Results 61 to 70 of about 87,049 (284)
Impaired arginine/ornithine metabolism drives severe HFMD by promoting cytokine storm
Frontiers in ImmunologyIntroductionThe Hand, Foot and Mouth Disease (HFMD), caused by enterovirus 71 infection, is a global public health emergency. Severe HFMD poses a significant threat to the life and well-being of children.
Yaozhong Zhang +29 more
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Marine Drugs, 2018 Aging-associated changes of skin conditions are a major concern for maintaining quality of life. Therefore, the improvement of skin conditions by dietary supplementation is a topic of public interest.
Naoki Ito, Shinobu Seki, Fumitaka Ueda
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Molecules, 2020 The success of innovative drugs depends on an interdisciplinary and holistic approach to their design and development. The supramolecular architecture of living systems is controlled by non-covalent interactions to a very large extent.
Joanna Bojarska +6 more
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TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis
Advanced Science, EarlyView.A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu +12 more
wiley +1 more source
Gyrate atrophy-like phenotype with normal plasma ornithine and low plasma taurine
GMS Ophthalmology Cases, 2020 We present the case of a 39-year-old male with sectoral chorioretinal atrophy similar to that seen in gyrate atrophy (GA) but with a normal plasma ornithine level. Unlike previously reported cases of GA, he had below-normal plasma taurine concentration.
Labiano, Aubhugn T., Arroyo, Milagros H.
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Advanced Science, EarlyView.This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun +7 more
wiley +1 more source
Structure and Function of Ornithine Carbamoyltransferases [PDF]
European Journal of Biochemistry, 1977 The reaction catalyzed by ornithine carbamoyltransferase can participate in either the anabolism or the catabolism of arginine. The carbamoylation of ornithine, yielding citrulline, is involved in the biosynthetic sequences; the reverse reaction, the phosphorolysis of citrulline, is the second step of the arginine deiminase pathway.The ornithine ...
Legrain, Christiane +6 more
openaire +3 more sources
Advanced Science, EarlyView.This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang +5 more
wiley +1 more source
Ornithine Decarboxylase in Skin
Journal of Investigative Dermatology, 1980 Ornithine decarboxylase (ODC) was discovered in animal tissues in 1968 [1,2] and interest in its activity and regulation has led to a rapidly and still expanding literature on the enzyme. Several comprehensive reviews have already appeared [3–6]. This article emphasizes our current knowledge of ODC in mammalian skin.
Lesiewicz, Jeanne, Goldsmith, Lowell A.
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Ornithine carbamyl transferase in Reye's syndrome [PDF]
, 1984 Serum levels of ornithine carbamyl transferase activities were determined in the acutely ill and convalescent Reye's syndrome patients and in their parents.
Remington, Patrick L. +1 more
core +1 more source