Results 1 to 10 of about 7,080 (124)

In Silico Screening of Cannabis sativa Phytochemicals as Potential Ornithine Decarboxylase Inhibitors for Anti-Leishmanial Drug-Prioritized Compound Development [PDF]

Biology
Leishmaniasis remains a major neglected tropical disease with limited therapeutic options, increasing drug resistance, and significant treatment-associated toxicity.
Abdul Haseeb Khan, Munazza Kanwal, Syed Babar Jamal, Kashaf Maheen, Sunia Mohsin, Laiba Hussain, Fawaz Al-Hussain, Kaleem Imdad, Shumaila Naz, Shahid Bashir   +9 more
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Multi-Temperature Crystallography of Polyamine Biosynthesis Enzymes Reveals Differing Active Site Conformations at RT than 100K [PDF]

Structural Dynamics
The polyamine biosynthetic pathway synthesizes the polyamines putrescine, spermidine, and spermine from ornithine and S-adenosyl methionine. These polyamines are important molecules in metabolism and are associated with growth and proliferation of cells ...
Jonathan A Clinger
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The remarkable legacy of the K6/ODC mouse: mechanisms of polyamine-promoted tumorigenesis revealed [PDF]

Amino Acids
Using the well-studied two-stage model of skin carcinogenesis, the first transgenic mouse with targeted expression of a polyamine metabolic enzyme was generated 30 years ago.
Susan K. Gilmour
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Characterization and Mechanism of Tea Polyphenols Inhibiting Biogenic Amine Accumulation in Marinated Spanish Mackerel

Foods, 2023
Putrescine is a low-molecular-weight organic compound that is widely found in pickled foods. Although the intake of biogenic amines is beneficial to humans, an excessive intake can cause discomfort.
Zhe Xu, Jiale Chang, Jiamin Zhou, Yixin Shi, Hui Chen, Lingyu Han, Maolin Tu, Tingting Li   +7 more
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Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells

Frontiers in Pharmacology, 2020
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation ...
Freddy López-Contreras, Freddy López-Contreras, Matías Muñoz-Uribe, Jorge Pérez-Laines, Laura Ascencio-Leal, Andrés Rivera-Dictter, Antonia Martin-Martin, Rafael A. Burgos, Pablo Alarcon, Rodrigo López-Muñoz   +9 more
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Polyamine Metabolism in Leishmania Parasites: A Promising Therapeutic Target

Medical Sciences, 2022
Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in humans and domestic animals worldwide. The need for new therapeutic strategies is urgent because no vaccine is available, and treatment options are limited due ...
Nicola S. Carter, Yumena Kawasaki, Surbhi S. Nahata, Samira Elikaee, Sara Rajab, Leena Salam, Mohammed Y. Alabdulal, Kelli K. Broessel, Forogh Foroghi, Alyaa Abbas, Reyhaneh Poormohamadian, Sigrid C. Roberts   +11 more
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DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD).
Mingu Gordon Park, Suyeon Yellena Kim, C. Justin Lee   +2 more
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Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase

Biomolecules, 2020
The biogenic polyamines, spermine, spermidine (Spd) and putrescine (Put) are present at micro-millimolar concentrations in eukaryotic and prokaryotic cells (many prokaryotes have no spermine), participating in the regulation of cellular proliferation and
Mervi T. Hyvönen, Tuomo A. Keinänen, Gulgina K. Nuraeva, Dmitry V. Yanvarev, Maxim Khomutov, Elena N. Khurs, Sergey N. Kochetkov, Jouko Vepsäläinen, Alexander A. Zhgun, Alex R. Khomutov   +9 more
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Putrescine Biosynthesis Inhibition in Tomato by DFMA and DFMO Treatment

Bio-Protocol, 2016
This protocol can be used to inhibit the biosynthesis of polyamines, specifically putrescine, in tomato plants grown with NH4+ as a solely N source. In general, polyamines are positively charged small metabolites implicated in physiological processes ...
Emma Fernández-Crespo, Ana González-Hernández, Loredana Scalschi, Eugenio Llorens, Pilar García-Agustín, Gemma Camañes   +5 more
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Mitogen‐Activated Protein Kinase and Intracellular Polyamine Signaling Is Involved in TRPV1 Activation–Induced Cardiac Hypertrophy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe transient receptor potential vanilloid type 1 (TRPV1) is expressed in the cardiovascular system, and increased TRPV1 expression has been associated with cardiac hypertrophy.
Mai Chen, Jiajia Xin, Baohui Liu, Liyang Luo, Jiayi Li, Wen Yin, Mingkai Li   +6 more
doaj   +1 more source