Results 1 to 10 of about 677 (66)

Polyamine metabolism and anti-tumor immunity

Frontiers in Immunology
Growing attention has been directed toward the critical role of polyamines in the tumor microenvironment and immune regulation. Polyamines, primarily comprising putrescine, spermidine, and spermine, are tightly regulated through coordinated biosynthesis,
Jing-Yi Wu, Yan Zeng, Yu-Yang You, Qi-Yue Chen   +3 more
doaj   +3 more sources

Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages

Smart Medicine
Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma pathogenesis.
Haoran Ding, Lingling Xue, Shaoshi Zhu, Ziyu Wang, Huan Gui, Guang Zhang, Ning Tang, Haozhen Ren, Dayu Chen   +8 more
doaj   +2 more sources

Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers

Medical Sciences, 2017
Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC).
Chelsea Massaro, Jenna Thomas, Otto Phanstiel   +2 more
doaj   +3 more sources

Antizyme Inhibitors in Polyamine Metabolism and Beyond: Physiopathological Implications

Medical Sciences, 2018
The intracellular levels of polyamines, cationic molecules involved in a myriad of cellular functions ranging from cellular growth, differentiation and apoptosis, is precisely regulated by antizymes and antizyme inhibitors via the modulation of the ...
Bruno Ramos-Molina, Ana Lambertos, Rafael Peñafiel   +2 more
doaj   +3 more sources

The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment

Frontiers in Immunology, 2022
The study of metabolism provides important information for understanding the biological basis of cancer cells and the defects of cancer treatment. Disorders of polyamine metabolism is a common metabolic change in cancer.
Jiachun Lian, Jiachun Lian, Yanfang Liang, Hailiang Zhang, Hailiang Zhang, Minsheng Lan, Ziyu Ye, Ziyu Ye, Ziyu Ye, Bihua Lin, Bihua Lin, Bihua Lin, Xianxiu Qiu, Xianxiu Qiu, Xianxiu Qiu, Jincheng Zeng, Jincheng Zeng, Jincheng Zeng, Jincheng Zeng   +18 more
doaj   +1 more source

Investigation of The Roles of Hydrogen Peroxide and NADPH Oxidase in The Regulation of Polyamine Metabolism in Maize Plants under Drought Stress Conditions

Journal of Agricultural Sciences, 2022
The relationship between hydrogen peroxide and the metabolism of polyamines and the role of NADPH oxidase (NOX) in that relationship under drought conditions remains unclear.
Aykut Sağlam, Mehmet Demiralay, Fuat Yetişsin, Asım Kadıoğlu   +3 more
doaj   +1 more source

Influence of a phyA Mutation on Polyamine Metabolism in Arabidopsis Depends on Light Spectral Conditions

Plants, 2023
The aim of the study was to reveal the influence of phyA mutations on polyamine metabolism in Arabidopsis under different spectral compositions. Polyamine metabolism was also provoked with exogenous spermine.
Altafur Rahman, Judit Tajti, Imre Majláth, Tibor Janda, Sylva Prerostova, Mohamed Ahres, Magda Pál   +6 more
doaj   +1 more source

One-Carbon and Polyamine Metabolism as Cancer Therapy Targets

Biomolecules, 2022
Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid replication. A common target of this metabolic reprogramming is one-carbon metabolism which is notable for its function in DNA synthesis, protein and DNA ...
Anowarul Islam, Zeeshan Shaukat, Rashid Hussain, Stephen L. Gregory   +3 more
doaj   +1 more source

Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity

Cells, 2022
Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent work has highlighted that polyamines exert profound roles on the mammalian immune system, particularly inflammation and cancer. The mechanisms by which they control
Tzu-yi Chia, Andrew Zolp, Jason Miska
doaj   +1 more source

Polyamines and related signaling pathways in cancer

Cancer Cell International, 2020
Polyamines are aliphatic compounds with more than two amino groups that play various important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs, and regulatory mechanisms of polyamine.
Jiajing Li, Yan Meng, Xiaolin Wu, Yuxin Sun   +3 more
doaj   +1 more source