Results 1 to 10 of about 128 (69)
Technology in Cancer Research and Treatment, 2020 Thymoquinone (TQ), a natural anticancer agent exerts cytotoxic effects on several tumors by targeting multiple pathways, including apoptosis. Difluoromethylornithine (DFMO), an irreversible inhibitor of the ornithine decarboxylase (ODC) enzyme, has shown
Syed Shoeb Razvi +2 more
exaly +2 more sources
Frontiers in Oncology, 2023 ObjectivesTo evaluate the efficacy of Difluoromethylornithine (DFMO) chemoprevention in the high-risk population for colorectal cancer (CRC).MethodsMeta-analysis was conducted to assess the caliber of the included literature by searching five databases ...
Lifeng Yang +3 more
doaj +1 more source
Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci
Scientific Reports, 2022 Polyamines are small cationic molecules that have been linked to various cellular processes including replication, translation, stress response and recently, capsule regulation in Streptococcus pneumoniae (Spn, pneumococcus).
Moses B. Ayoola +7 more
doaj +1 more source
Frontiers in Chemistry, 2021 Targeting the polyamine biosynthetic pathway by inhibiting ornithine decarboxylase (ODC) is a powerful approach in the fight against diverse viruses, including SARS-CoV-2.
Joanna Bojarska +8 more
doaj +1 more source
A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma. [PDF]
PLoS ONE, 2015 Neuroblastoma (NB) is the most common cancer in infancy and most frequent cause of death from extracranial solid tumors in children. Ornithine decarboxylase (ODC) expression is an independent indicator of poor prognosis in NB patients.
Giselle L Saulnier Sholler +21 more
doaj +1 more source
Biomolecules, 2021 Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by ...
Mervi T. Hyvönen +4 more
doaj +1 more source
PLoS ONE, 2020 BACKGROUND:The plenteous resistance to and undesirable consequences of the existing antipiroplasmic therapies have emphasized the urgent need for new chemotherapeutics and drug targets for both prophylaxis and chemotherapy.
Gaber El-Saber Batiha +6 more
doaj +1 more source
Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. [PDF]
PLoS ONE, 2011 Helicobacter pylori infects half the world's population, and carriage is lifelong without antibiotic therapy. Current regimens prescribed to prevent infection-associated diseases such as gastroduodenal ulcers and gastric cancer can be thwarted by ...
Daniel P Barry +7 more
doaj +1 more source
Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells
Medical Sciences, 2022 Ovarian cancer accounts for 3% of the total cancers in women, yet it is the fifth leading cause of cancer deaths among women. The BRCA1/2 germline and somatic mutations confer a deficiency of the homologous recombination (HR) repair pathway.
Olivia El Naggar +3 more
doaj +1 more source
Polyamines Participate in Mycorrhizal and Root Development of Citrus (Citrus tangerine) Seedlings
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2010 A pot experiment was conducted to study the effects of difluoromethylornithine (DFMO, an irreversible inhibitor of putrescine (Put) formation) alone or combination with Put on mycorrhizal and root development of Citrus tangerine seedlings inoculated with
Qiang-Sheng WU +3 more
doaj +1 more source