Results 21 to 30 of about 6,525 (164)

Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity [PDF]

Cancer Research, 2016
Abstract Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that is associated with cell growth and tumor formation. Existing catalytic inhibitors of ODC have lacked efficacy in clinical testing or displayed unacceptable toxicity.
Dong Joon, Kim, Eunmiri, Roh, Mee-Hyun, Lee, Naomi, Oi, Do Young, Lim, Myoung Ok, Kim, Young-Yeon, Cho, Angelo, Pugliese, Jung-Hyun, Shim, Hanyong, Chen, Eun Jin, Cho, Jong-Eun, Kim, Sun Chul, Kang, Souren, Paul, Hee Eun, Kang, Ji Won, Jung, Sung-Young, Lee, Sung-Hyun, Kim, Kanamata, Reddy, Young Il, Yeom, Ann M, Bode, Zigang, Dong   +21 more
openaire   +2 more sources

Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase.

PLoS ONE, 2019
Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, organic cations that are implicated in many cellular processes. The enzyme is regulated at the post-translational level by an unusual system that includes antizymes (AZs ...
Ana Lambertos, Rafael Peñafiel
doaj   +1 more source

Pharmacological Approaches to Antitrypanosomal Chemotherapy

Memorias do Instituto Oswaldo Cruz, 1999
There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and ...
Simon L Croft
doaj   +1 more source

Inhibition of putrescine biosynthesis enhanced salt stress sensitivity and decreased spermidine content in rice seedlings

Biologia Plantarum, 2017
The effect of polyamine biosynthesis inhibitors on the salt stress response of rice seedlings was investigated. For this, DL-α-difluoromethylarginine (DFMA) and DL-α-difluoromethylornithine (DFMO), two competitive inhibitors of arginine decarboxylase ...
A. Yamamoto, I.-S. Shim, S. Fujihara
doaj   +1 more source

Antizyme Inhibitors in Polyamine Metabolism and Beyond: Physiopathological Implications

Medical Sciences, 2018
The intracellular levels of polyamines, cationic molecules involved in a myriad of cellular functions ranging from cellular growth, differentiation and apoptosis, is precisely regulated by antizymes and antizyme inhibitors via the modulation of the ...
Bruno Ramos-Molina, Ana Lambertos, Rafael Peñafiel   +2 more
doaj   +1 more source

Glucocorticoids and Polyamine Inhibitors Synergize to Kill Human Leukemic CEM Cells

Neoplasia: An International Journal for Oncology Research, 2002
Glucocorticoids are well-known apoptotic agents in certain classes of lymphoid cell malignancies. Reduction of intracellular polyamine levels by use of inhibitors that block polyamine synthesis slows or inhibits growth of many cells in vitro.
Aaron L. Miller, Betty H. Johnson, Rheem D. Medh, Courtney M. Townsend, E. Brad Thompson   +4 more
doaj   +1 more source

Dual Inhibition of Ornithine Decarboxylase and A1 Adenosine Receptor Efficiently Suppresses Breast Tumor Cells

Frontiers in Oncology, 2021
Personized treatment of breast cancer is still a challenge, and more treatment options for breast cancer are warranted. Combination therapies have been a highly appreciated strategy for breast cancer treatment in recent years, and the development of new ...
Hongyan Ma, Hongyan Ma, Hongyan Ma, Qizhang Li, Qizhang Li, Jing Wang, Jing Wang, Jing Wang, Jing Pan, Jing Pan, Jing Pan, Zhengding Su, Zhengding Su, Sen Liu, Sen Liu, Sen Liu   +15 more
doaj   +1 more source

Intracellular polyamine pools, oligopeptide-binding protein A expression, and resistance to aminoglycosides in Escherichia coli

Memorias do Instituto Oswaldo Cruz, 2005
The role of intracellular free polyamine (putrescine and spermidine) pools in multiple resistance to aminoglycoside antibiotics was investigated among in vitro selected kanamycin-resistant Escherichia coli J53 mutants expressing diminished oligopeptide ...
Maria BR Acosta, Rita C Café Ferreira, Luís CS Ferreira, Sérgio Olavo P Costa   +3 more
doaj   +1 more source

Inhibition or promotion, the potential role of arginine metabolism in immunotherapy for colorectal cancer

All Life, 2023
Colorectal cancer (CRC) is the third most common cancer in the world, with increasing morbidity and mortality. The current diagnosis and treatment plan rely on early detection and comprehensive treatment based on surgery.
Chengyang Chen, Xia Jiang, Zengren Zhao
doaj   +1 more source

Antizyme Inhibitor 2-Deficient Mice Exhibit Altered Brain Polyamine Levels and Reduced Locomotor Activity

Biomolecules, 2022
Background: Alterations in the neural polyamine system are known to be associated with different brain pathological conditions. In addition, the regulation of enzymes involved in polyamine metabolism such as ornithine decarboxylase (ODC), antizymes (AZs),
Ana Lambertos, Maria Angeles Nuñez-Sanchez, Carlos López-García, Andrés Joaquín López-Contreras, Bruno Ramos-Molina, Rafael Peñafiel   +5 more
doaj   +1 more source