Results 11 to 20 of about 6,839 (201)

Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase. [PDF]

PLoS ONE, 2019
Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, organic cations that are implicated in many cellular processes. The enzyme is regulated at the post-translational level by an unusual system that includes antizymes (AZs ...
Ana Lambertos, Rafael Peñafiel
doaj   +3 more sources

DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD).
Mingu Gordon Park, Suyeon Yellena Kim, C. Justin Lee   +2 more
doaj   +2 more sources

Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase

Biomolecules, 2020
The biogenic polyamines, spermine, spermidine (Spd) and putrescine (Put) are present at micro-millimolar concentrations in eukaryotic and prokaryotic cells (many prokaryotes have no spermine), participating in the regulation of cellular proliferation and
Mervi T. Hyvönen, Tuomo A. Keinänen, Gulgina K. Nuraeva, Dmitry V. Yanvarev, Maxim Khomutov, Elena N. Khurs, Sergey N. Kochetkov, Jouko Vepsäläinen, Alexander A. Zhgun, Alex R. Khomutov   +9 more
doaj   +2 more sources

Purification and Characterization of Ornithine Decarboxylase from Aspergillus terreus; Kinetics of Inhibition by Various Inhibitors

Molecules, 2019
l-Ornithine decarboxylase (ODC) is the rate-limiting enzyme of de novo polyamine synthesis in humans and fungi. Elevated levels of polyamine by over-induction of ODC activity in response to tumor-promoting factors has been frequently reported.
Ashraf S.A. El-Sayed, Nelly M. George, Marwa A. Yassin, Bothaina A. Alaidaroos, Ahmed A. Bolbol, Marwa S. Mohamed, Amgad M. Rady, Safa W. Aziz, Rawia A. Zayed, Mahmoud Z. Sitohy   +9 more
doaj   +2 more sources

Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity [PDF]

Cancer Research, 2016
Abstract Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that is associated with cell growth and tumor formation. Existing catalytic inhibitors of ODC have lacked efficacy in clinical testing or displayed unacceptable toxicity.
Dong Joon, Kim, Eunmiri, Roh, Mee-Hyun, Lee, Naomi, Oi, Do Young, Lim, Myoung Ok, Kim, Young-Yeon, Cho, Angelo, Pugliese, Jung-Hyun, Shim, Hanyong, Chen, Eun Jin, Cho, Jong-Eun, Kim, Sun Chul, Kang, Souren, Paul, Hee Eun, Kang, Ji Won, Jung, Sung-Young, Lee, Sung-Hyun, Kim, Kanamata, Reddy, Young Il, Yeom, Ann M, Bode, Zigang, Dong   +21 more
openaire   +3 more sources

Polyphasic Characterization of Acetobacter indonesiensis UNPADCC 01-5 Isolated From a Traditional Fermented Food, Oncom Merah. [PDF]

Environ Microbiol Rep
The polyphasic approach (morphology, physiology, biochemistry and genetics) was used to characterize Acetobacter indonesiensis strain UNPADCC 01‐5, which was isolated from oncom merah. The strain's potential as a culture for acidic fermentations and a biofunctional agent was supported by its adaptive characteristics, which included acid tolerance ...
Syaputri Y, Zahra E, Azzahra RN, Annisa, Iswhara DA, Lengkey FO, Fauzia S, Jia X, Wulandari AP, Safitri R.   +9 more
europepmc   +2 more sources

Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells

Frontiers in Pharmacology, 2020
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation ...
Freddy López-Contreras, Freddy López-Contreras, Matías Muñoz-Uribe, Jorge Pérez-Laines, Laura Ascencio-Leal, Andrés Rivera-Dictter, Antonia Martin-Martin, Rafael A. Burgos, Pablo Alarcon, Rodrigo López-Muñoz   +9 more
doaj   +1 more source

Polyamine Metabolism in Leishmania Parasites: A Promising Therapeutic Target

Medical Sciences, 2022
Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in humans and domestic animals worldwide. The need for new therapeutic strategies is urgent because no vaccine is available, and treatment options are limited due ...
Nicola S. Carter, Yumena Kawasaki, Surbhi S. Nahata, Samira Elikaee, Sara Rajab, Leena Salam, Mohammed Y. Alabdulal, Kelli K. Broessel, Forogh Foroghi, Alyaa Abbas, Reyhaneh Poormohamadian, Sigrid C. Roberts   +11 more
doaj   +1 more source

Impairment of macrophage function by inhibitors of ornithine decarboxylase activity [PDF]

Infection and Immunity, 1987
The effects of irreversible inhibition of ornithine decarboxylase on the capacity of murine macrophages to take up a protozoan organism (Trypanosoma cruzi) or inert particles were investigated. Incubation of macrophage cultures with four different ornithine decarboxylase inhibitors, namely, DL-alpha-difluoromethylornithine (DFMO, 0.5 to 20 mM), delta ...
F, Kierszenbaum, J J, Wirth, P P, McCann, A, Sjoerdsma   +3 more
openaire   +2 more sources

An inhibitor of ornithine decarboxylase in the thymus and spleen of dexamethasone-treated rats [PDF]

Biochemical Journal, 1985
A marked decrease in activity of ornithine decarboxylase in thymus and spleen occurs soon after treatment of rats with a glucocorticoid. In the present study, evidence was obtained that extracts of these tissues prepared 5 h after administration of dexamethasone, when the enzyme activity is very low, contain an inhibitor of ornithine decarboxylase. The
P B, Bishop, J, Young, T, Peng, J F, Richards   +3 more
openaire   +4 more sources