Results 31 to 40 of about 973,687 (259)

Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity

Cells, 2022
Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent work has highlighted that polyamines exert profound roles on the mammalian immune system, particularly inflammation and cancer. The mechanisms by which they control
Tzu-yi Chia, Andrew Zolp, Jason Miska
doaj   +1 more source

Polyamine metabolism is a central determinant of helper T cell lineage fidelity [PDF]

, 2021
Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but the biological implications of this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing the ability of CD4+
Pearce, Edward J., Pearce, Erika L., Puleston, Daniel J.   +2 more
core   +2 more sources

Mathematical modelling of polyamine metabolism in bloodstream-form trypanosoma brucei: An application to drug target identification [PDF]

, 2013
© 2013 Gu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Desmond J Higham, Xu Gu (276054), Gilbert, D, Gu, X, David Reid (276055), Desmond J. Higham (261142), Reid, D, David Gilbert, David Reid, Gilbert David, Gu Xu, David Gilbert (276056), Reid David, Desmond J. Higham, Xu Gu, Higham, DJ, Higham Desmond J.   +16 more
core   +2 more sources

Polyamines and related signaling pathways in cancer

Cancer Cell International, 2020
Polyamines are aliphatic compounds with more than two amino groups that play various important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs, and regulatory mechanisms of polyamine.
Jiajing Li, Yan Meng, Xiaolin Wu, Yuxin Sun   +3 more
doaj   +1 more source

Polyamines and Their Metabolism: From the Maintenance of Physiological Homeostasis to the Mediation of Disease

Medical Sciences, 2022
The polyamines spermidine and spermine are positively charged aliphatic molecules. They are critical in the regulation of nucleic acid and protein structures, protein synthesis, protein and nucleic acid interactions, oxidative balance, and cell ...
Kamyar Zahedi, Sharon Barone, Manoocher Soleimani   +2 more
doaj   +1 more source

Mycolicibacterium smegmatis possesses operational agmatinase but contains no detectable polyamines

International Journal of Mycobacteriology, 2020
Background: Polyamines are widespread intracellular molecules able to influence antibiotic susceptibility, but almost nothing is known on their occurrence and physiological role in mycobacteria.
Mikhail Zamakhaev, Ivan Tsyganov, Larisa Nesterova, Anna Akhova, Artem Grigorov, Julia Bespyatykh, Tatyana Azhikina, Alexander Tkachenko, Mikhail Shumkov   +8 more
doaj   +1 more source

Polyamine-Based Pt(IV) Prodrugs as Substrates for Polyamine Transporters Preferentially Accumulate in Cancer Metastases as DNA and Polyamine Metabolism Dual-Targeted Antimetastatic Agents

, 2019
Diverse platinum drug candidates have been designed to improve inhibitory potency and overcome resistance for orthotopic tumors. However, the antimetastatic properties have rarely been reported.
Sitong Liu (3750979), Shudi Guo (8118854), Yingguang Li, Peng George Wang (256049), Hanfang Liu (5775875), Jing Ma, Kexin Yue (8118851), Peng George Wang, Xiao Zhang (152326), Songqiang Xie, Yingguang Li (5775884), Zhuoqing Xi (5775878), Xiao Zhang, Kai Feng, Songqiang Xie (1750744), Kai Feng (502124), Jianing Liu, Chaojie Wang (2175530), Chaojie Wang, Zhuoqing Xi, Sitong Liu, Jing Ma (24574), Qi Ma (141685), Hanfang Liu, Kexin Yue, Linrong Li, Qi Ma, Shudi Guo, Linrong Li (7464398), Jianing Liu (140090)   +29 more
core   +2 more sources

Polyamine metabolism in prostate cancer. [PDF]

Curr Opin Oncol
Purpose of review Normal and malignant prostate engage in high rates of de novo polyamine synthesis. This review considers how polyamine metabolism regulates prostate cancer initiation and progression. Recent findings The androgen receptor (AR) establishes a metabolic program to ...
Sena LA.
europepmc   +4 more sources

Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition [PDF]

, 2014
Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms.
Didac Carmona-Gutierrez, Carmona-Gutierrez Didac, Terry K Smith, Rockenfeller Patrick, Minois Nadège, Smith Terry K., Terry K. Smith (112550), Patrick Rockenfeller, Rockenfeller, Patrick, Smith, Terry K, Nadège Minois, Carmona-Gutierrez, Didac, Patrick Rockenfeller (596007), Didac Carmona-Gutierrez (374288), Minois, Nadège, Nadège Minois (596006), Smith, Terry K; id_orcid   +16 more
core   +1 more source

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.

PLoS ONE, 2017
Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers.
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero   +6 more
doaj   +1 more source