Results 71 to 80 of about 87,049 (284)

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Pseudomonas aeruginosa alkyl quinolone response is dampened by Enterococcus faecalis

mBio
The bacterium Pseudomonas aeruginosa is an opportunistic pathogen that can cause lung, skin, wound, joint, urinary tract, and eye infections. While P.
Maggie M. Fink, Abigail A. Weaver, Dharmeshkumar Parmar, Jon E. Paczkowski, Lingyun Li, Maggie K. Klaers, Ella A. Junker, Elizabeth A. Jarocki, Jonathan V. Sweedler, Joshua D. Shrout   +9 more
doaj   +1 more source

L-Aspartate, L-Ornithine and L-Ornithine-L-Aspartate (LOLA) and Their Impact on Brain Energy Metabolism [PDF]

, 2020
L-Ornithine-L-aspartate (LOLA), a crystalline salt, is used primarily in the management of hepatic encephalopathy. The degree to which it might penetrate the brain, and the effects it might have on metabolism in brain are poorly understood.
Das, A ; https://orcid.org/, Rae, CD ; https://orcid.org/, Rowlands, BD, Housley, GD ; https://orcid.org/, Froehlich, Dominik ; https://orcid.org/, Fröhlich, D, Achanta, LB ; https://orcid.org/, Klugmann, M ; https://orcid.org/   +7 more
core   +1 more source

Effect of Rosuvastatin on Arginase Enzyme Activity and Polyamine Production in Experimental Breast Cancer

Balkan Medical Journal, 2015
Background: Breast cancer is the most common malignant tumour of women around the world. As a key enzyme of the urea cycle, arginase leads to the formation of urea and ornithine from L-arginine.
Hakan Erbaş, Oğuz Bal, Erol Çakır
doaj   +1 more source

Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine

, 2015
Baker’s yeast Saccharomyces cerevisiae is an attractive cell factory for production of chemicals and biofuels. Many different products have been produced in this cell factory by reconstruction of heterologous biosynthetic pathways; however, endogenous ...
Y. Zhou (1947760), Lifang Liu (23334334), B. Jiang (752763), M. Huang (7782647), V. Siewers (23361166), S. Khoomrung (23361163), A. Krivoruchko (23361160), J. Qin (2415235), J. Nielsen (19003772)   +8 more
core  

Acetyl-ornithine transaminase in Neurospora [PDF]

, 1965
Acetyl-ornithine transaminase in ...
Morgan, D. H., D. H. Morgan
core   +1 more source

Synthesis of 2-(nitromethyl)ornithine from ornithine mediated by cobalt(III).

, 2015
Rac.-p-(tris(2-aminoethyl)amine-2-(nitromethyl)ornithine)cobalt(III) trichloride (2d) was obtained by a simple three-step procedure from ornithine using cobalt template chemistry.
Hammershoi, Anders, Sargeson, Alan, Golding, Bernard, Crane, Christopher, Hockless, David, Butler, Philip, Petersen, Tue, Ward, Stephen A   +7 more
core   +1 more source

Hepatic encephalopathy syndrome: current aspects of diagnosis and treatment

Медицинский совет, 2016
Chronic liver diseases (CKD) are located on one of the first places on the incidence and are currently the fifth most common cause of mortality in many developed countries. One of the manifestations caused by hepatic insufficiency, hepatic encephalopathy
D. I. Trukhan
doaj   +1 more source