Results 21 to 30 of about 81,019 (308)

Arginine and Polyamines Fate in Leishmania Infection

open access: yesFrontiers in Microbiology, 2018
Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the mammalian host macrophages, involving several environmental changes.
Sandra M. Muxel   +8 more
doaj   +1 more source

Supplementation of L-Ornithine Could Increase Sleep-like Behavior in the Mouse Pups

open access: yesMetabolites, 2022
Along the maternal–fetal–neonatal axis, one of the problems relating to the maternal–neonatal axis is infant sleep problems including nighttime crying. One possible solution could be to provide the newborn with sleep-promoting ingredients through breast ...
Mayumi Takakura   +4 more
doaj   +1 more source

Changes in Uterine Metabolome Associated with Metritis Development and Cure in Lactating Holstein Cows

open access: yesMetabolites, 2023
The objective of this study was to identify alterations in the vaginal discharge (VD) metabolome and potential biomarkers to predict metritis development and a cure in dairy cows.
Eduardo B. de Oliveira   +8 more
doaj   +1 more source

Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei. [PDF]

open access: yes, 2017
Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Indeed, ODC is the target of the WHO "essential medicine" eflornithine, which
Currier, Rachel B.   +15 more
core   +1 more source

A shotgun lipidomics approach in Sinorhizobium meliloti as a tool in functional genomics

open access: yesJournal of Lipid Research, 2009
A shotgun lipidomics approach that allowed the analysis of eight lipid classes directly from crude extracts of the soil bacterium Sinorhizobium meliloti is presented.
Libia Saborido Basconcillo   +3 more
doaj   +1 more source

Involvement of Spermidine in the Reduced Lifespan of Caenorhabditis elegans During Vitamin B12 Deficiency

open access: yesMetabolites, 2019
Vitamin B12 deficiency leads to various symptoms such as neuropathy, growth retardation, and infertility. Vitamin B12 functions as a coenzyme for two enzymes involved in amino acid metabolisms.
Tomohiro Bito   +6 more
doaj   +1 more source

Acupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine

open access: yesFrontiers in Oncology, 2021
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending
Mengying Ke   +11 more
doaj   +1 more source

Ornithine Utilization by the Chick

open access: yesExperimental Biology and Medicine, 1971
SummaryAssays employing a chemically defined diet were conducted to determine if the young chick could utilize dietary ornithine. A plasma assay and a tracer study clearly demonstrated that the chick can both absorb and metabolize ornithine. Moreover, a significant quantity of 14C from injected ornithine-U-14C was recovered in liver protein as proline ...
G, Graber, D H, Baker
openaire   +2 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

open access: yesHepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong   +9 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

open access: yesHepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli   +13 more
wiley   +1 more source

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