Results 21 to 30 of about 65,399 (230)

Design, Synthesis and biological evaluation of novel acridine-polyamine conjugates against prostate cancer [PDF]

, 2009
Prostate cancer is the most common cause of cancer death in men, aged 85 and over. Androgen receptor, a single polypeptide with three functional domains is very important during initiation and progression of the disease.
Maurice, HB, Karodia, N, Phillips, Roger
core   +2 more sources

Investigation of The Roles of Hydrogen Peroxide and NADPH Oxidase in The Regulation of Polyamine Metabolism in Maize Plants under Drought Stress Conditions

Journal of Agricultural Sciences, 2022
The relationship between hydrogen peroxide and the metabolism of polyamines and the role of NADPH oxidase (NOX) in that relationship under drought conditions remains unclear.
Aykut Sağlam, Mehmet Demiralay, Fuat Yetişsin, Asım Kadıoğlu   +3 more
doaj   +1 more source

The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment

Frontiers in Immunology, 2022
The study of metabolism provides important information for understanding the biological basis of cancer cells and the defects of cancer treatment. Disorders of polyamine metabolism is a common metabolic change in cancer.
Jiachun Lian, Jiachun Lian, Yanfang Liang, Hailiang Zhang, Hailiang Zhang, Minsheng Lan, Ziyu Ye, Ziyu Ye, Ziyu Ye, Bihua Lin, Bihua Lin, Bihua Lin, Xianxiu Qiu, Xianxiu Qiu, Xianxiu Qiu, Jincheng Zeng, Jincheng Zeng, Jincheng Zeng, Jincheng Zeng   +18 more
doaj   +1 more source

SAT1-Induced Spermidine Depletion Potentiates Food Allergy. [PDF]

Adv Sci (Weinh)
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Liu M, Zhang B, Wang J, Jiang Y, Han S, Wang Q, Zeng L, Wang J, Che H.   +8 more
europepmc   +2 more sources

Norspermidine is not a self-produced trigger for biofilm disassembly [PDF]

, 2014
Formation of Bacillus subtilis biofilms, consisting of cells encapsulated within an extracellular matrix of exopolysaccharide and protein, requires the polyamine spermidine.
Stanley-Wall, Nicola R.; id_orcid, Hobley, Laura, Kim, Sok Ho, Stanley-Wall, Nicola R., Michael, Anthony J., Maezato, Yukari, Fairlamb, Alan H.; id_orcid, Fairlamb, Alan H., Wyllie, Susan   +8 more
core   +1 more source

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma

Frontiers in Oncology, 2012
Polyamines are highly regulated essential cations that are elevated in rapidly proliferating tissues, including diverse cancers. Expression analyses in neuroblastomas suggest that upregulation of polyamine pro-synthetic enzymes and downregulation of ...
Laura Dawn Gamble, Michael D Hogarty, Xuenyuan eLiu, David S Ziegler, David S Ziegler, Glenn M Marshall, Glenn M Marshall, Murray D Norris, Michelle eHaber   +8 more
doaj   +1 more source

Antitumor potential of polyamines in cancer

Acta Biochimica et Biophysica Sinica
The dysregulation of polyamines in tumors has made polyamine metabolism an appealing target for cancer therapy. Gene mutations drive the reprogramming of polyamine metabolism in tumors, presenting promising opportunities for clinical treatment.
Liu He, Liu Yi, Wang Xinyue, Xiao Zhiwen, Ni Quanxing, Yu Xianjun, Luo Guopei   +6 more
doaj   +1 more source

Structure-activity relationship of polyamine conjugates for uptake via polyamine transport system [PDF]

, 2019
High toxicity of anticancer drugs led to development of targeted drug delivery directly to the specific organs. Polyamine transport system (PTS) of mammalian cells is one of the targets for a cell-selective drug delivery of polyamine-drug conjugates into
Sadeghi-aliabadi, Hojjat, Saghaie, Lotfollah, Nazifi, Mohamad Reza, Fassihi, Afshin   +3 more
core   +1 more source

Polyamine-Modified Gold Nanoparticles Readily Adsorb on Cell Membranes for Bioimaging

, 2019
The surface modification of nanoparticles (NPs) can enhance cellular and intracellular targeting. A new type of polyamine-modified gold NPs (AuNPs) are designed and synthesized, which can be selectively absorbed onto the cell membrane.
Zhong-Chao Cai (7512011), Bing-Jie Zhu (7512008), Chaojie Wang (2175530), Xiang-Fu Du (7512005), Mei-Xia Zhao (2588920)   +4 more
core   +1 more source

The mechanisms by which polyamines accelerate tumor spread

Journal of Experimental & Clinical Cancer Research, 2011
Increased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for polyamine synthesis. In addition to their de novo
Soda Kuniyasu
doaj   +1 more source