Results 11 to 20 of about 65,399 (230)
Polyamine–Drug Conjugates: Do They Boost Drug Activity? [PDF]
Molecules, 2023 Over the past two decades, the strategy of conjugating polyamine tails with bioactive molecules such as anticancer and antimicrobial agents, as well as antioxidant and neuroprotective scaffolds, has been widely exploited to enhance their pharmacological ...
Filippo Basagni +3 more
doaj +3 more sources
EBV-Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma. [PDF]
Adv Sci (Weinh)EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Li Y +9 more
europepmc +2 more sources
T<sub>H</sub>17-Associated Polyamine Metabolism-Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis. [PDF]
Adv Sci (Weinh)A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Zhu C +12 more
europepmc +2 more sources
Functionalized polyamine synthesis with photoredox catalysis [PDF]
, 2023 Polyamines, such as putrescine and spermidine, are pivotal in various biological processes across living organisms. Despite their significance, structurally modified polyamines offer a less-explored avenue for discovering bioactive compounds.
Yuta, Makihara +4 more
core +2 more sources
Animals, 2021 Emerging research suggests that hormones found in anabolic implants interact with polyamine biosynthesis. The objective of this study was to determine the effects of steroidal hormones, polyamines and polyamine precursors on bovine satellite cell (BSC ...
Caleb C. Reichhardt +5 more
doaj +1 more source
Biomedicines, 2023 Several mechanisms strictly regulate polyamine concentration, and blood polyamines are excreted in urine. This indicates polyamine accumulation in renal dysfunction, and studies have shown increased blood polyamine concentrations in patients with renal ...
Hidenori Sanayama +12 more
doaj +1 more source
Biomolecules, 2023 Cells acquire polyamines putrescine (PUT), spermidine (SPD) and spermine (SPM) via the complementary actions of polyamine uptake and synthesis pathways.
Marine Houdou +9 more
doaj +1 more source
Mathematical modelling of polyamine metabolism in bloodstream-form trypanosoma brucei: An application to drug target identification [PDF]
, 2013 © 2013 Gu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Desmond J Higham +16 more
core +2 more sources
Medical Sciences, 2017 Increased polyamine biosynthesis activity and an active polyamine transport system are characteristics of many cancer cell lines and polyamine depletion has been shown to be a viable anticancer strategy.
Minpei Wang +2 more
doaj +1 more source
, 2019 Diverse platinum drug candidates have been designed to improve inhibitory potency and overcome resistance for orthotopic tumors. However, the antimetastatic properties have rarely been reported.
Sitong Liu (3750979) +29 more
core +2 more sources