Journal of Pharmacological Sciences, 2015 l-Citrulline is an effective precursor of l-arginine produced by the l-citrulline/l-arginine cycle, and it exerts beneficial effects on the cardiovascular system by supporting enhanced nitric oxide (NO) production.
Asami Mori +5 more
doaj +1 more source
Citrulline inhibits LPS‐induced pyroptosis of RAW264.7 macrophages through NF‐κB signaling pathway
Immunity, Inflammation and Disease, 2023 Background The aim of this study was to investigate the effect of citrulline on the pyroptosis of mouse macrophage RAW264.7 and the mechanism. We investigated the effect of citrulline on pyroptosis of RAW264.7 cell induced by lipopolysaccharide (LPS ...
Li Yin +4 more
doaj +1 more source
Autophagy, citrullination and cancer [PDF]
Autophagy, 2016 A cell needs to maintain a balance between biosynthesis and degradation of cellular components to maintain homeostasis. There are 2 pathways, the proteasome, which degrades short-lived proteins, and the autophagy/lysosomal pathway, which degrades long-lived proteins and organelles. Both of these pathways are also involved in antigen presentation or the
Lindy G, Durrant +2 more
openaire +2 more sources
L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism. [PDF]
PLoS ONE, 2015 Dietary L-citrulline is thought to modulate muscle protein turnover by increasing L-arginine availability. To date, the direct effects of increased L-citrulline concentrations in muscle have been completely neglected. Therefore, we determined the role of
Daniel J Ham +6 more
doaj +1 more source
The effect of citrulline and citrulline malate supplementation on selected physiological indicators - review study [PDF]
, 2021 Title: The effect of citrulline and citrulline malate supplementation on selected physiological indicators - review study. Objectives: Systematic findings overview of the effect of citrulline and citrulline malate on healthy individual's locomotor system
Richter, Michael
core
Optimization of L-Citrulline Operon in Corynebacterium glutamicum for L-Citrulline Production
, 2022 L-citrulline plays important roles in many physiological processes, and its application range is expanding rapidly. Corynebacterium glutamicum strains have the potential to be efficient L-citrulline producers.
Zaiwei Man +4 more
core +1 more source
Sodium-coupled neutral amino acid transporter 1 (SNAT1) modulates L-citrulline transport and nitric oxide (NO) signaling in piglet pulmonary arterial endothelial cells. [PDF]
PLoS ONE, 2014 There is evidence that impairments in nitric oxide (NO) signaling contribute to chronic hypoxia-induced pulmonary hypertension. The L-arginine-NO precursor, L-citrulline, has been shown to ameliorate pulmonary hypertension.
Anna Dikalova +5 more
doaj +1 more source
Citrulline: from metabolism to therapeutic use.: citrulline: metabolism and therapeutic [PDF]
, 2013 International audienceCitrulline possesses a highly specific metabolism that bypasses splanchnic extraction because it is not used by the intestine or taken up by the liver.
Cynober, Luc +8 more
core +1 more source
Citrulline and intestinal fatty acid-binding protein as biomarkers for gastrointestinal dysfunction in the critically ill [PDF]
, 2019 Currently there is no reliable tool available to monitor gastrointestinal function in the critically ill. Biomarkers are therefore of great interest in this field as the lack of monitoring tools impedes any interventional studies.
Blaser, Annika +9 more
core +1 more source
Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome. [PDF]
PLoS ONE, 2013 In humans, plasma amino acid concentrations of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) increase in states of obesity, insulin resistance and diabetes.
Manuela Sailer +8 more
doaj +1 more source