Results 51 to 60 of about 1,489,782 (254)

Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.

Journal of Clinical Investigation, 2021
Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral impairments; however, mechanisms promoting tau pathology and how tau elicits behavioral impairment remain unclear.
Leslie A. Sandusky-Beltran, A. Kovalenko, Devon S. Placides, Kevin Ratnasamy, Chao Ma, Jerry B. Hunt, Huimin Liang, J. Calahatian, Camilla Michalski, M. Fahnestock, Laura J. Blair, April L Darling, Jeremy D. Baker, Sarah N. Fontaine, C. Dickey, J. Gamsby, K. Nash, E. Abner, M. Selenica, Daniel C. Lee   +19 more
semanticscholar   +1 more source

Polyamine Metabolism under Different Light Regimes in Wheat

International Journal of Molecular Sciences, 2021
Although the relationship between polyamines and photosynthesis has been investigated at several levels, the main aim of this experiment was to test light-intensity-dependent influence of polyamine metabolism with or without exogenous polyamines.
O. K. Gondor, J. Tajti, K. Hamow, I. Majláth, G. Szalai, T. Janda, Magda Pál   +6 more
semanticscholar   +1 more source

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.

PLoS ONE, 2017
Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers.
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero   +6 more
doaj   +1 more source

Antitumor potential of polyamines in cancer

Acta Biochimica et Biophysica Sinica
The dysregulation of polyamines in tumors has made polyamine metabolism an appealing target for cancer therapy. Gene mutations drive the reprogramming of polyamine metabolism in tumors, presenting promising opportunities for clinical treatment.
Liu He, Liu Yi, Wang Xinyue, Xiao Zhiwen, Ni Quanxing, Yu Xianjun, Luo Guopei   +6 more
doaj   +1 more source

Involvement of Polyamine Metabolism in the Response of Medicago truncatula Genotypes to Salt Stress

Plants, 2021
Salinity constitutes one of the most important causes leading to severe reduction in plant yield. Several reports correlate the accumulation of polyamines in plants with tolerance to abiotic stress cues.
C. Antoniou, Xavier Zarza, Gholamreza Gohari, Sima Panahirad, Panagiota S. Filippou, A. Tiburcio, V. Fotopoulos   +6 more
semanticscholar   +1 more source

Beyond the Fixed Charge: A New On‐Tissue Derivatisation Strategy Employing Photoionisable Chromophores for Mass Spectrometry Imaging of Amino‐Containing Metabolites

Angewandte Chemie, EarlyView.
We introduce a novel chemical derivatisation strategy for the UV‐activated detection of elusive metabolites. Incorporation of a tocopherol‐active chromophore allows for the detection of tagged analytes as photoionised radical cations, selectively induced by a 266 nm laser.
Sofia R. McGowan, Andrew J. Tague, Ashna A. Kumar, Marie Ranson, Christopher J. T. Hyland, Shane R. Ellis   +5 more
wiley   +2 more sources

Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis

Nature Cell Biology
The ability of tumour cells to thrive in harsh microenvironments depends on the utilization of nutrients available in the milieu. Here we show that pancreatic cancer-associated fibroblasts (CAFs) regulate tumour cell metabolism through the secretion of ...
Divya Murthy, K. S. Attri, S. Shukla, Ravi Thakur, Nina V. Chaika, Chunbo He, Dezhen Wang, Kanupriya Jha, Aneesha Dasgupta, Ryan J. King, S. E. Mulder, J. Souchek, T. Gebregiworgis, Vikant Rai, Rohit Patel, T. Hu, Sandeep Rana, S. Kollala, Camila G Pacheco, P. Grandgenett, Fang Yu, Vikas Kumar, Audrey J. Lazenby, Adrian R. Black, Susanna V Ulahannan, Ajay Jain, B. Edil, D. Klinkebiel, Robert Powers, A. Natarajan, Michael A. Hollingsworth, Kamiya Mehla, Quan P. Ly, Sarika Chaudhary, Rosa F. Hwang, K. Wellen, Pankaj K. Singh   +36 more
semanticscholar   +1 more source

Mammalian polyamine metabolism and function [PDF]

IUBMB Life, 2009
AbstractPolyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will
openaire   +2 more sources

Divergent polyamine metabolism in the Apicomplexa [PDF]

Microbiology, 2007
The lead enzymes of polyamine biosynthesis, i.e. ornithine decarboxylase (ODC) and arginine decarboxylase (ADC), were not detected in Toxoplasma gondii [the limit of detection for ODC and ADC was 5 pmol min(-1) (mg protein)(-1)], indicating that T. gondii lacks a forward-directed polyamine biosynthetic pathway, and is therefore a polyamine auxotroph ...
Tuesday, Cook, David, Roos, Mary, Morada, Guan, Zhu, Janet S, Keithly, Jean E, Feagin, Gang, Wu, Nigel, Yarlett   +7 more
openaire   +2 more sources

The MUC1–HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling

Proceedings of the National Academy of Sciences of the United States of America
Significance Pancreatic cancer is a devastating disease with limited treatment options and poor prognosis. This study uncovers a link between MUC1/hypoxia-inducible factor-1α (HIF-1α) signaling and polyamine metabolism.
Divya Murthy, K. S. Attri, Voddu Suresh, G. Rajacharya, C. Valenzuela, Ravi Thakur, Junzhang Zhao, S. Shukla, Nina V. Chaika, Drew A Labreck, C. Rao, Michael A. Hollingsworth, Kamiya Mehla, Pankaj K. Singh   +13 more
semanticscholar   +1 more source