Results 1 to 10 of about 25,677 (113)

Modification of substrate specificity of l-arginine oxidase for detection of l-citrulline [PDF]

AMB Express, 2023
Enzymatic detection of citrulline, a potential biomarker for various diseases, is beneficial. However, determining citrulline levels requires expensive instrumental analyses and complicated colorimetric assays. Although l-amino acid oxidase/dehydrogenase
Kei Yamamoto, Yosuke Masakari, Yasuko Araki, Atsushi Ichiyanagi, Kotaro Ito   +4 more
doaj   +2 more sources

L-Citrulline Improves Recovery of Enterocytes While Not Affecting Gut Microbiota in an In Vitro Model of Chemotherapy-Induced Gastrointestinal Mucositis [PDF]

Biomedicines
Background/Objectives: Despite significant advancements in cancer treatment outcomes, side effects, such as gastrointestinal mucositis (GIM), continue to impair patients’ quality of life.
Wally van der Laan, Pablo A. Gallardo Molina, Debby P. Y. Koonen, Hermie J. M. Harmsen, Wim J. E. Tissing   +4 more
doaj   +2 more sources

The effects of L-Citrulline and Glutathione on Endurance performance in young adult trained males [PDF]

Journal of the International Society of Sports Nutrition, 2023
Background Citrulline may amplify the effects of L-arginine and nitric oxide concentration, which may augment vasodilation and blood flow, thereby enhancing aerobic exercise performance.
Hannah E. Cabre, Casey E. Greenwalt, Lacey M. Gould, Abbie E. Smith-Ryan   +3 more
doaj   +2 more sources

Assessment of Registered Clinical Trial Designs: Comparison of L-Arginine and/or L-Citrulline Interventions for Hypertension [PDF]

Pharmaceuticals
Background: L-Arginine (Arg) is an essential amino acid and a precursor for the synthesis of vascular nitric oxide, while L-Citrulline is a non-essential amino acid substrate for increasing L-arginine.
Ashley Brett Hillsley, Craig Steven McLachlan   +1 more
doaj   +2 more sources

The Effects of L-Citrulline on the Apparent Digestion and Metabolism of Nutrients, Blood Hormone Levels, Amino Acid Metabolism and the Diversity of Faecal Microbiota in Mares in the Later Stage of Pregnancy [PDF]

Life
This study aimed to investigate the impact of dietary L-citrulline supplementation on the health of mares during late gestation. Thirty-two healthy mares in late pregnancy were randomly assigned to four groups: a control group (CON, 0 g/d) and three ...
Pengshun Liu, Fan Yang, Jiahao Li, Chao Li, Xinsheng Guo, Xiaobin Li   +5 more
doaj   +2 more sources

Impact of dietary supplementation of L-citrulline to meat goats during gestation on reproductive performance [PDF]

Journal of Animal Science and Biotechnology
Background Meat goat production is a worldwide industry with products such as meat, milk, soap, and fiber being produced. There are approximately 2.6 million meat goats in the United States.
Makenzie G. Newton, Arianna N. Lopez, Claire Stenhouse, Karina L. Hissen, Erin D. Connolly, Xingchi Li, Lan Zhou, Guoyao Wu, William B. Foxworth, Fuller W. Bazer   +9 more
doaj   +2 more sources

Palmitic acid-induced cell death: impact of endoplasmic reticulum and oxidative stress, mitigated by L-citrulline [PDF]

Animal Bioscience
Objective Palmitic acid (PA), the most abundant saturated free fatty acids, induces apoptosis in bovine mammary epithelial cells (MECs). It is suggested that oxidative stress and endoplasmic reticulum (ER) stress are key mechanisms underlying PA-induced ...
Md. Rezwanul Habib, Yukako Tokutake, Shinichi Yonekura   +2 more
doaj   +2 more sources

Oral administration of l-citrulline alters the vascular delivery of substances to rat skeletal muscles

Biochemistry and Biophysics Reports, 2021
Vascular endothelial function deteriorates with age and disease, and the production of vasodilator factors like nitric oxide (NO) decreases. The free amino acid l-citrulline increases vasodilation and blood flow through increased NO production.
Sho Miyatake, Kazuo Hino, Goro Ebisu, Satoshi Fujita   +3 more
doaj   +1 more source

Impact of l‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells

Pulmonary Circulation, 2023
Impaired nitric oxide (NO) signaling contributes to the development of pulmonary hypertension (PH). The l‐arginine precursor, l‐citrulline, improves NO signaling and has therapeutic potential in PH.
Matthew S. Douglass, Mark R. Kaplowitz, Yongmei Zhang, Candice D. Fike   +3 more
doaj   +1 more source

Anti-nociceptive Activity of L-citrulline in Mice Using Formalin and Hot Plate Tests: Possible Mechanism of Action [PDF]

Avicenna Journal of Medical Biochemistry, 2022
Background: Peripheral pain regulation is a very complex phenomenon due to the numerous neural pathways responsible for it. Objectives: The current study aimed to determine the anti-nociceptive activity of L-citrulline and the possible role of ...
Pegah Haramipour, Shahin Hassanpour
doaj   +1 more source