Polyamine Metabolism and Anti-Tumor Immunity [PDF]
Frontiers in ImmunologyGrowing attention has been directed toward the critical role of polyamines in the tumor microenvironment and immune regulation. Polyamines, primarily comprising putrescine, spermidine, and spermine, are tightly regulated through coordinated biosynthesis,
Qi-Yue Chen
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Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages [PDF]
Smart MedicinePolyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma pathogenesis.
Hao-Zhen Ren, Dayu Chen, Guang Zhang
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Frontiers in Immunology, 2022 The study of metabolism provides important information for understanding the biological basis of cancer cells and the defects of cancer treatment. Disorders of polyamine metabolism is a common metabolic change in cancer.
Jincheng Zeng, Bihua Lin, Ziyu Ye
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Polyamine Metabolism in Brain Health and Disease [PDF]
Neuropharmacology and TherapyPolyamines, primarily spermidine and spermine, are small polycationic molecules essential for cell growth, signaling, and survival. Through electrostatic interactions with nucleic acids, lipids, and proteins, they regulate gene expression, organelle ...
Xianzun Tao +2 more
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Spatial Association Between Polyamine Metabolism and Lipid Peroxidation in Different Pathological Regions of Glioblastoma [PDF]
BiomedicinesBackground: Glioblastoma is highly heterogeneous, highly invasive, and resistant to temozolomide, with an extremely low 5-year survival rate. The spatial association between polyamine metabolism and ferroptosis remains unclear.
Zheng Qu +14 more
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Comprehensive analysis of the clinical and biological significances of polyamine metabolism in glioma [PDF]
Discover OncologyPolyamines, including spermidine, spermine, and putrescine, are polycationic alkylamines in mammalian cells. However, the prognostic impact of polyamine in glioma remains unclear.
Fei Bai +5 more
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Polyamine metabolism as a regulator of cellular and organismal aging [PDF]
Amino AcidsPolyamines - putrescine, spermidine, and spermine - are ubiquitous cationic molecules that are essential for cellular proliferation and homeostasis.
Takeshi Uemura +3 more
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Polyamine metabolism in cancer: drivers of immune evasion, ferroptosis and therapy resistance [PDF]
Expert Reviews in Molecular MedicinePolyamines putrescine, spermidine and spermine are small, positively charged metabolites indispensable for DNA stabilization, chromatin remodelling, RNA translation and redox balance, with dynamic distribution across the nucleus, mitochondria and ...
Sainavya Sree Chenna +2 more
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Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status [PDF]
Nature CommunicationsThe resistance to KRAS-targeted therapies, particularly due to co-occurring gene mutations, remains a significant challenge. Through a metabolite library screening, we reveal that polyamines sensitize KRAS inhibitors only in KRAS MU /KEAP1 WT cells but ...
Yunyi Bian +15 more
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Integrating single-cell RNA-seq and machine learning to dissect polyamine metabolism in metabolic dysfunction-associated steatotic liver disease [PDF]
Frontiers in MedicineBackgroundDysregulated immunometabolism is central to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Although polyamines contribute to cellular stress responses and immune-cell function, their cell-type-specific ...
Peng Zou, Lin Sun, Zhibin Lin
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