Results 21 to 30 of about 1,489,782 (254)

Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers

Medical Sciences, 2017
Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC).
Chelsea Massaro, Jenna Thomas, Otto Phanstiel   +2 more
doaj   +3 more sources

Antizyme Inhibitors in Polyamine Metabolism and Beyond: Physiopathological Implications

Medical Sciences, 2018
The intracellular levels of polyamines, cationic molecules involved in a myriad of cellular functions ranging from cellular growth, differentiation and apoptosis, is precisely regulated by antizymes and antizyme inhibitors via the modulation of the ...
Bruno Ramos-Molina, Ana Lambertos, Rafael Peñafiel   +2 more
doaj   +3 more sources

Alterations of renal polyamine metabolism in mice with folic acid-induced chronic kidney disease [PDF]

Biochemistry and Biophysics Reports
Chronic kidney disease (CKD) often follows acute kidney injury, leading to renal fibrosis and progressive renal failure. Spermine, a polyamine with antioxidant and anti-inflammatory properties, helps reduce renal fibrosis and may serve as a biomarker for
Cheng Xue, Jiaxin Chen, Xinming Li, Chenchen Zhou, Zhiguo Mao   +4 more
doaj   +2 more sources

A perspective of polyamine metabolism [PDF]

Biochemical Journal, 2003
Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both electrostatically and covalently and, as a consequence, have a variety of cellular effects. The complexity of polyamine metabolism and the multitude of compensatory mechanisms that are invoked to maintain polyamine homoeostasis argue ...
Heather M, Wallace, Alison V, Fraser, Alun, Hughes   +2 more
openaire   +2 more sources

Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.

Cancer Letters, 2023
A key mechanism driving colorectal cancer (CRC) development is the upregulation of MYC and its targets, including ornithine decarboxylase (ODC), a master regulator of polyamine metabolism.
S. Coni, Rosa Bordone, D. Ivy, Zuleyha Nihan Yurtsever, Laura Di Magno, Rodrigo D’Amico, Bianca Cesaro, A. Fatica, F. Belardinilli, Francesca Bufalieri, M. Maroder, E. De Smaele, L. Di Marcotullio, G. Giannini, E. Agostinelli, G. Canettieri   +15 more
semanticscholar   +1 more source

Investigation of The Roles of Hydrogen Peroxide and NADPH Oxidase in The Regulation of Polyamine Metabolism in Maize Plants under Drought Stress Conditions

Journal of Agricultural Sciences, 2022
The relationship between hydrogen peroxide and the metabolism of polyamines and the role of NADPH oxidase (NOX) in that relationship under drought conditions remains unclear.
Aykut Sağlam, Mehmet Demiralay, Fuat Yetişsin, Asım Kadıoğlu   +3 more
doaj   +1 more source

Polyamine metabolism and cancer [PDF]

Journal of Cellular and Molecular Medicine, 2003
AbstractPolyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are intricately controlled by biosynthetic and catabolic enzymes. The biosynthetic enzymes are ornithine decarboxylase, S‐adenosylmethionine decarboxylase, spermidine synthase, and spermine synthase.
Thresia, Thomas, T J, Thomas
openaire   +2 more sources

Polyamine metabolism patterns characterized tumor microenvironment, prognosis, and response to immunotherapy in colorectal cancer

Cancer Cell International, 2023
Background Changes in Polyamine metabolism (PAM) have been shown to establish a suppressive tumor microenvironment (TME) and substantially influence the progression of cancer in the recent studies.
E. Zhang, Chengsheng Ding, Shuchun Li, Batuer Aikemu, Xueliang Zhou, Xiaodong Fan, Jing Sun, X. Yang, Minhua Zheng   +8 more
semanticscholar   +1 more source

Influence of a phyA Mutation on Polyamine Metabolism in Arabidopsis Depends on Light Spectral Conditions

Plants, 2023
The aim of the study was to reveal the influence of phyA mutations on polyamine metabolism in Arabidopsis under different spectral compositions. Polyamine metabolism was also provoked with exogenous spermine.
Altafur Rahman, Judit Tajti, Imre Majláth, Tibor Janda, Sylva Prerostova, Mohamed Ahres, Magda Pál   +6 more
doaj   +1 more source

c-MYC-Driven Polyamine Metabolism in Ovarian Cancer: From Pathogenesis to Early Detection and Therapy

Cancers, 2023
Simple Summary This review informs on how the MYC signaling is dysregulated and participates in ovarian cancer progression, and the unmet challenge to directly target MYC for ovarian cancer treatment.
Yihui Chen, R. León-Letelier, Ali H Abdel Sater, J. Vykoukal, J. Dennison, S. Hanash, J. Fahrmann   +6 more
semanticscholar   +1 more source