Polyamine metabolism and cancer: treatments, challenges and opportunities
Nature Reviews Cancer, 2018 Advances in our understanding of the metabolism and molecular functions of polyamines and their alterations in cancer have led to resurgence in the interest of targeting polyamine metabolism as an anticancer strategy.
Robert A Casero +2 more
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Polyamine metabolism in cancer: drivers of immune evasion, ferroptosis and therapy resistance [PDF]
Expert Reviews in Molecular MedicinePolyamines putrescine, spermidine and spermine are small, positively charged metabolites indispensable for DNA stabilization, chromatin remodelling, RNA translation and redox balance, with dynamic distribution across the nucleus, mitochondria and ...
Sainavya Sree Chenna +2 more
doaj +2 more sources
Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status [PDF]
Nature CommunicationsThe resistance to KRAS-targeted therapies, particularly due to co-occurring gene mutations, remains a significant challenge. Through a metabolite library screening, we reveal that polyamines sensitize KRAS inhibitors only in KRAS MU /KEAP1 WT cells but ...
Yunyi Bian +15 more
doaj +2 more sources
Polyamine metabolism changes in psoriasis
Indian Journal of Dermatology, 2013 Introduction: Polyamines - putrescine, spermidine and spermine are polycationic compounds ubiquitous for all living organisms. They are essential for the cell growth and differentiation, the control of cell cycle progress, apoptosis, and cancerogenesis ...
Valentina Broshtilova +2 more
doaj +3 more sources
Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function
eLife, 2021 Microsatellite expansions of CCTG repeats in the cellular nucleic acid-binding protein (CNBP) gene leads to accumulation of toxic RNA and have been associated with myotonic dystrophy type 2 (DM2).
Sonia Coni +16 more
doaj +2 more sources
Polyamine metabolism in prostate cancer. [PDF]
Curr Opin OncolPurpose of review Normal and malignant prostate engage in high rates of de novo polyamine synthesis. This review considers how polyamine metabolism regulates prostate cancer initiation and progression. Recent findings The androgen receptor (AR) establishes a metabolic program to ...
Sena LA.
europepmc +3 more sources
Heterogeneity in polyamine metabolism dictates prognosis and immune checkpoint blockade response in hepatocellular carcinoma [PDF]
Frontiers in ImmunologyImmune checkpoint blockade holds promise in hepatocellular carcinoma (HCC) treatment, but its efficacy remains limited. Dysregulated polyamine metabolism and its interaction with oncogenic pathways promote tumor progression. However, the heterogeneity of
Jianyan Pan +3 more
doaj +2 more sources
Integrating single-cell RNA-seq and machine learning to dissect polyamine metabolism in metabolic dysfunction-associated steatotic liver disease [PDF]
Frontiers in MedicineBackgroundDysregulated immunometabolism is central to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Although polyamines contribute to cellular stress responses and immune-cell function, their cell-type-specific ...
Peng Zou, Lin Sun, Zhibin Lin
doaj +2 more sources
Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics [PDF]
Frontiers in ImmunologyBackgroundAccumulating evidence indicates that elevated polyamine levels are closely linked to tumor initiation and progression. However, the precise role of polyamine metabolism in hepatocellular carcinoma (HCC) remains poorly understood.MethodsWe ...
Yuexi Yu +6 more
doaj +2 more sources
The role of polyamine metabolism in cellular function and physiology.
Am J Physiol Cell PhysiolPolyamines are molecules with multiple amino groups that are essential for cellular function. The major polyamines are putrescine, spermidine, spermine, and cadaverine.
Schibalski RS +4 more
europepmc +2 more sources