Results 101 to 110 of about 973,687 (259)

Urinary and Faecal Amino‐Acids as Biomarkers for Colorectal Neoplasia in Lynch Syndrome—A Prospective Longitudinal Study

International Journal of Cancer, EarlyView.
ABSTRACT In Lynch syndrome, colonoscopy surveillance for colorectal cancer (CRC) is burdensome and post‐colonoscopy CRCs still occur. Unlike the faecal immunochemical test (FIT), gut metabolomic alterations including amino‐acids have shown potential as non‐invasive biomarkers for detecting both advanced and non‐advanced sporadic colorectal neoplasia ...
Roza C. M. Opperman, Elsa L. S. A. van Liere, Animesh Acharjee, Sudip Mondal, Eduard A. Struys, Andreas Antoniadis, Jasmijn E. B. de Boer, Shivra R. Siriram, Abdellatif Bakkali, Sofie Bosch, Maarten A. J. M. Jacobs, Jan Jacob Koornstra, Johan P. Kuijvenhoven, Monique E. van Leerdam, Manon C. W. Spaander, Tim G. J. de Meij, Evelien Dekker, Dewkoemar Ramsoekh, Nanne K. H. de Boer   +18 more
wiley   +1 more source

Polyamine metabolic reprogramming in ependymal cells promotes endogenous repair after spinal cord injury

Neurobiology of Disease
The mechanisms underlying the activation of endogenous stem cells following spinal cord injury (SCI) remain a fundamental challenge in neural regeneration.
Yaozhi He, Qishun Liang, Jiawei Wang, Yuxuan Li, Zhiyuan Li, Dingjun Xu, Xiang Fang, Mengxian Jia, Qichuan Zhuge, Jian Xiao, Maoqiang Li, Changnan Xie, Honglin Teng   +12 more
doaj   +1 more source

Polyamine Metabolism in Flax in Response to Treatment with Pathogenic and Non-pathogenic Fusarium Strains

Frontiers in Plant Science, 2015
Flax crop yield is limited by various environmental factors, but the largest crop losses worldwide are caused by Fusarium infection. Polyamines are one of the many metabolites possibly involved in the plant response to infection.
Wioleta eWojtasik, Anna eKulma, Katarzyna eNamysł, Marta ePreisner, Jan eSzopa   +4 more
doaj   +1 more source

The Role of Polyamine Metabolism in Neuronal Injury Following Cerebral Ischemia

, 2009
Stroke is a leading cause of morbidity and mortality in the US, with secondary damage following the initial insult contributing significantly to overall poor outcome.
Starke, Robert M, McCullough-Hicks, Margy E, Otten, Marc L, Kim, Grace H, Rynkowski, Michal, Connolly, E. Sander, Dash, Kelly A, Komotar, Ricardo J, Kellner, Christopher P, Garrett, Matthew C, Merkow, Maxwell B   +10 more
core   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Role of polyamine metabolism in plant pathogen interactions

, 2017
Polyamines are aliphatic amines found in all living cells, and they are necessary for several fundamental cell processes. Their protective role against various abiotic stress factors has been reported in different plant species, while the mechanism by ...
Magda Pal*, Tibor Janda, Pal M
core   +1 more source

The Oncologic Ambivalence of Longevity Interventions in Photoaged Skin

JEADV Clinical Practice, EarlyView.
This graphical abstract presents a stage‐dependent framework for longevity interventions in photoaged skin. UV exposure drives progression from photodamage to field cancerization and skin cancer. Systemic interventions may modulate stress‐response pathways throughout the body, whereas energy‐based procedures generate spatially confined responses ...
Erik Senger, Lea Kurzen, Hjalmar Kurzen
wiley   +1 more source

Bio‐Derived Carbon Nanoparticles: A Green Amendment for Alleviating Heavy Metals in Soil–Plant Systems

Land Degradation &Development, EarlyView.
ABSTRACT Heavy metal (HM) contamination of soil–plant systems poses persistent ecological and health risks, driving interest in nanoparticle‐based remediation. Although conventional chemically synthesized nanoparticles (CSNPs) are effective, their energy‐intensive production and residual toxicity limit sustainable deployment.
Babar Hussain, Muhammad Nauman, Zahid Hussain, Palanisamy Vasudhevan, Abdulaziz G. Alghamdi, Shiyong Sun, Shengyan Pu   +6 more
wiley   +1 more source

An overview of polyamine metabolism in pancreatic ductal adenocarcinoma

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest major cancers, with a five year survival rate of less than 8%. With current therapies only giving rise to modest life extension, new approaches are desperately needed.
Otto Phanstiel, Phanstiel, Otto
core   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source