Results 1 to 10 of about 29,877 (250)

Polyamine metabolism and anti-tumor immunity [PDF]

Frontiers in Immunology
Growing attention has been directed toward the critical role of polyamines in the tumor microenvironment and immune regulation. Polyamines, primarily comprising putrescine, spermidine, and spermine, are tightly regulated through coordinated biosynthesis,
Jing-Yi Wu, Yan Zeng, Yu-Yang You, Qi-Yue Chen   +3 more
doaj   +6 more sources

Subtype‐Specific Transcription Factors Affect Polyamine Metabolism and the Tumor Microenvironment in Breast Cancer [PDF]

Cancer Innovation
Background Polyamines play important roles in cell growth and proliferation. Polyamine metabolism genes are dysregulated in various tumors. Some polyamine metabolism genes are regulated by transcription factors.
Qi Song, Yixuan Wang, Sen Liu
doaj   +4 more sources

Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages [PDF]

Smart Medicine
Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma pathogenesis.
Haoran Ding, Lingling Xue, Shaoshi Zhu, Ziyu Wang, Huan Gui, Guang Zhang, Ning Tang, Haozhen Ren, Dayu Chen   +8 more
doaj   +3 more sources

Polyamine metabolism changes in psoriasis

Indian Journal of Dermatology, 2013
Introduction: Polyamines - putrescine, spermidine and spermine are polycationic compounds ubiquitous for all living organisms. They are essential for the cell growth and differentiation, the control of cell cycle progress, apoptosis, and cancerogenesis ...
Valentina Broshtilova, Valentina Lozanov, Ljubka Miteva   +2 more
doaj   +4 more sources

Heterogeneity in polyamine metabolism dictates prognosis and immune checkpoint blockade response in hepatocellular carcinoma [PDF]

Frontiers in Immunology
Immune checkpoint blockade holds promise in hepatocellular carcinoma (HCC) treatment, but its efficacy remains limited. Dysregulated polyamine metabolism and its interaction with oncogenic pathways promote tumor progression. However, the heterogeneity of
Jianyan Pan, Zhong Lin, Qinchun Pan, Tao Zhu   +3 more
doaj   +4 more sources

Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers

Medical Sciences, 2017
Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC).
Chelsea Massaro, Jenna Thomas, Otto Phanstiel   +2 more
doaj   +4 more sources

Influence of a phyA Mutation on Polyamine Metabolism in Arabidopsis Depends on Light Spectral Conditions

Plants, 2023
The aim of the study was to reveal the influence of phyA mutations on polyamine metabolism in Arabidopsis under different spectral compositions. Polyamine metabolism was also provoked with exogenous spermine.
Altafur Rahman, Judit Tajti, Imre Majláth, Tibor Janda, Sylva Prerostova, Mohamed Ahres, Magda Pál   +6 more
doaj   +2 more sources

The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment

Frontiers in Immunology, 2022
The study of metabolism provides important information for understanding the biological basis of cancer cells and the defects of cancer treatment. Disorders of polyamine metabolism is a common metabolic change in cancer.
Jiachun Lian, Jiachun Lian, Yanfang Liang, Hailiang Zhang, Hailiang Zhang, Minsheng Lan, Ziyu Ye, Ziyu Ye, Ziyu Ye, Bihua Lin, Bihua Lin, Bihua Lin, Xianxiu Qiu, Xianxiu Qiu, Xianxiu Qiu, Jincheng Zeng, Jincheng Zeng, Jincheng Zeng, Jincheng Zeng   +18 more
doaj   +3 more sources

Polyamine metabolism and obesity: Polyamine metabolic enzymes involved in obesity [PDF]

ACTA Pharmaceutica Sciencia, 2018
The natural polyamines, putrescine, spermidine and spermine are distributed widely in all cells including adipocytes. They are involved in several physiological processes involving gene expression and cell proliferation.
Büyükuslu, Nihal, Öztürk, Rabia İclal   +1 more
core   +4 more sources

One-Carbon and Polyamine Metabolism as Cancer Therapy Targets

Biomolecules, 2022
Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid replication. A common target of this metabolic reprogramming is one-carbon metabolism which is notable for its function in DNA synthesis, protein and DNA ...
Anowarul Islam, Zeeshan Shaukat, Rashid Hussain, Stephen L. Gregory   +3 more
doaj   +2 more sources