Results 91 to 100 of about 29,877 (250)

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source

Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism [PDF]

, 2019
Both single and multicellular organisms depend on anti-stress mechanisms that enable them to deal with sudden changes in the environment, including exposure to heat and oxidants.
Mohammad Tauqeer Alam, Haas, Robert, Oscar Méndez-Lucio, Robert Haas, David Alejandro Peña Navarro, Olin-Sandoval, Viridiana, Segal, Joanna, Clara Correia-Melo, Leonor Miller-Fleming, Jakob Vowinckel, Lucia Herrera-Dominguez, Miller-Fleming, Leonor, Correia-Melo, Clara, Mülleder, Michael, Markus Ralser, Joanna Segal, Méndez-Lucio, Oscar, Kamrad, Stephan, Herrera-Dominguez, Lucia, Stephan Kamrad, Yu, Jason Shu Lim, Michael Mülleder, Jason Shu Lim Yu, Alam, Mohammad T., Peña Navarro, David Alejandro, Viridiana Olin-Sandoval, Vowinckel, Jakob, Ralser, Markus   +27 more
core   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Integrative analysis of polyamine-associated genes reveals a prognostic and immunological signature in esophageal squamous cell carcinoma

Discover Oncology
Esophageal squamous cell carcinoma (ESCA) is a highly aggressive malignancy with substantial heterogeneity and poor prognosis. Polyamine metabolism has been implicated in tumor progression and immune regulation, yet its specific role in ESCA remains ...
Xiuli Cao, Yuanyuan Chen, Tao Li, Jinxing Wei   +3 more
doaj   +1 more source

Polyamine Metabolism in Flax in Response to Treatment with Pathogenic and Non-pathogenic Fusarium Strains

Frontiers in Plant Science, 2015
Flax crop yield is limited by various environmental factors, but the largest crop losses worldwide are caused by Fusarium infection. Polyamines are one of the many metabolites possibly involved in the plant response to infection.
Wioleta eWojtasik, Anna eKulma, Katarzyna eNamysł, Marta ePreisner, Jan eSzopa   +4 more
doaj   +1 more source

Physicochemical Quality and Chemical Safety of Commercial Wet Cat Food: Composition, Oxidation, Biogenic Amines, and Trace Elements

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study investigated the physicochemical characteristics and chemical safety of commercial wet cat foods marketed in Brazil. Twenty products labeled as beef, chicken and fish flavors were analyzed for proximate composition, pH, lipid and protein oxidation, biogenic amines, and essential and potentially toxic trace elements.
Marina Teixeira de Vries Mársico, Eliane Teixeira Mársico, Celso Fasura Balthazar, João Paulo de Sá Felizardo, Roberto Meigikos dos Anjos, Erick Almeida Esmerino, Sérgio Borges Mano   +6 more
wiley   +1 more source

Comparative analysis of polyamine metabolism in wheat and maize plants [PDF]

, 2017
In the present work changes in polyamine contents were investigated after various hydroponic polyamine treatments (putrescine, spermidine and spermine at 0.1, 0.3 and 0.5 mM concentrations) in two different crop species, wheat and maize.
Peeva, Violeta, Janda, Tibor, Szalai, Gabriella, Janda, Katalin, Darkó, Éva, Pál, Magda   +5 more
core   +1 more source

Polyamine metabolism is a central determinant of helper T cell lineage fidelity

, 2021
Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but the biological implications of this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing the ability of CD4+
Pearce, Edward J., Pearce, Erika L., Puleston, Daniel J.   +2 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Polyamines: the pivotal amines in influencing the tumor microenvironment

Discover Oncology
Cellular proliferation, function and survival is reliant upon maintaining appropriate intracellular polyamine levels. Due to increased metabolic needs, cancer cells elevate their polyamine pools through coordinated metabolism and uptake.
Cassandra E. Holbert, Robert A. Casero, Tracy Murray Stewart   +2 more
doaj   +1 more source