Results 81 to 90 of about 973,687 (259)

Beyond Protein Synthesis: The Multifunctional Role of Functional Amino Acids in Modulating Meat Quality in Ruminants

Animal Research and One Health, EarlyView.
Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu, Tian Xia, Xiaokang Lv, Man Ren, Chuanshe Zhou, Zhiliang Tan   +5 more
wiley   +1 more source

Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias

Cell Death Discovery
Polyamines, namely putrescine, spermidine and spermine, are involved in multiple molecular pathways through their ability to bind nucleic acids and modulate protein stability.
Francesca Pirini, Anna Ferrari, Mouna Jandoubi, Irene Azzali, Davide Angeli, Rossana Mondrone, Chiara Bracci, Francesca Ruggieri, Giovanni Martinelli, Giorgia Simonetti   +9 more
doaj   +1 more source

Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues

, 2021
Structurally complex and diverse polyamines and polyamine analogues are potential therapeutics and agrochemicals that can address grand societal challenges, for example, healthy ageing and sustainable food production. However, their structural complexity
Kristensen, M.,, Kristensen, Mette, Keasling, J.D.,, Keasling, J.D., Keasling, Jay D., Nielsen, Jens B, Jensen, Michael Krogh, Chen, Yu,, Krivoruchko, Anastasia, Chen, Yu, Özdemir, Emre,, Nielsen, Jens, Qin, Jiufu,, Krivoruchko, Anastasia,, Ji, Boyang,, Kristensen, M., 6zdemir, Emre, Qin, Jiufu, Ji, Boyang, Jensen, M. K., Nielsen, Jens B,, Özdemir, Emre, Jensen, M. K.,, Jens Nielsen, Yu Chen, Jay D. Keasling, Michael Krogh Jensen, Boyang Ji, Mette Kristensen, Emre Özdemir, Anastasia Krivoruchko, Jiufu Qin   +31 more
core   +1 more source

Hyperbranched poly‐L‐lysine surface‐engineered bioprosthetic heart valves with anti‐calcification, anti‐infection, and durability

BMEMat, EarlyView.
The challenges of bioprosthetic heart valves (BHV) with respect to calcification, infection, and poor durability are tackled by surface engineering of hyperbranched poly‐L‐lysine (HBPL), providing a translational solution to improve long‐term valve performance.
Pai Peng, Dongchao Qiu, Yongyuan Kang, Qiaoxuan Wang, Xuelong Wang, Boyana Parvanova, Miroslav Karabaliev, Changyou Gao   +7 more
wiley   +1 more source

Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum [PDF]

, 2010
Inhibition of polyamine biosynthesis and/or the perturbation of polyamine functionality have been exploited with success against parasitic diseases such as Trypanosoma infections.
Williams, Marni, Reeksting, S.B. (Shaun Bernard), Birkholtz, Lyn-Marie, Smit, Salome, Niemand, Jandeli, Louw, Abraham Izak, Van Brummelen, A.C. (Anna Catharina), Clark, Katherine   +7 more
core   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism [PDF]

, 2019
Both single and multicellular organisms depend on anti-stress mechanisms that enable them to deal with sudden changes in the environment, including exposure to heat and oxidants.
Mohammad Tauqeer Alam, Haas, Robert, Oscar Méndez-Lucio, Robert Haas, David Alejandro Peña Navarro, Olin-Sandoval, Viridiana, Segal, Joanna, Clara Correia-Melo, Leonor Miller-Fleming, Jakob Vowinckel, Lucia Herrera-Dominguez, Miller-Fleming, Leonor, Correia-Melo, Clara, Mülleder, Michael, Markus Ralser, Joanna Segal, Méndez-Lucio, Oscar, Kamrad, Stephan, Herrera-Dominguez, Lucia, Stephan Kamrad, Yu, Jason Shu Lim, Michael Mülleder, Jason Shu Lim Yu, Alam, Mohammad T., Peña Navarro, David Alejandro, Viridiana Olin-Sandoval, Vowinckel, Jakob, Ralser, Markus   +27 more
core   +1 more source

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

Distinct polyamine effects on Candida albicans morphogenesis identify spermidine as a key regulator

Microbiology Spectrum
Polyamines play essential and multifaceted roles in all organisms. However, their unique functions in fungal cell differentiation provide an opportunity to identify novel antifungal targets, as inhibition of essential metabolic pathways represents a ...
Ruvini U. Pathirana, Minelly I. Camargo, Geysira G. Vela, David Kadosh   +3 more
doaj   +1 more source

Peroxisome proliferator-activated receptor gamma and spermidine/spermine N¹-acetyltransferase gene expressions are significantly correlated in human colorectal cancer

BMC Cancer, 2006
Background The peroxisome proliferator-activated receptor γ (PPARγ) is a transcription factor that regulates adipogenic differentiation and glucose homeostasis.
Cavallini Aldo, Notarnicola Maria, Giannini Romina, Linsalata Michele   +3 more
doaj   +1 more source