Results 11 to 20 of about 63,812 (294)
Medical Sciences, 2022 Polyamines are small polycationic alkylamines involved in many fundamental cellular processes, including cell proliferation, survival, and protection from oxidative stress.
Cassandra E. Holbert +6 more
doaj +4 more sources
Biosensors, 2022 The biogenic aliphatic polyamines (spermine, spermidine, and putrescine) are responsible for numerous cell functions, including cell proliferation, the stabilization of nucleic acid conformations, cell division, homeostasis, gene expression, and protein ...
Bingli Lu +4 more
doaj +2 more sources
Essays in Biochemistry, 2009 The polyamines are essential for a variety of functions in the mammalian cell. Although their specific effects have not been fully elucidated, it is clear that the cellular polyamines have to be kept within certain levels for normal cell function.
Persson, Lo
core +4 more sources
Development of Polyamine Lassos as Polyamine Transport Inhibitors
ACS Medicinal Chemistry Letters, 2022 Nine- and twelve-membered triaza-macrocycles were appended to one end of homospermidine to make polyamine lassos. These compounds were shown to be potent polyamine transport inhibitors (PTIs) using pancreatic ductal adenocarcinoma L3.6pl cells, which have high polyamine transport activity. The smaller triazacyclononane-based lasso significantly reduced
Aiste Dobrovolskaite +3 more
openaire +3 more sources
Biosynthesis of polyamines and polyamine-containing molecules
Biochemical Journal, 2016 Polyamines are evolutionarily ancient polycations derived from amino acids and are pervasive in all domains of life. They are essential for cell growth and proliferation in eukaryotes and are essential, important or dispensable for growth in bacteria.
openaire +3 more sources
Polyamine metabolism and anti-tumor immunity
Frontiers in ImmunologyGrowing attention has been directed toward the critical role of polyamines in the tumor microenvironment and immune regulation. Polyamines, primarily comprising putrescine, spermidine, and spermine, are tightly regulated through coordinated biosynthesis,
Jing-Yi Wu +3 more
exaly +3 more sources
ARID1A deficiency-driven reprogramming of polyamine metabolism promotes endometrial cancer malignancy and immune escape [PDF]
Cell Death and DiseaseMetabolic reprogramming is crucial in developing endometrial cancer (EC); however, the mechanisms through which tumor suppressors control metabolites that drive cell proliferation and tumor growth remain unclear.
Han Tao +7 more
doaj +2 more sources
EBV-Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma. [PDF]
Adv Sci (Weinh)EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Li Y +9 more
europepmc +2 more sources
Molecular OncologyHigh‐risk neuroblastomas, often associated with MYCN protooncogene amplification, are addicted to polyamines, small polycations vital for cellular functioning.
Mujahid Azfar +19 more
doaj +2 more sources
T<sub>H</sub>17-Associated Polyamine Metabolism-Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis. [PDF]
Adv Sci (Weinh)A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Zhu C +12 more
europepmc +2 more sources