Results 1 to 10 of about 37,088 (271)

Enhancement of fracture healing after citrulline supplementation in mice [PDF]

European Cells & Materials, 2020
Around 10 % of long bone fractures show inadequate bone healing resulting in non-union development. A deregulated arginine-citrulline-nitric oxide metabolism caused by a poor nutritional status of the patients is a risk factor for non-unions ...
DM Meesters, PFW Hannemann,, HMH van Eijk, VTJ Schriebl, PRG Brink, M Poeze, KAP Wijnands   +6 more
doaj   +3 more sources

Hypoxia-Associated Remodeling of the Arginine-Citrulline-Ornithine Axis in Parkinson's Disease and Restless Legs Syndrome: A Targeted LC-MS/MS and HIF-1α Profiling Study. [PDF]

Medicina (Kaunas)
Background and Objectives: Hypoxia-inducible factor-1 alpha (HIF-1α) is a central regulator of cellular responses to hypoxia and has been implicated in the pathophysiology of several neurological disorders.
Dumur S, Asl MMB, Aygun D, Boyaci H, Konukoglu D, Uzun H.   +5 more
europepmc   +2 more sources

A Four-Year Prospective Pilot Study of Newborn Screening for Late-Onset Proximal Urea-Cycle Disorders in Hyogo Prefecture in Japan. [PDF]

Int J Neonatal Screen
Proximal urea-cycle disorders (PUCDs), including N-acetylglutamate synthase deficiency (NAGSD), ornithine transcarbamylase deficiency (OTCD), and carbamoyl phosphate synthase 1 deficiency (CPS1D), cause hyperammonemia and impair neurological outcomes ...
Lee T, Matsui M, Yokoyama Y, Bo R, Awano H, Kataoka D, Ueda M, Minato T, Kobayashi H, Hasegawa Y, Murayama K, Takeshima Y.   +11 more
europepmc   +2 more sources

Maternal dietary citrulline supplementation increases fetal growth and programs pancreatic development in the lambs. [PDF]

Amino Acids
Intrauterine growth restriction (IUGR), caused by maternal undernutrition, impairs fetal growth and increases the risk for postnatal metabolic dysfunction.
Herring AB, Herron KS, Lemcke LG, Johnson GA, Satterfield MC.   +4 more
europepmc   +2 more sources

Rootstock mediates transcriptional regulation of citrulline metabolism in grafted watermelon [PDF]

Brazilian Journal of Biology, 2020
Citrulline is a non-essential amino acid, involved in key biological functions in plants and humans. Rootstocks have a major impact on citrulline accumulation in grafted watermelon. Information regarding rootstock induced changes in citrulline metabolism
A. Aslam, Z. Shengjie, L. Xuqiang, H. Nan, L. Wenge   +4 more
doaj   +1 more source

Citrulline Accumulation Mechanism of Pediococcus acidilactici and Weissella confusa in Soy Sauce and the Effects of Phenolic Compound on Citrulline Accumulation

Frontiers in Microbiology, 2021
Citrulline is one of the major precursors of ethyl carbamate in soy sauce, and the accumulation of citrulline is attributed to the metabolism of arginine by bacteria with the arginine deiminase (ADI) pathway.
Kai Zhou, Kai Zhou, Kai Zhou, Xiao Zhang, Bingyong Li, Chaoqun Shen, Yuan-Ming Sun, Jianyuan Yang, Zhen-Lin Xu   +8 more
doaj   +1 more source

Oral administration of l-citrulline alters the vascular delivery of substances to rat skeletal muscles

Biochemistry and Biophysics Reports, 2021
Vascular endothelial function deteriorates with age and disease, and the production of vasodilator factors like nitric oxide (NO) decreases. The free amino acid l-citrulline increases vasodilation and blood flow through increased NO production.
Sho Miyatake, Kazuo Hino, Goro Ebisu, Satoshi Fujita   +3 more
doaj   +1 more source

Impact of l‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells

Pulmonary Circulation, 2023
Impaired nitric oxide (NO) signaling contributes to the development of pulmonary hypertension (PH). The l‐arginine precursor, l‐citrulline, improves NO signaling and has therapeutic potential in PH.
Matthew S. Douglass, Mark R. Kaplowitz, Yongmei Zhang, Candice D. Fike   +3 more
doaj   +1 more source

Bioavailability of Citrulline in Watermelon Flesh, Rind, and Skin Using a Human Intestinal Epithelial Caco-2 Cell Model

Applied Sciences, 2023
Watermelon produces many byproducts (watermelon rind and skin) even though those components contain various bioactive compounds, including citrulline.
Inah Gu, Olugbenga Balogun, Cindi Brownmiller, Hye Won Kang, Sun-Ok Lee   +4 more
doaj   +1 more source

Modification of substrate specificity of l-arginine oxidase for detection of l-citrulline

AMB Express, 2023
Enzymatic detection of citrulline, a potential biomarker for various diseases, is beneficial. However, determining citrulline levels requires expensive instrumental analyses and complicated colorimetric assays. Although l-amino acid oxidase/dehydrogenase
Kei Yamamoto, Yosuke Masakari, Yasuko Araki, Atsushi Ichiyanagi, Kotaro Ito   +4 more
doaj   +1 more source