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Polyamine metabolism and anti-tumor immunity [PDF]

Frontiers in Immunology
Growing attention has been directed toward the critical role of polyamines in the tumor microenvironment and immune regulation. Polyamines, primarily comprising putrescine, spermidine, and spermine, are tightly regulated through coordinated biosynthesis,
Jing-Yi Wu, Yan Zeng, Yu-Yang You, Qi-Yue Chen   +3 more
doaj   +5 more sources

The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment

Frontiers in Immunology, 2022
The study of metabolism provides important information for understanding the biological basis of cancer cells and the defects of cancer treatment. Disorders of polyamine metabolism is a common metabolic change in cancer.
Jiachun Lian, Jiachun Lian, Yanfang Liang, Hailiang Zhang, Hailiang Zhang, Minsheng Lan, Ziyu Ye, Ziyu Ye, Ziyu Ye, Bihua Lin, Bihua Lin, Bihua Lin, Xianxiu Qiu, Xianxiu Qiu, Xianxiu Qiu, Jincheng Zeng, Jincheng Zeng, Jincheng Zeng, Jincheng Zeng   +18 more
doaj   +4 more sources

Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages [PDF]

Smart Medicine
Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma pathogenesis.
Haoran Ding, Lingling Xue, Shaoshi Zhu, Ziyu Wang, Huan Gui, Guang Zhang, Ning Tang, Haozhen Ren, Dayu Chen   +8 more
doaj   +3 more sources

Subtype‐Specific Transcription Factors Affect Polyamine Metabolism and the Tumor Microenvironment in Breast Cancer [PDF]

Cancer Innovation
Background Polyamines play important roles in cell growth and proliferation. Polyamine metabolism genes are dysregulated in various tumors. Some polyamine metabolism genes are regulated by transcription factors.
Qi Song, Yixuan Wang, Sen Liu
doaj   +3 more sources

Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV

Nature Communications, 2023
Polyamine metabolism is a determinant of T helper cell polarization. Here, Mahalingam et al analyse the metabolic and transcriptomic profile of oral mucosa from people living with HIV to demonstrate the effect of polyamine synthesis on T cell dysfunction
S. S. Mahalingam, S. Jayaraman, N. Bhaskaran, E. Schneider, F. Faddoul, A. Paes da Silva, M. M. Lederman, R. Asaad, K. Adkins-Travis, L. P. Shriver, P. Pandiyan   +10 more
doaj   +2 more sources

One-Carbon and Polyamine Metabolism as Cancer Therapy Targets

Biomolecules, 2022
Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid replication. A common target of this metabolic reprogramming is one-carbon metabolism which is notable for its function in DNA synthesis, protein and DNA ...
Anowarul Islam, Zeeshan Shaukat, Rashid Hussain, Stephen L. Gregory   +3 more
doaj   +2 more sources

Expanded Potential of the Polyamine Analogue SBP-101 (Diethyl Dihydroxyhomospermine) as a Modulator of Polyamine Metabolism and Cancer Therapeutic

International Journal of Molecular Sciences, 2022
Naturally occurring polyamines are absolutely required for cellular growth and proliferation. Many neoplastic cells are reliant on elevated polyamine levels and maintain these levels through dysregulated polyamine metabolism.
Robert A Casero, Tracy Murray Stewart, Cassandra E Holbert   +2 more
exaly   +2 more sources

Comprehensive analysis of the clinical and biological significances of polyamine metabolism in glioma [PDF]

Discover Oncology
Polyamines, including spermidine, spermine, and putrescine, are polycationic alkylamines in mammalian cells. However, the prognostic impact of polyamine in glioma remains unclear.
Fei Bai, Kexin Zhai, Tiantian Yao, Yuxia Zhou, Yongxiang Zhao, Guanghui Yang   +5 more
doaj   +2 more sources

Intestinal Lactobacillus murinus -derived small RNAs target porcine polyamine metabolism

Proceedings of the National Academy of Sciences of the United States of America
Significance Polyamine metabolism participates in various processes of host physiology and disease. The roles of intrinsic factors in polyamine metabolism have been well clarified, but the effects of extrinsic factors, such as gut microbes, on polyamine ...
Yuan Liu, Bingnan Liu, Ren Wenkai
exaly   +2 more sources

Polyamine metabolism as a regulator of cellular and organismal aging [PDF]

Amino Acids
Polyamines - putrescine, spermidine, and spermine - are ubiquitous cationic molecules that are essential for cellular proliferation and homeostasis.
Takeshi Uemura, Jun Takayama, Akihiro Oguro, Yusuke Terui   +3 more
doaj   +2 more sources