Results 1 to 10 of about 87,049 (284)

Contribution to catalysis of ornithine binding residues in ornithine N5-monooxygenase [PDF]

Archives of Biochemistry and Biophysics, 2015
The SidA ornithine N5-monooxygenase from Aspergillus fumigatus is a flavin monooxygenase that catalyzes the NADPH-dependent hydroxylation of ornithine. Herein we report a mutagenesis study targeting four residues that contact ornithine in crystal structures of SidA: Lys107, Asn293, Asn323, and Ser469.
Insaf Ahmed Qureshi, John Tanner, Catherine Klancher   +2 more
exaly   +4 more sources

Hypoxia-Associated Remodeling of the Arginine–Citrulline–Ornithine Axis in Parkinson’s Disease and Restless Legs Syndrome: A Targeted LC–MS/MS and HIF-1α Profiling Study [PDF]

Medicina
Background and Objectives: Hypoxia-inducible factor-1 alpha (HIF-1α) is a central regulator of cellular responses to hypoxia and has been implicated in the pathophysiology of several neurological disorders.
Seyma Dumur, Mohammad Mahdi Bagheri Asl, Demet Aygun, Hafize Boyaci, Dildar Konukoglu, Hafize Uzun   +5 more
doaj   +2 more sources

Dysregulation of the urea cycle – potential targets for treatment and diagnosis in prostate cancer [PDF]

Expert Reviews in Molecular Medicine
Background Prostate cancer (PCa) exhibits profound metabolic reprogramming, including dysregulation of the urea cycle (UC), an emerging driver of tumour growth, therapy resistance, and immune modulation.
Michael Ladurner, Helmut Klocker, Hannes Neuwirt, Iris E. Eder   +3 more
doaj   +2 more sources

Ornithine Aminotransferase, an Important Glutamate-Metabolizing Enzyme at the Crossroads of Multiple Metabolic Pathways

Biology, 2017
Ornithine δ-aminotransferase (OAT, E.C. 2.6.1.13) catalyzes the transfer of the δ-amino group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and glutamate (Glu), and vice versa. In mammals, OAT is a mitochondrial enzyme,
Ioannis Nicolis, Emmanuel Curis, Antonin Ginguay   +2 more
exaly   +3 more sources

Alterations in Arginase Activity and Polyamine Metabolism Contribute to the Mode of Action of Canavanine in Tomato Roots [PDF]

Biology
Canavanine (CAN) is a nonproteinogenic amino acid, synthesised by many legumes (e.g., alfalfa, hairy vetch) and acts as a strong inhibitor of root growth.
Pawel Staszek, Katarzyna Ciacka, Agnieszka Gniazdowska   +2 more
doaj   +2 more sources

The reaction of ornithine aminotransferase with ornithine [PDF]

Biochemical Journal, 1982
Rat liver ornithine aminotransferase is found to exchange the pro-S hydrogen on the delta-carbon atom of ornithine exclusively, thus showing that the mammalian enzyme transfers the delta-amino group and not the alpha-amino group as has been demonstrated with the plant enzyme [Mestichelli, Gupta & Spenser (1979) J. Biol. Chem. 254, 640-647].
J A, Williams, G, Bridge, L J, Fowler, R A, John   +3 more
openaire   +2 more sources

Urea Cycle and Arginine Metabolic Changes in COVID-19 Patients

Eurasian Journal of Emergency Medicine, 2023
Aim:Metabolic changes begin after the invasion of an infectious microorganism and continue to develop as a series of interrelated events. Arginine is important in infectious diseases due to lymphocyte proliferation, nitricoxide production by macrophages,
Sedat Özbay, Hüseyin Aydın, İlhan Korkmaz, Yusuf Kenan Tekin, Gülacan Tekin, Sefa Yurtbay, Ata Berkay Sargın, Nezih Hekim   +7 more
doaj   +1 more source

Plasma urea cycle metabolite levels and the risk of moyamoya disease

Frontiers in Neuroscience, 2023
Background and purposeUrea cycle metabolites are expected to be the biomarkers for cerebrovascular diseases. However, the effects of circulating urea cycle metabolites on the risk of MMD and its subcategories remain unclear.
Xiaofan Yu, Xiaofan Yu, Xiaofan Yu, Xiaofan Yu, Xiaofan Yu, Peicong Ge, Peicong Ge, Peicong Ge, Peicong Ge, Peicong Ge, Yuanren Zhai, Yuanren Zhai, Yuanren Zhai, Yuanren Zhai, Yuanren Zhai, Wei Liu, Wei Liu, Wei Liu, Wei Liu, Wei Liu, Qian Zhang, Qian Zhang, Qian Zhang, Qian Zhang, Qian Zhang, Xun Ye, Xun Ye, Xun Ye, Xun Ye, Xun Ye, Xingju Liu, Xingju Liu, Xingju Liu, Xingju Liu, Xingju Liu, Rong Wang, Rong Wang, Rong Wang, Rong Wang, Rong Wang, Yan Zhang, Yan Zhang, Yan Zhang, Yan Zhang, Yan Zhang, Jizong Zhao, Jizong Zhao, Jizong Zhao, Jizong Zhao, Jizong Zhao, Jizong Zhao, Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang, Dong Zhang   +56 more
doaj   +1 more source

Fatty Acyl Esters of Hydroxy Fatty Acid (FAHFA) Lipid Families

Metabolites, 2020
Fatty Acyl esters of Hydroxy Fatty Acids (FAHFA) encompass three different lipid families which have incorrectly been classified as wax esters. These families include (i) Branched-chain FAHFAs, involved in the regulation of glucose metabolism and ...
Paul L. Wood
doaj   +1 more source

The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium

Metabolites, 2022
The mechanisms underlying the occurrence of postoperative delirium development are unclear and measurement of plasma metabolites may improve understanding of its causes.
Mijin Jung, Xiaobei Pan, Emma L. Cunningham, Anthony P. Passmore, Bernadette McGuinness, Daniel F. McAuley, David Beverland, Seamus O’Brien, Tim Mawhinney, Jonathan M. Schott, Henrik Zetterberg, Brian D. Green   +11 more
doaj   +1 more source