Results 71 to 80 of about 29,877 (250)

An overview of polyamine metabolism in pancreatic ductal adenocarcinoma

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest major cancers, with a five year survival rate of less than 8%. With current therapies only giving rise to modest life extension, new approaches are desperately needed.
Otto Phanstiel, Phanstiel, Otto
core   +1 more source

Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues

, 2021
Structurally complex and diverse polyamines and polyamine analogues are potential therapeutics and agrochemicals that can address grand societal challenges, for example, healthy ageing and sustainable food production. However, their structural complexity
Kristensen, M.,, Kristensen, Mette, Keasling, J.D.,, Keasling, J.D., Keasling, Jay D., Nielsen, Jens B, Jensen, Michael Krogh, Chen, Yu,, Krivoruchko, Anastasia, Chen, Yu, Özdemir, Emre,, Nielsen, Jens, Qin, Jiufu,, Krivoruchko, Anastasia,, Ji, Boyang,, Kristensen, M., 6zdemir, Emre, Qin, Jiufu, Ji, Boyang, Jensen, M. K., Nielsen, Jens B,, Özdemir, Emre, Jensen, M. K.,   +22 more
core   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Polyamines mediate cellular energetics and lipid metabolism through mitochondrial respiration to facilitate virus replication.

PLoS Pathogens
Polyamines are critical cellular components that regulate a variety of processes, including translation, cell cycling, and nucleic acid metabolism. The polyamines, putrescine, spermidine, and spermine, are found abundantly within cells and are positively-
Yazmin E Cruz-Pulido, Natalie J LoMascolo, Delaina May, Jomana Hatahet, Caroline E Thomas, Andrea K W Chu, Samantha P Stacey, Maria Del Mar Villanueva Guzman, Gregory Aubert, Bryan C Mounce   +9 more
doaj   +1 more source

Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma

Cells, 2019
Hedgehog (Hh) signaling is a critical developmental regulator and its aberrant activation, due to somatic or germline mutations of genes encoding pathway components, causes Basal Cell Carcinoma (BCC) and medulloblastoma (MB).
Sonia Coni, Laura Di Magno, Silvia Maria Serrao, Yuta Kanamori, Enzo Agostinelli, Gianluca Canettieri   +5 more
doaj   +1 more source

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Polyamine Metabolism in Potassium-Deficient Bacteria [PDF]

Journal of Bacteriology, 1972
The metabolism of polyamines was studied in K + -dependent strains of Escherichia coli . When these stringent organisms were in a medium containing Na + instead of K + , protein synthesis was arrested, but synthesis of ribonucleic acid continued
K E, Rubenstein, E, Streibel, S, Massey, L, Lapi, S S, Cohen   +4 more
openaire   +2 more sources

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle [PDF]

Hepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting antivirals were introduced into clinical practice.
Lea Monnier, Smirnova, Olga A, Yanvarev, Dmitry V, Rindlisbacher, Barbara, Olga N. Ivanova, Khomutov, Alex R, Duponchel, Sarah, Olga A. Smirnova, Valuev-Elliston, Vladimir T, Inna L. Karpenko, Molle, Jennifer, Cedric Bovet, Jennifer Molle, Sergey N. Kochetkov, Olga A. Khomich, Alex R. Khomutov, Dmitry V. Yanvarev, Barbara Rindlisbacher, Vladimir T. Valuev-Elliston, Monnier, Lea, Karpenko, Inna L, Boyan Grigorov, Mikhail V. Golikov, Alexander V. Ivanov, Birke Bartosch, Bartosch, Birke, Zakirova, Natalia F, Golikov, Mikhail V, Bovet, Cedric, Ivanov, Alexander V, Sarah Duponchel, Natalia F. Zakirova, Kochetkov, Sergey N, Khomich, Olga A, Ivanova, Olga N, Grigorov, Boyan   +35 more
core   +1 more source