Results 11 to 20 of about 973,687 (259)
Plants, 2023 The aim of the study was to reveal the influence of phyA mutations on polyamine metabolism in Arabidopsis under different spectral compositions. Polyamine metabolism was also provoked with exogenous spermine.
Altafur Rahman +6 more
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A perspective of polyamine metabolism [PDF]
Biochemical Journal, 2003 Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both electrostatically and covalently and, as a consequence, have a variety of cellular effects. The complexity of polyamine metabolism and the multitude of compensatory mechanisms that are invoked to maintain polyamine homoeostasis argue ...
Heather M, Wallace +2 more
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Polyamine metabolism and obesity: polyamine metabolic enzymes involved in obesity [PDF]
ACTA Pharmaceutica Sciencia, 2018 The natural polyamines, putrescine, spermidine and spermine are distributed widely in all cells including adipocytes. They are involved in several physiological processes involving gene expression and cell proliferation. The body pool of polyamines is maintained by endogenous biosynthesis, intestinal microorganisms and the diet.
Büyükuslu, Nihal +1 more
openaire +4 more sources
One-Carbon and Polyamine Metabolism as Cancer Therapy Targets
Biomolecules, 2022 Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid replication. A common target of this metabolic reprogramming is one-carbon metabolism which is notable for its function in DNA synthesis, protein and DNA ...
Anowarul Islam +3 more
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Polyamine Metabolism in Disease and Polyamine-Targeted Therapies [PDF]
, 2019 Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport.
Murray-Stewart, Tracy
core +5 more sources
Cancer InnovationBackground Polyamines play important roles in cell growth and proliferation. Polyamine metabolism genes are dysregulated in various tumors. Some polyamine metabolism genes are regulated by transcription factors.
Qi Song, Yixuan Wang, Sen Liu
doaj +2 more sources
Medical Sciences, 2022 Polyamines are small polycationic alkylamines involved in many fundamental cellular processes, including cell proliferation, survival, and protection from oxidative stress.
Cassandra E. Holbert +6 more
doaj +2 more sources
Polyamine metabolism changes in psoriasis
Indian Journal of Dermatology, 2013 Introduction: Polyamines - putrescine, spermidine and spermine are polycationic compounds ubiquitous for all living organisms. They are essential for the cell growth and differentiation, the control of cell cycle progress, apoptosis, and cancerogenesis ...
Valentina Broshtilova +2 more
doaj +3 more sources
Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function [PDF]
eLife, 2021 Microsatellite expansions of CCTG repeats in the cellular nucleic acid-binding protein (CNBP) gene leads to accumulation of toxic RNA and have been associated with myotonic dystrophy type 2 (DM2).
Sonia Coni +16 more
doaj +7 more sources
Heterogeneity in polyamine metabolism dictates prognosis and immune checkpoint blockade response in hepatocellular carcinoma [PDF]
Frontiers in ImmunologyImmune checkpoint blockade holds promise in hepatocellular carcinoma (HCC) treatment, but its efficacy remains limited. Dysregulated polyamine metabolism and its interaction with oncogenic pathways promote tumor progression. However, the heterogeneity of
Jianyan Pan +3 more
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