Results 1 to 10 of about 44,043 (152)
Medical Sciences, 2022 Polyamines are small polycationic alkylamines involved in many fundamental cellular processes, including cell proliferation, survival, and protection from oxidative stress.
Cassandra E. Holbert +6 more
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Biomolecules, 2023 Polyamine homeostasis is disturbed in several human diseases, including cancer, which is hallmarked by increased intracellular polyamine levels and an upregulated polyamine transport system (PTS).
Sarah van Veen +7 more
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Biosensors, 2022 The biogenic aliphatic polyamines (spermine, spermidine, and putrescine) are responsible for numerous cell functions, including cell proliferation, the stabilization of nucleic acid conformations, cell division, homeostasis, gene expression, and protein ...
Bingli Lu +4 more
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Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity
Cells, 2022 Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent work has highlighted that polyamines exert profound roles on the mammalian immune system, particularly inflammation and cancer. The mechanisms by which they control
Tzu-yi Chia, Andrew Zolp, Jason Miska
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ATP13A3 facilitates polyamine transport in human pancreatic cancer cells
Scientific Reports, 2022 The purpose of this study is to provide an increased understanding of the molecular mechanisms responsible for mammalian polyamine transport, a process that has been a long-standing ‘black box’ for the polyamine field.
Vandana Sekhar +2 more
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Viruses, 2021 Enteroviruses, including Coxsackievirus B3 (CVB3), are pervasive pathogens that cause significant disease, including cardiomyopathies. Unfortunately, no treatments or vaccines are available for infected individuals.
Bridget M. Hulsebosch, Bryan C. Mounce
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Upregulation of Polyamine Transport in Human Colorectal Cancer Cells
Biomolecules, 2020 Polyamines are essential growth factors that have a positive role in cancer cell growth. Their metabolic pathway and the diverse enzymes involved have been studied in depth in multiple organisms and cells.
Misael Corral, Heather M. Wallace
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Animals, 2021 Emerging research suggests that hormones found in anabolic implants interact with polyamine biosynthesis. The objective of this study was to determine the effects of steroidal hormones, polyamines and polyamine precursors on bovine satellite cell (BSC ...
Caleb C. Reichhardt +5 more
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Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis. [PDF]
PLoS ONE, 2013 Polyamines (spermine and spermidine) play many important roles in cellular function and are supplied from the intestinal lumen. We have shown that continuous high polyamine intake inhibits age-associated pathologies in mice.
Kuniyasu Soda +4 more
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Polyamine–Drug Conjugates: Do They Boost Drug Activity?
Molecules, 2023 Over the past two decades, the strategy of conjugating polyamine tails with bioactive molecules such as anticancer and antimicrobial agents, as well as antioxidant and neuroprotective scaffolds, has been widely exploited to enhance their pharmacological ...
Filippo Basagni +3 more
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