Results 31 to 40 of about 81,019 (308)

Regulation of Ornithine Decarboxylase [PDF]

Journal of Biological Chemistry, 2006
Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. The amount of ODC is altered in response to many growth factors, oncogenes, and tumor promoters and to changes in polyamine levels. Susceptibility to tumor development is increased in transgenic mice expressing high levels of ODC and is decreased in mice with reduced ODC due to
openaire   +2 more sources

Ornithine carbamyl transferase in Reye's syndrome [PDF]

, 1984
Serum levels of ornithine carbamyl transferase activities were determined in the acutely ill and convalescent Reye's syndrome patients and in their parents.
Remington, Patrick L., Deshmukh, Devendra R.   +1 more
core   +1 more source

Synthesis of a Borrelia burgdorferi-Derived Muropeptide Standard Fragment Library

Molecules
The interplay between the human innate immune system and bacterial cell wall components is pivotal in understanding diseases such as Crohn’s disease and Lyme arthritis.
Rachel Putnik, Junhui Zhou, Irnov Irnov, Elise Garner, Min Liu, Klare L. Bersch, Christine Jacobs-Wagner, Catherine Leimkuhler Grimes   +7 more
doaj   +1 more source

Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast

Microbial Cell, 2015
Impaired protein degradation and mitochondrial dysfunction are believed to contribute to neurodegenerative disorders, including Alzheimer disease (AD). In patients suffering from non-hereditary AD, UBB+1, the frameshift variant of ubiquitin B,
Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo   +15 more
doaj   +1 more source

Maternal Supplementation with Ornithine Promotes Placental Angiogenesis and Improves Intestinal Development of Suckling Piglets

Animals
The blood vessels of the placenta are crucial for fetal growth. Here, lower vessel density and ornithine (Orn) content were observed in placentae for low-birth-weight fetuses versus normal-birth-weight fetuses at day 75 of gestation. Furthermore, the Orn
Yun Yang, Guanyu Hou, Fengjie Ji, Hanlin Zhou, Renlong Lv, Chengjun Hu   +5 more
doaj   +1 more source

Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome

, 2015
Ornithine decarboxylase (ODC), a ubiquitin-independent substrate of the proteasome, is a homodimeric protein with a rate-limiting function in polyamine biosynthesis.
R. Jürgen Dohmen, Daniela Gödderz, R. Roshini Beenukumar, R. Palanimurugan   +3 more
core   +1 more source

Bipolar Membrane Electrodialysis for Direct Conversion of L-Ornithine Monohydrochloride to L-Ornithine

, 2023
In this study, bipolar membrane electrodialysis was proposed to directly convert L-ornithine monohydrochloride to L-ornithine. The stack configuration was optimized in the BP-A (BP, bipolar membrane; A, anion exchange membrane) configuration with the Cl ...
Zhiyi Zheng, Jianrong Hao, Yuxin Liang, Haiyang Yan, Jinfeng He, Wenlong Liu, Chuanrun Li, Xixi Ma, Zhihao Tian, Li Sun, Yinghan Fang   +10 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine

eLife
The concept of ‘kokumi’, which refers to an enhanced and more delicious flavor of food, has recently generated considerable interest in food science. However, kokumi has not been well studied in gustatory physiology, and the underlying neuroscientific ...
Takashi Yamamoto, Kayoko Ueji, Haruno Mizuta, Chizuko Inui-Yamamoto, Natsuko Kumamoto, Yasuhiro Shibata, Shinya Ugawa   +6 more
doaj   +1 more source

Behind anticancer molecules: lactoferricin dimeric peptides with fast, selective, persistent and broad-spectrum cytotoxic effect [PDF]

Exploration of Drug Science
Aim: To identify peptides derived from bovine lactoferricin (LfcinB) as potential therapeutics for colon cancer treatment. We systematically modified dimeric peptides to enhance their selectivity against colon cancer cells and reduce toxicity.
Karen Johanna Cárdenas-Martínez, Juan Esteban Reyes-Calderon, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cárdenas, Ricardo Fierro-Medina, Joel E. Lopez-Meza, Luis Fernando Ospina-Giraldo, Zuly Jenny Rivera-Monroy, Javier Eduardo García-Castañeda   +9 more
doaj   +1 more source