Results 61 to 70 of about 1,489,782 (254)

Eggs of the mosquito Aedes aegypti survive desiccation by rewiring their polyamine and lipid metabolism

PLoS Biology, 2023
Upon water loss, some organisms pause their life cycles and escape death. While widespread in microbes, this is less common in animals. Aedes mosquitoes are vectors for viral diseases.
A. Prasad, Sreesa Sreedharan, B. Bakthavachalu, Sunil Laxman   +3 more
semanticscholar   +1 more source

The expansive effects of polyamines on the metabolism and virulence of Streptococcus pneumoniae

Pneumonia, 2021
Polyamines are common intracellular metabolites of nearly all cells, and their conservation across a vast diversity of cells suggests critical roles for these compounds in cellular physiology.
Bindu Nanduri, Edwin Swiatlo
doaj   +1 more source

Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases

Frontiers in Nutrition, 2019
The polyamines putrescine, spermidine, and spermine are widely distributed polycationic compounds essential for cellular functions. Intracellular polyamine pools are tightly regulated by a complex regulatory mechanism involving de novo biosynthesis ...
Bruno Ramos-Molina, Bruno Ramos-Molina, Maria Isabel Queipo-Ortuño, Maria Isabel Queipo-Ortuño, Ana Lambertos, Ana Lambertos, Francisco J. Tinahones, Francisco J. Tinahones, Rafael Peñafiel, Rafael Peñafiel   +9 more
doaj   +1 more source

Polyamine Metabolism for Drug Intervention in Trypanosomatids

Pathogens
Neglected tropical diseases transmitted by trypanosomatids include three major human scourges that globally affect the world’s poorest people: African trypanosomiasis or sleeping sickness, American trypanosomiasis or Chagas disease and different types of
Y. Pérez-Pertejo, C. García-Estrada, M. Martínez-Valladares, Sankaranarayanan Murugesan, Rosa M. Reguera, R. Balaña-Fouce   +5 more
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Polyamine Metabolism in Brain Health and Disease

Neuropharmacology and Therapy
Polyamines, primarily spermidine and spermine, are small polycationic molecules essential for cell growth, signaling, and survival. Through electrostatic interactions with nucleic acids, lipids, and proteins, they regulate gene expression, organelle ...
Xianzun Tao, Tracey Nassuna, R. Grace Zhai   +2 more
doaj   +1 more source

VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms

Cell Reports
SUMMARY Myeloid-derived suppressor cells (MDSCs) impair antitumor immune responses. Identifying regulatory circuits during MDSC development may bring new opportunities for therapeutic interventions.
Keman Zhang, Amin Zakeri, Tyler Alban, Juan Dong, H. Ta, Ajay Zalavadia, Andrelie Branicky, Haoxin Zhao, I. Juric, Hanna Husich, P. Parthasarathy, Amit Rupani, Judith Drazba, Abhishek A. Chakraborty, Stanley Ching-Cheng Huang, Timothy Chan, Stefanie Avril, L. Wang   +17 more
semanticscholar   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

Regulating Polyamine Metabolism by miRNAs in Diabetic Cardiomyopathy

Current Diabetes Reports, 2021
Insulin is at the heart of diabetes mellitus (DM). DM alters cardiac metabolism causing cardiomyopathy, ultimately leading to heart failure. Polyamines, organic compounds synthesized by cardiomyocytes, have an insulin-like activity and effect on glucose ...
Tyler N. Kambis, Hadassha M. N. Tofilau, Flobater Gawargi, Surabhi Chandra, P. Mishra   +4 more
semanticscholar   +1 more source

Polyamine Acetylation Modulates Polyamine Metabolic Flux, a Prelude to Broader Metabolic Consequences [PDF]

Journal of Biological Chemistry, 2008
Recent studies suggest that overexpression of the polyamine-acetylating enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) significantly increases metabolic flux through the polyamine pathway. The concept derives from the observation that SSAT-induced acetylation of polyamines gives rise to a compensatory increase in biosynthesis and presumably ...
Debora L, Kramer, Paula, Diegelman, Jason, Jell, Slavoljub, Vujcic, Salim, Merali, Carl W, Porter   +5 more
openaire   +2 more sources