Results 21 to 30 of about 87,049 (284)

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei [PDF]

, 2012
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides.
Burgess, K., Burchmore, Richard J S, Barrett, M.P., Creek, D.J., Vincent, I.M., Woods, Debra, Karl Burgess, Richard J S Burchmore, Woods, Debra J, Creek, Darren, Debra J. Woods (167740), Creek, Darren John, Isabel M Vincent, Vincent, Isabel M, Michael P Barrett, Darren J. Creek (167726), Woods, D.J., Isabel M. Vincent (167717), Woods Debra J., Burgess Karl, Burgess, Karl, Burchmore, Richard, Barrett, Michael P, Vincent, Isabel, Barrett Michael P., Burchmore, R.J.S., Creek Darren J., Richard J. S. Burchmore (167742), Vincent Isabel M., Darren J Creek, Karl Burgess (167732), Debra J Woods, Barrett, Michael, Michael P. Barrett (167748), Burchmore Richard J. S.   +34 more
core   +1 more source

A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model

Antioxidants, 2022
The currently available management strategies for acute pancreatitis are inadequately effective which calls for exploration of new approaches to treat this condition.
Nancy Nabil Shahin, Rehab Nabil Shamma, Iman Saad Ahmed   +2 more
doaj   +1 more source

Characterization of High-Ornithine-Producing Weissella koreensis DB1 Isolated from Kimchi and Its Application in Rice Bran Fermentation as a Starter Culture

Foods, 2020
High-ornithine-producing Weissella koreensis DB1 were isolated from kimchi. Ornithine is produced from arginine via the intracellular arginine deiminase pathway in microorganisms; thus, high cell growth is important for producing ornithine in large ...
Mun So Yeong, Moon Song Hee, Chang Hae Choon   +2 more
doaj   +1 more source

Arginine and Polyamines Fate in Leishmania Infection

Frontiers in Microbiology, 2018
Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian host macrophages, involving several environmental changes.
Sandra M. Muxel, Juliana I. Aoki, Juliane C. R. Fernandes, Maria F. Laranjeira-Silva, Ricardo A. Zampieri, Stephanie M. Acuña, Karl E. Müller, Rubia H. Vanderlinde, Lucile M. Floeter-Winter   +8 more
doaj   +1 more source

Supplementation of L-Ornithine Could Increase Sleep-like Behavior in the Mouse Pups

Metabolites, 2022
Along the maternal–fetal–neonatal axis, one of the problems relating to the maternal–neonatal axis is infant sleep problems including nighttime crying. One possible solution could be to provide the newborn with sleep-promoting ingredients through breast ...
Mayumi Takakura, Satsuki Nagamachi, Takuma Nishigawa, Yoshihiro Takahashi, Mitsuhiro Furuse   +4 more
doaj   +1 more source

A shotgun lipidomics approach in Sinorhizobium meliloti as a tool in functional genomics

Journal of Lipid Research, 2009
A shotgun lipidomics approach that allowed the analysis of eight lipid classes directly from crude extracts of the soil bacterium Sinorhizobium meliloti is presented.
Libia Saborido Basconcillo, Rahat Zaheer, Turlough M. Finan, Brian E. McCarry   +3 more
doaj   +1 more source

Changes in Uterine Metabolome Associated with Metritis Development and Cure in Lactating Holstein Cows

Metabolites, 2023
The objective of this study was to identify alterations in the vaginal discharge (VD) metabolome and potential biomarkers to predict metritis development and a cure in dairy cows.
Eduardo B. de Oliveira, Hugo F. Monteiro, Jessica M. V. Pereira, Deniece R. Williams, Richard V. Pereira, Noelia Silva Del Rio, Paulo R. Menta, Vinicius S. Machado, Fabio S. Lima   +8 more
doaj   +1 more source

Involvement of Spermidine in the Reduced Lifespan of Caenorhabditis elegans During Vitamin B₁₂ Deficiency

Metabolites, 2019
Vitamin B12 deficiency leads to various symptoms such as neuropathy, growth retardation, and infertility. Vitamin B12 functions as a coenzyme for two enzymes involved in amino acid metabolisms.
Tomohiro Bito, Naho Okamoto, Kenji Otsuka, Yukinori Yabuta, Jiro Arima, Tsuyoshi Kawano, Fumio Watanabe   +6 more
doaj   +1 more source

Acupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine

Frontiers in Oncology, 2021
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending
Mengying Ke, Mengying Ke, Jinjun Qian, Feng Hao, Xinying Li, Hongjie Wu, Xian Luo, Bin Xu, Bin Xu, Chunyan Gu, Chunyan Gu, Ye Yang   +11 more
doaj   +1 more source

Channeling of extramitochondrial ornithine to matrix ornithine transcarbamylase.

Journal of Biological Chemistry, 1987
In the presence of citrulline synthesis, we made the following observations. External ornithine is channeled between its transporter and ornithine transcarbamylase; mitochondria preloaded with cold ornithine, then incubated with [3H]ornithine, produced citrulline of the same specific radioactivity as that of external ornithine, while matrix ornithine ...
N S, Cohen, C W, Cheung, L, Raijman
openaire   +2 more sources