Results 91 to 100 of about 973,687 (259)

c-MYC-Driven Polyamine Metabolism in Ovarian Cancer: From Pathogenesis to Early Detection and Therapy

, 2023
c-MYC and its paralogues MYCN and MYCL are among the most frequently amplified and/or overexpressed oncoproteins in ovarian cancer. c-MYC plays a key role in promoting ovarian cancer initiation and progression. The polyamine pathway is a bona fide target
Samir Hanash, Ali Hussein Abdel Sater, Johannes F. Fahrmann, Ricardo A. León-Letelier, Jennifer B. Dennison, Yihui Chen, Jody Vykoukal, Vykoukal, Jody, León-Letelier, Ricardo A., Dennison, Jennifer B., Hanash, Samir, Abdel Sater, Ali Hussein, Chen, Yihui, Fahrmann, Johannes F.   +13 more
core   +1 more source

Amino Acid and Biogenic Amine Profiles in Sausages Reformulated With Processed, Fermented Oyster Mushrooms

ChemFoodChem, EarlyView.
This research showed that sausage reformulation preserves high essential amino acid and branched‐chain amino acid content, as well as increasing free amino acids (FAA) related to umami flavor and health‐promoting components such as GABA in the products.
Albert Gashi, György Kenesei, Meltem Boylu Kovács, Zsuzsanna Mednyánszky, Livia Simon Sarkadi   +4 more
wiley   +1 more source

The Synergistic Benefit of Combination Strategies Targeting Tumor Cell Polyamine Homeostasis

Mammalian polyamines, including putrescine, spermidine, and spermine, are positively charged amines that are essential for all living cells including neoplastic cells.
Ting-Ann Liu, Liu, Ting-Ann, Casero, Robert A., Stewart, Tracy Murray, Tracy Murray Stewart, Robert A. Casero   +5 more
core   +1 more source

The Impact of Glycation on Protein Digestibility

ChemFoodChem, EarlyView.
Schematic overview of how protein glycation affects digestibility and downstream nutritional consequences. Glycation‐derived structural modifications reduce protease accessibility, leading to limited hydrolysis and altered peptide generation. These changes decrease amino acid bioavailability and may subsequently contribute to microbiome alterations ...
Lea Hönemann, Simone Lipinski, Jana Raupbach   +2 more
wiley   +1 more source

Integrative analysis of polyamine-associated genes reveals a prognostic and immunological signature in esophageal squamous cell carcinoma

Discover Oncology
Esophageal squamous cell carcinoma (ESCA) is a highly aggressive malignancy with substantial heterogeneity and poor prognosis. Polyamine metabolism has been implicated in tumor progression and immune regulation, yet its specific role in ESCA remains ...
Xiuli Cao, Yuanyuan Chen, Tao Li, Jinxing Wei   +3 more
doaj   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Polyamines: the pivotal amines in influencing the tumor microenvironment

Discover Oncology
Cellular proliferation, function and survival is reliant upon maintaining appropriate intracellular polyamine levels. Due to increased metabolic needs, cancer cells elevate their polyamine pools through coordinated metabolism and uptake.
Cassandra E. Holbert, Robert A. Casero, Tracy Murray Stewart   +2 more
doaj   +1 more source

Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle [PDF]

Hepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting antivirals were introduced into clinical practice.
Lea Monnier, Smirnova, Olga A, Yanvarev, Dmitry V, Rindlisbacher, Barbara, Olga N. Ivanova, Khomutov, Alex R, Duponchel, Sarah, Olga A. Smirnova, Valuev-Elliston, Vladimir T, Inna L. Karpenko, Molle, Jennifer, Cedric Bovet, Jennifer Molle, Sergey N. Kochetkov, Olga A. Khomich, Alex R. Khomutov, Dmitry V. Yanvarev, Barbara Rindlisbacher, Vladimir T. Valuev-Elliston, Monnier, Lea, Karpenko, Inna L, Boyan Grigorov, Mikhail V. Golikov, Alexander V. Ivanov, Birke Bartosch, Bartosch, Birke, Zakirova, Natalia F, Golikov, Mikhail V, Bovet, Cedric, Ivanov, Alexander V, Sarah Duponchel, Natalia F. Zakirova, Kochetkov, Sergey N, Khomich, Olga A, Ivanova, Olga N, Grigorov, Boyan   +35 more
core   +2 more sources

Autonomous Nanomedicine: Closing the Biological Validation Gap

Exploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source