Results 21 to 30 of about 58,354 (282)
Polyamine–Drug Conjugates: Do They Boost Drug Activity?
Molecules, 2023 Over the past two decades, the strategy of conjugating polyamine tails with bioactive molecules such as anticancer and antimicrobial agents, as well as antioxidant and neuroprotective scaffolds, has been widely exploited to enhance their pharmacological ...
Filippo Basagni +3 more
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Biomedicines, 2023 Several mechanisms strictly regulate polyamine concentration, and blood polyamines are excreted in urine. This indicates polyamine accumulation in renal dysfunction, and studies have shown increased blood polyamine concentrations in patients with renal ...
Hidenori Sanayama +12 more
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Biomolecules, 2023 Cells acquire polyamines putrescine (PUT), spermidine (SPD) and spermine (SPM) via the complementary actions of polyamine uptake and synthesis pathways.
Marine Houdou +9 more
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Mathematical modelling of polyamine metabolism in bloodstream-form trypanosoma brucei: An application to drug target identification [PDF]
, 2013 © 2013 Gu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Desmond J Higham +16 more
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Medical Sciences, 2017 Increased polyamine biosynthesis activity and an active polyamine transport system are characteristics of many cancer cell lines and polyamine depletion has been shown to be a viable anticancer strategy.
Minpei Wang +2 more
doaj +1 more source
Frontiers in Nutrition, 2019 The polyamines spermine, spermidine, and putrescine are involved in various biological processes, notably in cell proliferation and differentiation, and also have antioxidant properties. Dietary polyamines have important implications in human health, mainly in the intestinal maturation and in the differentiation and development of immune system.
Nelly C. Muñoz-Esparza +15 more
openaire +4 more sources
Structural basis of antizyme-mediated regulation of polyamine homeostasis [PDF]
, 2017 Polyamines are organic polycations essential for cell growth and differentiation; their aberrant accumulation is often associated with diseases, including many types of cancer.
詹迺立 +1 more
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Polyamine-Modified Gold Nanoparticles Readily Adsorb on Cell Membranes for Bioimaging [PDF]
, 2019 The surface modification of nanoparticles (NPs) can enhance cellular and intracellular targeting. A new type of polyamine-modified gold NPs (AuNPs) are designed and synthesized, which can be selectively absorbed onto the cell membrane.
Zhong-Chao Cai (7512011) +4 more
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Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers
Medical Sciences, 2017 Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC).
Chelsea Massaro +2 more
doaj +1 more source
Norspermidine is not a self-produced trigger for biofilm disassembly [PDF]
, 2014 Formation of Bacillus subtilis biofilms, consisting of cells encapsulated within an extracellular matrix of exopolysaccharide and protein, requires the polyamine spermidine.
Stanley-Wall, Nicola R.; id_orcid +8 more
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