Results 31 to 40 of about 63,812 (294)
Animals, 2021 Emerging research suggests that hormones found in anabolic implants interact with polyamine biosynthesis. The objective of this study was to determine the effects of steroidal hormones, polyamines and polyamine precursors on bovine satellite cell (BSC ...
Caleb C. Reichhardt +5 more
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Polyamine–Drug Conjugates: Do They Boost Drug Activity?
Molecules, 2023 Over the past two decades, the strategy of conjugating polyamine tails with bioactive molecules such as anticancer and antimicrobial agents, as well as antioxidant and neuroprotective scaffolds, has been widely exploited to enhance their pharmacological ...
Filippo Basagni +3 more
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Biomedicines, 2023 Several mechanisms strictly regulate polyamine concentration, and blood polyamines are excreted in urine. This indicates polyamine accumulation in renal dysfunction, and studies have shown increased blood polyamine concentrations in patients with renal ...
Hidenori Sanayama +12 more
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Biomolecules, 2023 Cells acquire polyamines putrescine (PUT), spermidine (SPD) and spermine (SPM) via the complementary actions of polyamine uptake and synthesis pathways.
Marine Houdou +9 more
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Mathematical modelling of polyamine metabolism in bloodstream-form trypanosoma brucei: An application to drug target identification [PDF]
, 2013 © 2013 Gu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Desmond J Higham +16 more
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Polyamines and apoptosis [PDF]
Journal of Cellular and Molecular Medicine, 2005 The natural polyamines putrescine, spermidine and spermine are in multiple ways involved in cell growth and the maintenance of cell viability. In the course of the last 15 years more and more evidence hinted also at roles in gene regulation. It is therefore not surprising that the polyamines are involved in events inherent to genetically programmed ...
Nikolaus, Seiler, Francis, Raul
openaire +2 more sources
Medical Sciences, 2017 Increased polyamine biosynthesis activity and an active polyamine transport system are characteristics of many cancer cell lines and polyamine depletion has been shown to be a viable anticancer strategy.
Minpei Wang +2 more
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, 2019 Diverse platinum drug candidates have been designed to improve inhibitory potency and overcome resistance for orthotopic tumors. However, the antimetastatic properties have rarely been reported.
Sitong Liu (3750979) +29 more
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Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers
Medical Sciences, 2017 Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC).
Chelsea Massaro +2 more
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Frontiers in Nutrition, 2019 The polyamines spermine, spermidine, and putrescine are involved in various biological processes, notably in cell proliferation and differentiation, and also have antioxidant properties. Dietary polyamines have important implications in human health, mainly in the intestinal maturation and in the differentiation and development of immune system.
Nelly C. Muñoz-Esparza +15 more
openaire +4 more sources