Comprehensive analysis of the clinical and biological significances of polyamine metabolism in glioma [PDF]
Discover OncologyPolyamines, including spermidine, spermine, and putrescine, are polycationic alkylamines in mammalian cells. However, the prognostic impact of polyamine in glioma remains unclear.
Fei Bai +5 more
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A perspective of polyamine metabolism [PDF]
Biochemical Journal, 2003 Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both electrostatically and covalently and, as a consequence, have a variety of cellular effects.
Fraser, Alison V +2 more
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Polyamine metabolism as a regulator of cellular and organismal aging [PDF]
Amino AcidsPolyamines - putrescine, spermidine, and spermine - are ubiquitous cationic molecules that are essential for cellular proliferation and homeostasis.
Takeshi Uemura +3 more
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Polyamine metabolism in cancer: drivers of immune evasion, ferroptosis and therapy resistance [PDF]
Expert Reviews in Molecular MedicinePolyamines putrescine, spermidine and spermine are small, positively charged metabolites indispensable for DNA stabilization, chromatin remodelling, RNA translation and redox balance, with dynamic distribution across the nucleus, mitochondria and ...
Sainavya Sree Chenna +2 more
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International Journal of Molecular Sciences, 2022 Naturally occurring polyamines are absolutely required for cellular growth and proliferation. Many neoplastic cells are reliant on elevated polyamine levels and maintain these levels through dysregulated polyamine metabolism.
Cassandra E Holbert +2 more
exaly +2 more sources
Polyamine Metabolism in Disease and Polyamine-Targeted Therapies [PDF]
, 2019 Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis ...
Murray-Stewart, Tracy
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Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status [PDF]
Nature CommunicationsThe resistance to KRAS-targeted therapies, particularly due to co-occurring gene mutations, remains a significant challenge. Through a metabolite library screening, we reveal that polyamines sensitize KRAS inhibitors only in KRAS MU /KEAP1 WT cells but ...
Yunyi Bian +15 more
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Integrating single-cell RNA-seq and machine learning to dissect polyamine metabolism in metabolic dysfunction-associated steatotic liver disease [PDF]
Frontiers in MedicineBackgroundDysregulated immunometabolism is central to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Although polyamines contribute to cellular stress responses and immune-cell function, their cell-type-specific ...
Peng Zou, Lin Sun, Zhibin Lin
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MetabolitesBackground: The early nutritional metabolism of piglets is intimately associated with the regulation of immune function, and amino acids play a crucial role in modulating the fate and function of porcine immune cells, especially macrophages. However, the
Meimei Zhang +3 more
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Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics [PDF]
Frontiers in ImmunologyBackgroundAccumulating evidence indicates that elevated polyamine levels are closely linked to tumor initiation and progression. However, the precise role of polyamine metabolism in hepatocellular carcinoma (HCC) remains poorly understood.MethodsWe ...
Yuexi Yu +6 more
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