Results 51 to 60 of about 70,919 (240)

Influence of arginine metabolites on human tumor cell viability upon arginine deprivation in vitro

Біологічні студії, 2011
In human organism arginine is necessary not only for protein synthesis but it also serves as a precursor for a number of important biologically active substances that influence cell growth and viability. These substances include such arginine metabolites
Y. V. Kurlishchuk, B. O. Vynnytska-Myronovska, Y. P. Bobak, O. V. Stasyk   +3 more
doaj   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Impaired arginine/ornithine metabolism drives severe HFMD by promoting cytokine storm

Frontiers in Immunology
IntroductionThe Hand, Foot and Mouth Disease (HFMD), caused by enterovirus 71 infection, is a global public health emergency. Severe HFMD poses a significant threat to the life and well-being of children.
Yaozhong Zhang, Yaozhong Zhang, Yaozhong Zhang, Qingqing Yang, Qi Peng, Qi Peng, Qi Peng, Zhihua Tian, Fen Lv, Fen Lv, Fen Lv, Xiaomei Zeng, Xiaomei Zeng, Xiaomei Zeng, Zaixue Jiang, Zaixue Jiang, Zaixue Jiang, Qingqiu Cheng, Qingqiu Cheng, Qingqiu Cheng, Lijun Yang, Baimao Zhong, Baimao Zhong, Baimao Zhong, Xiaomei Lu, Xiaomei Lu, Xiaomei Lu, Yinghua Zhu, Yinghua Zhu, Yinghua Zhu   +29 more
doaj   +1 more source

Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels—A Randomized, Double-Blind, Placebo-Controlled Trial

Marine Drugs, 2018
Aging-associated changes of skin conditions are a major concern for maintaining quality of life. Therefore, the improvement of skin conditions by dietary supplementation is a topic of public interest.
Naoki Ito, Shinobu Seki, Fumitaka Ueda
doaj   +1 more source

A Supramolecular Approach to Structure-Based Design with A Focus on Synthons Hierarchy in Ornithine-Derived Ligands: Review, Synthesis, Experimental and in Silico Studies

Molecules, 2020
The success of innovative drugs depends on an interdisciplinary and holistic approach to their design and development. The supramolecular architecture of living systems is controlled by non-covalent interactions to a very large extent.
Joanna Bojarska, Milan Remko, Martin Breza, Izabela D. Madura, Krzysztof Kaczmarek, Janusz Zabrocki, Wojciech M. Wolf   +6 more
doaj   +1 more source

Gyrate atrophy-like phenotype with normal plasma ornithine and low plasma taurine

GMS Ophthalmology Cases, 2020
We present the case of a 39-year-old male with sectoral chorioretinal atrophy similar to that seen in gyrate atrophy (GA) but with a normal plasma ornithine level. Unlike previously reported cases of GA, he had below-normal plasma taurine concentration.
Labiano, Aubhugn T., Arroyo, Milagros H.
doaj   +1 more source

Ornithine Decarboxylase in Skin

Journal of Investigative Dermatology, 1980
Ornithine decarboxylase (ODC) was discovered in animal tissues in 1968 [1,2] and interest in its activity and regulation has led to a rapidly and still expanding literature on the enzyme. Several comprehensive reviews have already appeared [3–6]. This article emphasizes our current knowledge of ODC in mammalian skin.
Lesiewicz, Jeanne, Goldsmith, Lowell A.
openaire   +2 more sources

Pseudomonas aeruginosa alkyl quinolone response is dampened by Enterococcus faecalis

mBio
The bacterium Pseudomonas aeruginosa is an opportunistic pathogen that can cause lung, skin, wound, joint, urinary tract, and eye infections. While P.
Maggie M. Fink, Abigail A. Weaver, Dharmeshkumar Parmar, Jon E. Paczkowski, Lingyun Li, Maggie K. Klaers, Ella A. Junker, Elizabeth A. Jarocki, Jonathan V. Sweedler, Joshua D. Shrout   +9 more
doaj   +1 more source

Effect of Rosuvastatin on Arginase Enzyme Activity and Polyamine Production in Experimental Breast Cancer

Balkan Medical Journal, 2015
Background: Breast cancer is the most common malignant tumour of women around the world. As a key enzyme of the urea cycle, arginase leads to the formation of urea and ornithine from L-arginine.
Hakan Erbaş, Oğuz Bal, Erol Çakır
doaj   +1 more source

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, EarlyView.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source