Results 21 to 30 of about 63,812 (294)
Polyamine Metabolism in Brain Health and Disease [PDF]
Neuropharmacology and TherapyPolyamines, primarily spermidine and spermine, are small polycationic molecules essential for cell growth, signaling, and survival. Through electrostatic interactions with nucleic acids, lipids, and proteins, they regulate gene expression, organelle ...
Xianzun Tao +2 more
doaj +2 more sources
Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging [PDF]
Amino AcidsInterest in RNA editing has emerged in molecular medicine due to its widespread dysregulation and therapeutic potential. Its regulatory mechanisms in governing non-coding RNAs, especially microRNAs (miRNAs) remain largely unresolved. Emerging evidence in
Miora Bruna Marielle Ramamonjiharisoa +1 more
doaj +2 more sources
Biomolecules, 2023 Polyamine homeostasis is disturbed in several human diseases, including cancer, which is hallmarked by increased intracellular polyamine levels and an upregulated polyamine transport system (PTS).
Sarah van Veen +7 more
doaj +1 more source
ATP13A3 facilitates polyamine transport in human pancreatic cancer cells
Scientific Reports, 2022 The purpose of this study is to provide an increased understanding of the molecular mechanisms responsible for mammalian polyamine transport, a process that has been a long-standing ‘black box’ for the polyamine field.
Vandana Sekhar +2 more
doaj +1 more source
Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity
Cells, 2022 Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent work has highlighted that polyamines exert profound roles on the mammalian immune system, particularly inflammation and cancer. The mechanisms by which they control
Tzu-yi Chia, Andrew Zolp, Jason Miska
doaj +1 more source
Design, Synthesis and biological evaluation of novel acridine-polyamine conjugates against prostate cancer [PDF]
, 2009 Prostate cancer is the most common cause of cancer death in men, aged 85 and over. Androgen receptor, a single polypeptide with three functional domains is very important during initiation and progression of the disease.
Maurice, HB, Karodia, N, Phillips, Roger
core +3 more sources
Upregulation of Polyamine Transport in Human Colorectal Cancer Cells
Biomolecules, 2020 Polyamines are essential growth factors that have a positive role in cancer cell growth. Their metabolic pathway and the diverse enzymes involved have been studied in depth in multiple organisms and cells.
Misael Corral, Heather M. Wallace
doaj +1 more source
Viruses, 2021 Enteroviruses, including Coxsackievirus B3 (CVB3), are pervasive pathogens that cause significant disease, including cardiomyopathies. Unfortunately, no treatments or vaccines are available for infected individuals.
Bridget M. Hulsebosch, Bryan C. Mounce
doaj +1 more source
Functionalized polyamine synthesis with photoredox catalysis [PDF]
, 2023 Polyamines, such as putrescine and spermidine, are pivotal in various biological processes across living organisms. Despite their significance, structurally modified polyamines offer a less-explored avenue for discovering bioactive compounds.
Yuta, Makihara +4 more
core +2 more sources
Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis. [PDF]
PLoS ONE, 2013 Polyamines (spermine and spermidine) play many important roles in cellular function and are supplied from the intestinal lumen. We have shown that continuous high polyamine intake inhibits age-associated pathologies in mice.
Kuniyasu Soda +4 more
doaj +1 more source