Results 21 to 30 of about 645,023 (159)

Intracellular polyamine pools, oligopeptide-binding protein A expression, and resistance to aminoglycosides in Escherichia coli

Memorias do Instituto Oswaldo Cruz, 2005
The role of intracellular free polyamine (putrescine and spermidine) pools in multiple resistance to aminoglycoside antibiotics was investigated among in vitro selected kanamycin-resistant Escherichia coli J53 mutants expressing diminished oligopeptide ...
Maria BR Acosta, Rita C Café Ferreira, Luís CS Ferreira, Sérgio Olavo P Costa   +3 more
doaj   +1 more source

Dual Inhibition of Ornithine Decarboxylase and A1 Adenosine Receptor Efficiently Suppresses Breast Tumor Cells

Frontiers in Oncology, 2021
Personized treatment of breast cancer is still a challenge, and more treatment options for breast cancer are warranted. Combination therapies have been a highly appreciated strategy for breast cancer treatment in recent years, and the development of new ...
Hongyan Ma, Hongyan Ma, Hongyan Ma, Qizhang Li, Qizhang Li, Jing Wang, Jing Wang, Jing Wang, Jing Pan, Jing Pan, Jing Pan, Zhengding Su, Zhengding Su, Sen Liu, Sen Liu, Sen Liu   +15 more
doaj   +1 more source

Plasmodium AdoMetDC/ODC bifunctional enzyme is essential for male sexual stage development and mosquito transmission

Biology Open, 2016
Polyamines are positively-charged organic molecules that are important for cellular growth and division. Polyamines and their synthesizing enzymes are particularly abundant in rapidly proliferating eukaryotic cells such as parasitic protozoa and cancer ...
Robert J. Hart, Atif Ghaffar, Shaymaa Abdalal, Benjamin Perrin, Ahmed S. I. Aly   +4 more
doaj   +1 more source

Inhibition or promotion, the potential role of arginine metabolism in immunotherapy for colorectal cancer

All Life, 2023
Colorectal cancer (CRC) is the third most common cancer in the world, with increasing morbidity and mortality. The current diagnosis and treatment plan rely on early detection and comprehensive treatment based on surgery.
Chengyang Chen, Xia Jiang, Zengren Zhao
doaj   +1 more source

Antizyme Inhibitor 2-Deficient Mice Exhibit Altered Brain Polyamine Levels and Reduced Locomotor Activity

Biomolecules, 2022
Background: Alterations in the neural polyamine system are known to be associated with different brain pathological conditions. In addition, the regulation of enzymes involved in polyamine metabolism such as ornithine decarboxylase (ODC), antizymes (AZs),
Ana Lambertos, Maria Angeles Nuñez-Sanchez, Carlos López-García, Andrés Joaquín López-Contreras, Bruno Ramos-Molina, Rafael Peñafiel   +5 more
doaj   +1 more source

Purification and Characterization of Ornithine Decarboxylase from Aspergillus terreus; Kinetics of Inhibition by Various Inhibitors

Molecules, 2019
l-Ornithine decarboxylase (ODC) is the rate-limiting enzyme of de novo polyamine synthesis in humans and fungi. Elevated levels of polyamine by over-induction of ODC activity in response to tumor-promoting factors has been frequently reported.
Ashraf S.A. El-Sayed, Nelly M. George, Marwa A. Yassin, Bothaina A. Alaidaroos, Ahmed A. Bolbol, Marwa S. Mohamed, Amgad M. Rady, Safa W. Aziz, Rawia A. Zayed, Mahmoud Z. Sitohy   +9 more
doaj   +1 more source

Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations

Frontiers in Cellular and Infection Microbiology, 2019
Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite Plasmodium falciparum in vitro and in vivo.
Kamal El Bissati, Henry Redel, Li-Min Ting, Joseph D. Lykins, Martin J. McPhillie, Rajendra Upadhya, Patrick M. Woster, Nigel Yarlett, Kami Kim, Kami Kim, Louis M. Weiss, Louis M. Weiss   +11 more
doaj   +1 more source

Distinct roles of putrescine and spermidine in the regulation of ornithine decarboxylase in Neurospora crassa. [PDF]

, 1985
We wished to identify metabolic signals governing changes in ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in Neurospora crassa.
Krasner, GN, Davis, RH, Ristow, JL, DiGangi, JJ   +3 more
core   +1 more source

MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis

Cell & Bioscience, 2022
Background Inhibitors of ornithine decarboxylase (ODC) are effective at preventing colorectal cancer (CRC). However, their high toxicity limits their clinical application.
Ningning Liu, Tianpeng Zhang, Clifford J. Steer, Guisheng Song   +3 more
doaj   +1 more source

Decarboxylation of arginine and ornithine by arginine decarboxylase purified from cucumber (Cucumis sativus) seedlings [PDF]

, 1986
A purified preparation of arginine decarboxylase from Cucumis sativus seedlings displayed ornithine decarboxylase activity as well. The two decarboxylase activities associated with the single protein responded differentially to agmatine, putrescine and ...
Adiga, PR, Prasad, GL
core   +3 more sources