Results 41 to 50 of about 6,839 (201)

Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells

, 1988
Treatment of L1210 cells with either of two inhibitors of S-adenosylmethionine decarboxylase (AdoMetDC), namely 5′-deoxy-5′-[N-methyl-N-[2-(amino-oxy)ethyl])aminoadenosine or 5′-deoxy-5′-[N-methyl-N-(3-hydrazinopropyl)]aminoadenosine, produced a large ...
Madhubala, R., Secrist, J. A., Pegg, A. E.   +2 more
core   +1 more source

Impact of nicotine pathway downregulation on polyamine biosynthesis and leaf ripening in tobacco

Plant Direct, 2021
Traditional breeding and molecular approaches have been used to develop tobacco varieties with reduced nicotine and secondary alkaloid levels. However, available low‐alkaloid tobacco varieties have impaired leaf quality likely due to the metabolic ...
Greta Nölke, Ivana Chudobova, Marcel Houdelet, Daniel Volke, Marcos Lusso, Jesse Frederick, Chengalrayan Kudithipudi, Yanxin Shen, Ujwala Warek, James A. Strickland, Dongmei Xu, Helga Schinkel, Stefan Schillberg   +12 more
doaj   +1 more source

Antizyme inhibitor 2 hypomorphic mice. New patterns of expression in pancreas and adrenal glands suggest a role in secretory processes. [PDF]

PLoS ONE, 2013
The intracellular levels of polyamines, polycations implicated in proliferation, differentiation and cell survival, are regulated by controlling their biosynthesis, catabolism and transport.
Carlos López-Garcia, Bruno Ramos-Molina, Ana Lambertos, Andrés J López-Contreras, Asunción Cremades, Rafael Peñafiel   +5 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Baicalein, 7,8-Dihydroxyflavone and Myricetin as Potent Inhibitors of Human Ornithine Decarboxylase

, 2022
Background: Human ornithine decarboxylase (ODC) is a well-known oncogene, and the discovery of ODC enzyme inhibitors is a beneficial strategy for cancer therapy and prevention.
Ju-Yi Hsieh, Yun-Chin Liu, Chang-Hsu Wang, Chi-Li Lin, Yi-Liang Liu, Guang-Yaw Liu, Hui-Chih Hung   +6 more
core  

Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model Suggests the Existence of Multiple Transport Systems

Medical Sciences, 2017
Increased polyamine biosynthesis activity and an active polyamine transport system are characteristics of many cancer cell lines and polyamine depletion has been shown to be a viable anticancer strategy.
Minpei Wang, Otto Phanstiel, Laurence von Kalm   +2 more
doaj   +1 more source

Monitoring and Mitigation Strategies for Hazardous Compounds in Chinese Rice Wine (Huangjiu): A Comprehensive Review

Food Safety and Health, EarlyView.
This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu, Zhiqiang Kong, Lin Li, Yifan Zhang, Bei Fan, Minmin Li   +5 more
wiley   +1 more source

Syntheses of ornithine decarboxylase inhibitors: D- and DL-.ALPHA.-hydrazinoornithine.

Chemical and Pharmaceutical Bulletin, 1976
The absolute configuration of optically active α-hydrazinoornithine which was prepared by the reaction of hydrazine with the α-bromo acid derived from L-ornithine was proved to be the D-configuration. In addition, racemic α-hydrazinoornithine was first prepared by two different methods.
SAWAYAMA, TADAHIRO, KINUGASA, HIROAKI, NISHIMURA, HARUKI   +2 more
openaire   +3 more sources

Macronutrient and micronutrient profiles of meat types: insights into human health and diet

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Despite considerable advances in global health and nutrition, emerging challenges such as population growth, climate change, and limited natural resources continue to threaten food security. Meat remains an essential component of the human diet, supplying high‐quality proteins, essential amino acids, lipids, vitamins, and minerals necessary ...
Özgül Anitaş, Serap Göncü, Fatma Hepsağ, Nazan Koluman, Yesim Ozogul   +4 more
wiley   +1 more source

Current Insight into Human Ornithine Aminotransferase: A Review

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human ornithine aminotransferase (hOAT) is a mitochondrial matrix pyridoxal‐5′‐phosphate enzyme (PLP) that catalyzes the reversible transfer of the δ‐amino group of L‐ornithine (L‐Orn) to α‐ketoglutarate (α‐KG) yielding glutamate‐5‐semialdehyde (GSA) and glutamate. GSA is prone to cyclize to Δ1‐pyrroline‐5‐carboxylate.
Fulvio Floriani, Carla Borri Voltattorni, Riccardo Montioli   +2 more
wiley   +1 more source