Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy [PDF]
Medical Sciences, 2022 Polyamines are small polycationic alkylamines involved in many fundamental cellular processes, including cell proliferation, survival, and protection from oxidative stress.
Cassandra E. Holbert +6 more
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Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment [PDF]
Biosensors, 2022 The biogenic aliphatic polyamines (spermine, spermidine, and putrescine) are responsible for numerous cell functions, including cell proliferation, the stabilization of nucleic acid conformations, cell division, homeostasis, gene expression, and protein ...
Bingli Lu +4 more
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ARID1A deficiency-driven reprogramming of polyamine metabolism promotes endometrial cancer malignancy and immune escape [PDF]
Cell Death and DiseaseMetabolic reprogramming is crucial in developing endometrial cancer (EC); however, the mechanisms through which tumor suppressors control metabolites that drive cell proliferation and tumor growth remain unclear.
Han Tao +7 more
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Opposing Roles for ATP13A2 and ATP13A3 in Breast Cancer Subtype-Specific Polyamine Homeostasis [PDF]
BiomoleculesPolyamine homeostasis is essential for normal cellular function and is maintained through coordinated regulation of polyamine biosynthesis, catabolism, and transport.
Emily Meeus +3 more
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Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging [PDF]
Amino AcidsInterest in RNA editing has emerged in molecular medicine due to its widespread dysregulation and therapeutic potential. Its regulatory mechanisms in governing non-coding RNAs, especially microRNAs (miRNAs) remain largely unresolved. Emerging evidence in
Miora Bruna Marielle Ramamonjiharisoa +1 more
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Polyamine metabolism and anti-tumor immunity
Frontiers in ImmunologyGrowing attention has been directed toward the critical role of polyamines in the tumor microenvironment and immune regulation. Polyamines, primarily comprising putrescine, spermidine, and spermine, are tightly regulated through coordinated biosynthesis,
Chen Qi-Yue
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Biomolecules, 2023 Polyamine homeostasis is disturbed in several human diseases, including cancer, which is hallmarked by increased intracellular polyamine levels and an upregulated polyamine transport system (PTS).
Sarah van Veen +7 more
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ATP13A3 facilitates polyamine transport in human pancreatic cancer cells
Scientific Reports, 2022 The purpose of this study is to provide an increased understanding of the molecular mechanisms responsible for mammalian polyamine transport, a process that has been a long-standing ‘black box’ for the polyamine field.
Vandana Sekhar +2 more
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Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity
Cells, 2022 Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent work has highlighted that polyamines exert profound roles on the mammalian immune system, particularly inflammation and cancer. The mechanisms by which they control
Tzu-yi Chia, Andrew Zolp, Jason Miska
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Viruses, 2021 Enteroviruses, including Coxsackievirus B3 (CVB3), are pervasive pathogens that cause significant disease, including cardiomyopathies. Unfortunately, no treatments or vaccines are available for infected individuals.
Bridget M. Hulsebosch, Bryan C. Mounce
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