Results 41 to 50 of about 29,877 (250)

Antitumor potential of polyamines in cancer

Acta Biochimica et Biophysica Sinica
The dysregulation of polyamines in tumors has made polyamine metabolism an appealing target for cancer therapy. Gene mutations drive the reprogramming of polyamine metabolism in tumors, presenting promising opportunities for clinical treatment.
Liu He, Liu Yi, Wang Xinyue, Xiao Zhiwen, Ni Quanxing, Yu Xianjun, Luo Guopei   +6 more
doaj   +1 more source

Mammalian polyamine metabolism and function [PDF]

IUBMB Life, 2009
AbstractPolyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will
openaire   +2 more sources

Divergent polyamine metabolism in the Apicomplexa [PDF]

Microbiology, 2007
The lead enzymes of polyamine biosynthesis, i.e. ornithine decarboxylase (ODC) and arginine decarboxylase (ADC), were not detected in Toxoplasma gondii [the limit of detection for ODC and ADC was 5 pmol min(-1) (mg protein)(-1)], indicating that T. gondii lacks a forward-directed polyamine biosynthetic pathway, and is therefore a polyamine auxotroph ...
Tuesday, Cook, David, Roos, Mary, Morada, Guan, Zhu, Janet S, Keithly, Jean E, Feagin, Gang, Wu, Nigel, Yarlett   +7 more
openaire   +2 more sources

The expansive effects of polyamines on the metabolism and virulence of Streptococcus pneumoniae

Pneumonia, 2021
Polyamines are common intracellular metabolites of nearly all cells, and their conservation across a vast diversity of cells suggests critical roles for these compounds in cellular physiology.
Bindu Nanduri, Edwin Swiatlo
doaj   +1 more source

Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes

, 2018
Many biological processes result from the coupling of metabolic pathways. Considering this, proliferation depends on adequate iron and polyamines, and although iron-depletion impairs proliferation, the metabolic link between iron and polyamine metabolism
Patric J. Jansson, Bae, Dong-Hun, Lina Al-Akra, Casero, Robert A, Des R. Richardson, Aritee R. Siafakas, Yohan Suryo Rahmanto, Lane, Darius JR, Dong-Hun Bae, Al-Akra, Lina, Siafakas, Aritee R, Richardson, Des R, Robert A. Casero, Jansson, Patric J, Rahmanto, Yohan Suryo, Darius J.R. Lane   +15 more
core   +1 more source

Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases

Frontiers in Nutrition, 2019
The polyamines putrescine, spermidine, and spermine are widely distributed polycationic compounds essential for cellular functions. Intracellular polyamine pools are tightly regulated by a complex regulatory mechanism involving de novo biosynthesis ...
Bruno Ramos-Molina, Bruno Ramos-Molina, Maria Isabel Queipo-Ortuño, Maria Isabel Queipo-Ortuño, Ana Lambertos, Ana Lambertos, Francisco J. Tinahones, Francisco J. Tinahones, Rafael Peñafiel, Rafael Peñafiel   +9 more
doaj   +1 more source

Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV

Nature Communications, 2023
Polyamine metabolism is a determinant of T helper cell polarization. Here, Mahalingam et al analyse the metabolic and transcriptomic profile of oral mucosa from people living with HIV to demonstrate the effect of polyamine synthesis on T cell dysfunction
S. S. Mahalingam, S. Jayaraman, N. Bhaskaran, E. Schneider, F. Faddoul, A. Paes da Silva, M. M. Lederman, R. Asaad, K. Adkins-Travis, L. P. Shriver, P. Pandiyan   +10 more
doaj   +1 more source

Ultra‐High‐Throughput Discovery of Multifunctional Polyphenolic Coatings on Droplet Microarrays

Advanced Materials, EarlyView.
An ultra‐high‐throughput (UHT) combinatorial strategy enables the miniaturized synthesis and screening of ≈30 000 polyamine‐polyphenolic (PaPp) coatings using droplet microarrays (DMA). This approach reveals hundreds of previously unknown fluorescent, redox‐active, and antibacterial materials, including multifunctional, cell‐compatible surfaces ...
Vania Tanda Widyaya, Joaquín E. Urrutia Gómez, Paul Reuß, Alexander Welle, Rolf A. Gattung, Jana Mayer, Peter Krolla, Markus Reischl, Pascal Friederich, Anna A. Popova, Thomas Schwartz, Pavel A. Levkin   +11 more
wiley   +1 more source

Polyamine Metabolism in Brain Health and Disease

Neuropharmacology and Therapy
Polyamines, primarily spermidine and spermine, are small polycationic molecules essential for cell growth, signaling, and survival. Through electrostatic interactions with nucleic acids, lipids, and proteins, they regulate gene expression, organelle ...
Xianzun Tao, Tracey Nassuna, R. Grace Zhai   +2 more
doaj   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source