Results 61 to 70 of about 29,877 (250)
Polyamine Drug Discovery: Synthetic Approaches to Therapeutic Modulators of Polyamine Metabolism
, 2011 Numerous synthetic compounds have been described that either act as inhibitors of enzymes involved in polyamine metabolism or otherwise modulate these pathways.
Patrick M. Woster
core +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum [PDF]
, 2010 Inhibition of polyamine biosynthesis and/or the perturbation of polyamine functionality have been exploited with success against parasitic diseases such as Trypanosoma infections.
Williams, Marni +7 more
core +1 more source
Progress of metabolomics‐centric multi‐omics research in medicine
iMetaOmics, EarlyView.The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang +6 more
wiley +1 more source
Polyamine Metabolism for Drug Intervention in Trypanosomatids [PDF]
26 páginas, 10 figuras.Neglected tropical diseases transmitted by trypanosomatids include three major human scourges that globally affect the world's poorest people: African trypanosomiasis or sleeping sickness, American trypanosomiasis or Chagas disease
María Martínez-Valladares +11 more
core +2 more sources
Irrigation and Drainage, EarlyView.ABSTRACT Climate change is making water availability more uncertain, with growing consequences for the productivity and long‐term sustainability of tropical and subtropical fruit orchards. Mangifera indica L. and Persea americana Mill. both require large amounts of water to sustain growth and productivity.
Eleonora Cataldo
wiley +1 more source
Reduction of spermine synthase enhances autophagy to suppress Tau accumulation
Cell Death and DiseasePrecise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder–Robinson intellectual disability syndrome (SRS), characterized by significant spermidine accumulation and autophagy blockage in ...
Xianzun Tao +7 more
doaj +1 more source
New Plant Protection, EarlyView.We developed a genome‐integrated CRISPR/Cas12a system for Xenorhabdus budapestensis XBD8, which enables precise deletion or replacement of DNA fragments ranging from 379 to 45,168 bp, with a success rate exceeding 90%. Application of this tool for the dynamic regulation of fabclavine‐8 biosynthesis resulted in a 1.90‐fold increase in production ...
Wenfeng Gan +4 more
wiley +1 more source
Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease
Portal Hypertension &Cirrhosis, EarlyView.MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang +5 more
wiley +1 more source
Differences in Polyamine Metabolism between Carcinomatous and Uninvolved Human Breast Tissues
The International Journal of Biological Markers, 1986 The polyamine biosynthetic enzymes ODC and SAMDC show higher activity in carcinomatous human breast tissue than in uninvolved tissue of the same breast; the interconversion enzyme PAO shows significantly lower activity in carcinomatous than uninvolved ...
Marta Romano +4 more
doaj +1 more source