Inhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice [PDF]
Pulmonary Circulation, 2020 Endotoxemia impairs hypoxic pulmonary vasoconstriction which leads to systemic hypoxemia. This derogation is attributable to increased activity of nitric oxide synthase 2 and arginase metabolism. Gene expression analysis has shown increased expression of
P.H. Gebauer +4 more
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DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD).
Mingu Gordon Park +2 more
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Metabolic Characterization of Hyoscyamus niger Ornithine Decarboxylase [PDF]
Frontiers in Plant Science, 2019 Ornithine decarboxylase (ODC) catalyzes ornithine decarboxylation to yield putrescine, a key precursor of polyamines, and tropane alkaloids (TAs). Here, to investigate in depth the role of ODC in polyamine/TA biosynthesis and to provide a candidate gene ...
Tengfei Zhao +9 more
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Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase. [PDF]
PLoS ONE, 2019 Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, organic cations that are implicated in many cellular processes. The enzyme is regulated at the post-translational level by an unusual system that includes antizymes (AZs ...
Ana Lambertos, Rafael Peñafiel
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Target of Rapamycin Mediated Ornithine Decarboxylase Antizyme Modulate Intracellular Putrescine and Ganoderic Acid Content in Ganoderma lucidum [PDF]
Microbiology Spectrum, 2022 Putrescine (Put) has been shown to play an important regulatory role in cell growth in organisms. As the primary center regulating the homeostasis of polyamine (PA) content, ornithine decarboxylase antizyme (AZ) can regulate PA content through feedback ...
Tao Wu +12 more
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Ornithine decarboxylase as a therapeutic target for endometrial cancer. [PDF]
PLoS ONE, 2017 Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. We noted ubiquitous expression of ODC1 in our published endometrial cancer gene array data and
Hong Im Kim +9 more
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Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep [PDF]
Journal of Animal Science and Biotechnology, 2018 Background Polyamines stimulate DNA transcription and mRNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and survival of conceptuses (embryo/fetus ...
Yasser Y. Lenis +8 more
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A safety catch for ornithine decarboxylase degradation [PDF]
Microbial Cell, 2015 Christof Taxis
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Ornithine Decarboxylase Activity Is Required for Prostatic Budding in the Developing Mouse Prostate. [PDF]
PLoS ONE, 2015 The prostate is a male accessory sex gland that produces secretions in seminal fluid to facilitate fertilization. Prostate secretory function is dependent on androgens, although the mechanism by which androgens exert their effects is still unclear ...
Melissa Gamat +4 more
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The effect of folic acid treatment on the post-harvest life of cucumber through influencing the activity of enzymes involved in the biosynthesis of proline, polyamine, and chlorophyll-degradation [PDF]
فیزیولوژی محیطی گیاهی, 2022 In this study, the mechanism of cold stress tolerance in cucumber fruits pretreated with folic acid was investigated. Control group and the group treated with 5 mgL-1 folic acid were stored for 15 days at 4 °-C.
Parviz Malekzadeh
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