reports, 2023
Summary: In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling.
Kaixian Chen, Cheng Luo, Hongru Tao
exaly   +3 more sources

Preliminary study on the effects of different dietary spermine levels on intestinal function, microflora, and metabolism in weaned Wuzhishan piglets [PDF]

Frontiers in Veterinary Science
BackgroundSpermine has been shown to promote intestinal maturation and protect intestinal health. However, its potential as a dietary feed additive for improving intestinal health in Wuzhishan piglets remains unclear.
Xinyu Xue, Xinyu Xue, Tao Tang, Haojie Zhang, Haojie Zhang, Limin Wei, Feng Wang, Zhe Chao, Hailong Liu, Yuwei Ren, Chengjun Hu, Ruiping Sun   +11 more
doaj   +2 more sources

New insights into the role of spermine in enhancing the antioxidant capacity of rat spleen and liver under oxidative stress

Animal Nutrition, 2017
Oxidative stress can damage cellular antioxidant defense and reduce livestock production efficiency. Spermine is a ubiquitous cellular component that plays important roles in stabilizing nucleic acids, modulating cell growth and differentiation, and ...
Caimei Wu, Hua Zhao, Xiaoling Chen
exaly   +3 more sources

Spermine suppresses Salmonella-induced macrophage innate immune responses via inhibition of the cGAS-STING and TLR4 pathways [PDF]

mBio
Polyamines integrate metabolism with innate immunity; however, their antibacterial roles remain unresolved. Here, we show that spermine suppresses innate immune responses against Salmonella enterica serovar Typhimurium infection in macrophages. Exogenous
Xiao Wang, Mohua Liu, Xiaoya Qu, Jing Hou, Shukun Chen, Tianyuan Chang, Jiayue Li, Jinglei Xia, Xihui Shen, Yao Wang, Lei Xu   +10 more
doaj   +2 more sources

Spermine protects intestinal barrier integrity through ras-related C3 botulinum toxin substrate 1/phospholipase C-γ1 signaling pathway in piglets

Animal Nutrition, 2022
Weaning stress can cause tight junctions damage and intestinal permeability enhancement, which leads to intestinal imbalance and growth retardation, thereby causing damage to piglet growth and development. Spermine can reduce stress.
Guangmang Liu, Xiaomei Xu, Caimei Wu, Gang Jia, Hua Zhao, Xiaoling Chen, Gang Tian, Jingyi Cai, Jing Wang   +8 more
doaj   +1 more source

Changes in Whole Blood Polyamine Levels and Their Background in Age-Related Diseases and Healthy Longevity

Biomedicines, 2023
The relationship between polyamines and healthy longevity has received much attention in recent years. However, conducting research without understanding the properties of polyamines can lead to unexpected pitfalls.
Kuniyasu Soda
doaj   +1 more source

Spermine-Conjugated Short Proline-Rich Lipopeptides as Broad-Spectrum Intracellular Targeting Antibacterial Agents

, 2022
Toward the design of new proline-rich peptidomimetics, a short peptide segment, present in several proline-rich antimicrobial peptides (AMPs), was selected.
Saman Habib (41045), Jimut Kanti Ghosh (1992208), Rikeshwer Prasad Dewangan, Kalyan Mitra, Rikeshwer Prasad Dewangan (12255790), Devesh Pratap Verma (9249527), Devesh Pratap Verma, Ankit Gupta (211785), Jimut Kanti Ghosh, Neeraj Kumar Verma, Saman Habib, Kalyan Mitra (514430), Neeraj Kumar Verma (9249533), Ankit Gupta, Garima Pant, Garima Pant (9249536)   +15 more
core   +2 more sources

High-Resolution LC-MS/MS Characterization of Budmunchiamine-Type Alkaloids in Albizia niopoides. [PDF]

Rapid Commun Mass Spectrom
ABSTRACT Rationale Budmunchiamines are macrocyclic spermine alkaloids that constitute a distinctive class of polyamine natural products predominantly found in species of the genus Albizia. Comprehensive characterization of these compounds remains challenging because of their structural diversity and the limited availability of reference standards. This
Majevski MLA, D'Auria Lima L, Reis ACC, Santos LICR, Vargas BFS, Kohlhoff M, Brandão GC.   +6 more
europepmc   +2 more sources