Results 21 to 30 of about 34,707 (264)

Impact of l‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells

open access: yesPulmonary Circulation, 2023
Impaired nitric oxide (NO) signaling contributes to the development of pulmonary hypertension (PH). The l‐arginine precursor, l‐citrulline, improves NO signaling and has therapeutic potential in PH.
Matthew S. Douglass   +3 more
doaj   +1 more source

Bioavailability of Citrulline in Watermelon Flesh, Rind, and Skin Using a Human Intestinal Epithelial Caco-2 Cell Model

open access: yesApplied Sciences, 2023
Watermelon produces many byproducts (watermelon rind and skin) even though those components contain various bioactive compounds, including citrulline.
Inah Gu   +4 more
doaj   +1 more source

Optimization of L-Citrulline Operon in Corynebacterium glutamicum for L-Citrulline Production [PDF]

open access: yes, 2022
L-citrulline plays important roles in many physiological processes, and its application range is expanding rapidly. Corynebacterium glutamicum strains have the potential to be efficient L-citrulline producers.
Zaiwei Man   +4 more
core   +1 more source

Modification of substrate specificity of l-arginine oxidase for detection of l-citrulline

open access: yesAMB Express, 2023
Enzymatic detection of citrulline, a potential biomarker for various diseases, is beneficial. However, determining citrulline levels requires expensive instrumental analyses and complicated colorimetric assays. Although l-amino acid oxidase/dehydrogenase
Kei Yamamoto   +4 more
doaj   +1 more source

Binding Ability Studies of Arginine, Citrulline, N-Acetyl Citrulline and Thiocitrulline with SARS Cov-2 Main Protease Using Molecular Docking Studies [PDF]

open access: yes, 2020
To Editor in Chief Chemarxiv Respected Sir/Madam Subject: submission of preprint of an article to ChemRxiv on molecular docking studies of arginine and its structural analogues on COV-19 for publication.
Ramesh, Thimmasandra Narayan
core   +1 more source

Citrullination and Autophagy [PDF]

open access: yes, 2017
During evolution, the eukaryotic cells develop different processes in order to adapt themselves to environmental changes, as well as to die or to survive. These processes include apoptosis, NETosis, and autophagy: citrullination is implicated in all of these physiological mechanisms.
Guido Valesini   +5 more
openaire   +1 more source

Citrulline Recycling Supports Nitric Oxide Biosynthesis in Mouse PAM212 Keratinocytes [PDF]

open access: yes, 2021
Nitric oxide synthases generate nitric oxide and citrulline from arginine using NADPH and molecular oxygen as co-substrates. In most mammalian cells, arginine is an essential amino acid and limiting extracellular supplies of this amino acid can reduce ...
Heck, Diane E
core   +1 more source

L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells

open access: yesPulmonary Circulation, 2021
The L-arginine precursor, L-citrulline, re-couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Matthew S. Douglass   +3 more
doaj   +1 more source

Evaluation of the Utility of Amino Acid Citrulline as a Surrogate Metabolomic Biomarker for the Diagnosis of Celiac Disease

open access: yesNutrition and Metabolic Insights, 2021
Introduction: Citrulline is regarded as a biomarker for celiac disease (CD). Its utility for assessment and evaluation of additive predictive value for latent, potential CD and first degree relatives (FDRs) needs exploration.
Avinash Lomash   +9 more
doaj   +1 more source

Citrulline inhibits LPS‐induced pyroptosis of RAW264.7 macrophages through NF‐κB signaling pathway

open access: yesImmunity, Inflammation and Disease, 2023
Background The aim of this study was to investigate the effect of citrulline on the pyroptosis of mouse macrophage RAW264.7 and the mechanism. We investigated the effect of citrulline on pyroptosis of RAW264.7 cell induced by lipopolysaccharide (LPS ...
Li Yin   +4 more
doaj   +1 more source

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