Results 101 to 110 of about 29,877 (250)

Polyamine Drug Discovery

, 2011
Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection.

core   +1 more source

Omics Analyses Reveal a Potential Link between Hormone-Sensitive Lipase and Polyamine Metabolism

, 2009
Hormone-sensitive lipase (HSL), a key enzyme in fatty acid mobilization from lipid stores, is expressed in the liver and decreased hepatic insulin sensitivity has been reported in our HSL null mouse model.
Krogh, Morten,, Holm, Cecilia,, Fernandez, Céline, James, Peter,, Oredsson, Stina,, Persson, Lo,, Alm, Kersti,, Lund University., Wårell, Kristofer,   +8 more
core   +2 more sources

Age-related alteration of arginase activity impacts on severity of leishmaniasis. [PDF]

, 2008
BACKGROUND: The leishmaniases are a group of vector-borne parasitic diseases that represent a major international public health problem; they belong to the most neglected tropical diseases and have one of the highest rates of morbidity and mortality. The
Asrat Hailu, Choi, B., Abebe, T, Munder, Markus, Choi, B-S, Abebe Tamrat, Modolell, M, Choi Beak-San, Manuel Modolell, Hailu, A, Abebe, T., Fuentes, J., Modolell Manuel, Kropf Pascale, Abebe, Tamrat, Munder, M, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Modolell, M., Munder, M., Kropf, P., Kropf, Pascale, Beak-San Choi, Hailu, A., Fuentes, Jose M, Munder Markus, Fuentes Jose M., Pascale Kropf, Muller, I, Fuentes, JM, Jose M. Fuentes, Müller Ingrid, Jose M Fuentes, Hailu Asrat, Choi, Beak-San, Hailu, Asrat, Modolell, Manuel, Müller, I., Tamrat Abebe   +40 more
core   +1 more source

The Oral‐Gut Axis: Bidirectional Interactions Between Microbiome and Diseases

Journal of Periodontal Research, EarlyView.
This study aims to summarize the mechanisms underlying ectopic colonization of the gut by oral pathobionts and the microbial and host factors that regulate this process. ABSTRACT Increased colonization of typically oral microorganisms is frequently observed in the gut mucosa or lumen of individuals with gastrointestinal disorders, including patients ...
Shinya Ebihara, Nobuhiko Kamada
wiley   +1 more source

CD4+ T Cell‐Intrinsic Arg1 Regulates Th1 Dynamics in Influenza: Functional and Translational Implications for Infection and Cancer Inflammation

Allergy, EarlyView.
Anishaa Balaji, Sophia N. Karagiannis, Alexandra J. McCraw   +2 more
wiley   +1 more source

Investigating GERMs: how genotype, environment, and rhizosphere microbiome interactions underlie heat response in maize and sorghum

New Phytologist, EarlyView.
Three genotypes – a heat‐resistant maize (Zea mays), a heat‐susceptible maize, and a sorghum (Sorghum bicolor) variety – were grown to the V4 stage in growth chambers under optimal conditions or subjected to heat stress. Plants were grown in soil containing a complex microbial community, or in the same soil with a depleted microbiome.
Nate Korth, Isabella Borrero, Katelyn Rumley, Alex L. Woodley, Mallory J. Choudoir, Joseph L. Gage   +5 more
wiley   +1 more source

Role of polyamine metabolism in plant pathogen interactions

, 2017
Polyamines are aliphatic amines found in all living cells, and they are necessary for several fundamental cell processes. Their protective role against various abiotic stress factors has been reported in different plant species, while the mechanism by ...
Magda Pal*, Tibor Janda, Pal M
core   +1 more source

Thioredoxin system modulates metabolic and stomatal responses to elevated CO2 in Arabidopsis

New Phytologist, EarlyView.
Integrative model of extraplastidial NADPH‐dependent thioredoxin reductase/thioredoxin system‐mediated regulation of stomatal function, redox homeostasis, and metabolic responses under ambient and elevated CO2 in Arabidopsis thaliana. Summary The NADPH‐dependent thioredoxin reductase/thioredoxin (NTR/TRX) system plays a central role in maintaining ...
Paula da Fonseca‐Pereira, Domingos F. Mélo Neto, Rita de Cássia Monteiro‐Batista, Daniel Gomes Coelho, Jaciara Lana‐Costa, Leonardo Perez de Souza, Ina Krahnert, Danilo M. Daloso, Jorge Gago, Alisdair R. Fernie, Wagner L. Araújo, Adriano Nunes‐Nesi   +11 more
wiley   +1 more source

Deciphering Cold Stress Resilience: Multiomics Insights in Contrasting Wheat Genotypes From the Western Himalayas

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cold stress threatens wheat productivity, particularly in regions with extreme climatic conditions. To elucidate the molecular mechanisms underlying wheat's response to cold stress, we performed a multiomics analysis integrating lipidomics, transcriptomics, proteomics and metabolomics.
Sofora Jan, Farkhandah Jan, Mukesh Rathore, Yogita Singh, Prexha Kapoor, Palak Chaturvedi, Arindam Ghatak, Palakurthi Ramesh, Upendra Kumar, Manoj Prasad, Sundeep Kumar, Sachin Rustgi, Wolfram Weckwerth, Sanjay Kalia, Rajeev Kumar Varshney, Reyazul Rouf Mir   +15 more
wiley   +1 more source

Sweet Potato Gene Clusters Control Anthocyanin Biosynthesis and Leaf Morphology

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sweet potato (Ipomoea batatas) exhibits diversity in pigmentation and leaf morphology, yet the genetic architecture and regulatory organisation underlying these traits remain poorly resolved, particularly with respect to organ‐specific control.
Dong An, Tiechen Shen, Shiyu Wu, Yanshen Li, Weijuan Fan, Mengxiao Yan, Yinghui Meng, Xinyi Wang, Ximing Xu, Zunfu Lv, Ling Yuan, Jun Yang, Guoquan Lu, Hongxia Wang   +13 more
wiley   +1 more source