Results 41 to 50 of about 70,919 (240)
Behind anticancer molecules: lactoferricin dimeric peptides with fast, selective, persistent and broad-spectrum cytotoxic effect [PDF]
Exploration of Drug ScienceAim: To identify peptides derived from bovine lactoferricin (LfcinB) as potential therapeutics for colon cancer treatment. We systematically modified dimeric peptides to enhance their selectivity against colon cancer cells and reduce toxicity.
Karen Johanna Cárdenas-Martínez +9 more
doaj +1 more source
Advanced Materials, EarlyView.Oxygen‐releasing hydrogels are widely used to support cell survival in 3D cultures and to promote wound healing. However, incorporating catalase to convert H2O2 into O2 often generates additional oxygen bubbles, leading to material instability which rarely addressed.
Sukulya Bunuasunthon +3 more
wiley +1 more source
Channeling of extramitochondrial ornithine to matrix ornithine transcarbamylase.
Journal of Biological Chemistry, 1987 In the presence of citrulline synthesis, we made the following observations. External ornithine is channeled between its transporter and ornithine transcarbamylase; mitochondria preloaded with cold ornithine, then incubated with [3H]ornithine, produced citrulline of the same specific radioactivity as that of external ornithine, while matrix ornithine ...
N S, Cohen, C W, Cheung, L, Raijman
openaire +2 more sources
Advanced Materials Technologies, EarlyView.Nanoporous silica nanoparticles incorporated in nanoporous platinum offer the possibility for implant‐associated drug delivery from neuronal electrodes. ABSTRACT Sensorineural hearing loss, resulting from damage to the hair cells of the inner ear, profoundly impairs quality of life.
Mosaieb Habib +10 more
wiley +1 more source
Microorganisms, 2022 Lactic acid bacterial (LAB) fermentation of functional amino acids using fruit juices as a cultivation medium is not well-documented. In the present study, we successfully isolated a high ornithine- and citrulline-producing Lactococcus lactis strain ...
Yusuke Inoue +4 more
doaj +1 more source
Advanced Science, EarlyView.Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng +17 more
wiley +1 more source
Dysregulation of the urea cycle – potential targets for treatment and diagnosis in prostate cancer
Expert Reviews in Molecular MedicineBackground Prostate cancer (PCa) exhibits profound metabolic reprogramming, including dysregulation of the urea cycle (UC), an emerging driver of tumour growth, therapy resistance, and immune modulation.
Michael Ladurner +3 more
doaj +1 more source
Some Important Metabolites Produced by Lactic Acid Bacteria Originated from Kimchi
Foods, 2021 Lactic acid bacteria (LAB) have been used for various food fermentations for thousands of years. Recently, LAB are receiving increased attention due to their great potential as probiotics for man and animals, and also as cell factories for producing ...
Se-Jin Lee +3 more
doaj +1 more source
Structure and Function of Ornithine Carbamoyltransferases [PDF]
European Journal of Biochemistry, 1977 The reaction catalyzed by ornithine carbamoyltransferase can participate in either the anabolism or the catabolism of arginine. The carbamoylation of ornithine, yielding citrulline, is involved in the biosynthetic sequences; the reverse reaction, the phosphorolysis of citrulline, is the second step of the arginine deiminase pathway.The ornithine ...
Legrain, Christiane +6 more
openaire +3 more sources
Advanced Science, EarlyView.A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li +9 more
wiley +1 more source