Results 51 to 60 of about 87,049 (284)

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Fermentation in Pineapple Juice Significantly Enhances Ornithine and Citrulline Production in Lactococcus lactis MSC-3G Isolated from Sugarcane

Microorganisms, 2022
Lactic acid bacterial (LAB) fermentation of functional amino acids using fruit juices as a cultivation medium is not well-documented. In the present study, we successfully isolated a high ornithine- and citrulline-producing Lactococcus lactis strain ...
Yusuke Inoue, Narandalai Danshiitsoodol, Masafumi Noda, Katsushi Hagihara, Masanori Sugiyama   +4 more
doaj   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Some Important Metabolites Produced by Lactic Acid Bacteria Originated from Kimchi

Foods, 2021
Lactic acid bacteria (LAB) have been used for various food fermentations for thousands of years. Recently, LAB are receiving increased attention due to their great potential as probiotics for man and animals, and also as cell factories for producing ...
Se-Jin Lee, Hye-Sung Jeon, Ji-Yeon Yoo, Jeong-Hwan Kim   +3 more
doaj   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Influence of arginine metabolites on human tumor cell viability upon arginine deprivation in vitro

Біологічні студії, 2011
In human organism arginine is necessary not only for protein synthesis but it also serves as a precursor for a number of important biologically active substances that influence cell growth and viability. These substances include such arginine metabolites
Y. V. Kurlishchuk, B. O. Vynnytska-Myronovska, Y. P. Bobak, O. V. Stasyk   +3 more
doaj   +1 more source

Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei. [PDF]

, 2017
Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Indeed, ODC is the target of the WHO "essential medicine" eflornithine, which
Currier, Rachel B., Wirdnam, Corina, Horn, David, Sam Alsford, Alsford, Sam, Corina Wirdnam, Macedo, Juan P., Juan P. Macedo, Pereira de Macêdo, Juan, Currier, Rachel B, Horn, David; id_orcid, Rachel B. Currier, Macedo, Juan P, Doris Rentsch, David Horn, Rentsch, Doris   +15 more
core   +2 more sources

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

Angewandte Chemie, EarlyView.
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran, Axia Marlin, Edith K. Amason, Marie Huynh, Hannah Carlisle, Eszter Boros   +5 more
wiley   +2 more sources