Results 31 to 40 of about 1,489,782 (254)
Polyamine metabolism is a central determinant of helper T cell lineage fidelity
Cell, 2021 Summary Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but the biological implications of this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing the ability
Daniel J. Puleston +25 more
semanticscholar +1 more source
Polyamine metabolism and obesity: polyamine metabolic enzymes involved in obesity [PDF]
ACTA Pharmaceutica Sciencia, 2018 The natural polyamines, putrescine, spermidine and spermine are distributed widely in all cells including adipocytes. They are involved in several physiological processes involving gene expression and cell proliferation. The body pool of polyamines is maintained by endogenous biosynthesis, intestinal microorganisms and the diet.
Büyükuslu, Nihal +1 more
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Microbiology Research, 2022 The mechanisms underlie increased stress tolerance in plants of salinity stress in plants by arbuscular mycorrhizal fungi (AMF) are poorly understood, particularly the role of polyamine metabolism.
A. El-Sawah +9 more
semanticscholar +1 more source
Stress and polyamine metabolism in fungi [PDF]
Frontiers in Chemistry, 2014 Fungi, as well as the rest of living organisms must deal with environmental challenges such as stressful stimuli. Fungi are excellent models to study the general mechanisms of the response to stress, because of their simple, but conserved, signal-transduction and metabolic pathways that are often equivalent to those present in other eukaryotic systems.
Valdés-Santiago, Laura +1 more
openaire +3 more sources
Polyamine metabolism and transport in gut microbes.
Bioscience, biotechnology and biochemistry, 2022 Polyamines (putrescine, spermidine, and spermine) are compounds with amino groups at both ends of a hydrocarbon. Polyamines produced by intestinal bacteria suppress chronic inflammation and enhance the intestinal barrier in the colon, and are also ...
Shin Kurihara
semanticscholar +1 more source
Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity
Cells, 2022 Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent work has highlighted that polyamines exert profound roles on the mammalian immune system, particularly inflammation and cancer. The mechanisms by which they control
Tzu-yi Chia, Andrew Zolp, Jason Miska
doaj +1 more source
Nature Communications, 2021 Intestinal microbiota-derived metabolites have biological importance for the host. Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota and regulate multiple biological processes.
A. Nakamura +14 more
semanticscholar +1 more source
LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages
Nature, 2022 The mammalian immune system uses various pattern recognition receptors to recognize invaders and host damage and transmits this information to downstream immunometabolic signalling outcomes. Laccase domain-containing 1 (LACC1) protein is an enzyme highly
Zheng Wei +3 more
semanticscholar +1 more source
Polyamines and related signaling pathways in cancer
Cancer Cell International, 2020 Polyamines are aliphatic compounds with more than two amino groups that play various important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs, and regulatory mechanisms of polyamine.
Jiajing Li +3 more
doaj +1 more source
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses
Proceedings of the National Academy of Sciences of the United States of America, 2016 Bo Chu, , Wei Gu
exaly +2 more sources