Results 61 to 70 of about 81,019 (308)

Gyrate atrophy-like phenotype with normal plasma ornithine and low plasma taurine

GMS Ophthalmology Cases, 2020
We present the case of a 39-year-old male with sectoral chorioretinal atrophy similar to that seen in gyrate atrophy (GA) but with a normal plasma ornithine level. Unlike previously reported cases of GA, he had below-normal plasma taurine concentration.
Labiano, Aubhugn T., Arroyo, Milagros H.
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Structure and Function of Ornithine Carbamoyltransferases [PDF]

European Journal of Biochemistry, 1977
The reaction catalyzed by ornithine carbamoyltransferase can participate in either the anabolism or the catabolism of arginine. The carbamoylation of ornithine, yielding citrulline, is involved in the biosynthetic sequences; the reverse reaction, the phosphorolysis of citrulline, is the second step of the arginine deiminase pathway.The ornithine ...
Legrain, Christiane, Stalon, Victor, Noullez, Jean Pierre, Mercenier, Annick, Simon, Jean-Paul, Broman, Kathleen, Wiame, Jean-Marie   +6 more
openaire   +3 more sources

Binding model of L-ornithine bound to human mitochondrial ornithine transporter-1.

, 2013
(A) Lateral view of the ornithine binding interactions, where the backbone of human mitochondrial ornithine transporter-1 is colored in coffee, while the ligand L-ornithine in green.
Kuo-Chen Chou (117713), Jing-Fang Wang (124815)   +1 more
core   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Comparative chemoreactomic analysis of ornithine aspartate, S-ademethionine and ursodeoxycholic acid

Фармакокинетика и Фармакодинамика, 2022
Purpose of the study. The pharmacological effects of ornithine are primarily due to its participation in the neutralization of ammonia and in the metabolism of amino acids.
I. Yu. Torshin, O. A. Gromova
doaj   +1 more source

Spectrophotometric assay for ornithine decarboxylase [PDF]

, 1987
A rapid and sensitive spectrophotometric assay for ornithine decarboxylase is described. It is based on the observation that the product of ornithine decarboxylase, putrescine, reacts with 2,4,6-trinitrobenzenesulfonic acid to give a colored product ...
Phan, Andrew PH, Ngo, That T, Lenhoff, Howard M, Davis, Rowland H, Bovaird, Jack H, Marsh, J Lawrence, Wong, Raphael C, Brillhart, Kurt L, Digangi, Joseph J, Ristow, Janet L   +9 more
core   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Ornithine Decarboxylase in Skin

Journal of Investigative Dermatology, 1980
Ornithine decarboxylase (ODC) was discovered in animal tissues in 1968 [1,2] and interest in its activity and regulation has led to a rapidly and still expanding literature on the enzyme. Several comprehensive reviews have already appeared [3–6]. This article emphasizes our current knowledge of ODC in mammalian skin.
Lesiewicz, Jeanne, Goldsmith, Lowell A.
openaire   +2 more sources

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source