Results 1 to 10 of about 309,745 (119)

L-Arginine as an Adjuvant Chemosensitizer: Enhancement of Intestinal Permeability and Cytotoxic Activity of Doxorubicin [PDF]

Pharmaceuticals
Background/Objectives: Doxorubicin is an anthracycline chemotherapeutic agent widely used in the treatment of breast cancer. However, its clinical utility is limited by the drug’s resistance development, low oral bioavailability, and dose-dependent side ...
Ghada Saad, Rana M. Alquwayi, Hanin B. Alanazi, Farah B. Aldahmashi, Aryam M. Alahmary, Shouq K. Almutairi, Fatima R. Alshammari, Ghadah T. Alshammari, Afnan J. Alrashidi, Norah K. Aldousari, Haifa F. Alsubiei, Lama H. Alanazi, Meaad H. Aldossary, Amal A. Sultan   +13 more
doaj   +2 more sources

Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism

BMJ Open Respiratory Research, 2023
Background The L-arginine metabolome is dysregulated in asthma, though it is not understood how longitudinal changes in L-arginine metabolism differ among asthma phenotypes and relate to disease outcomes.Objectives To determine the longitudinal ...
Alex Federman, Ryan Peterson, Ying Jin, Sunita Sharma, Fernando Holguin, Hartmut Grasemann, Meghan Dolan Althoff, Max McGrath, Juan Pablo Wisnivesky   +8 more
doaj   +1 more source

A novel strategy for l-arginine production in engineered Escherichia coli

Microbial Cell Factories, 2023
Background l-arginine is an important amino acid with applications in diverse industrial and pharmaceutical fields. n-acetylglutamate, synthesized from l-glutamate and acetyl-CoA, is a precursor of the l-arginine biosynthetic branch in microorganisms ...
Mengzhen Nie, Jingyu Wang, Kechun Zhang
doaj   +1 more source

Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon

Sports, 2021
Endothelial vasodilatory function is dependent on the NO synthesis from L-arginine by endothelial NO-synthetase (eNOS). eNOS can be inhibited by asymmetric dimethylarginine (ADMA) by competitive inhibition on the binding site, and symmetric ...
Christoffer Nyborg, Martin Bonnevie-Svendsen, Helene Støle Melsom, Jørgen Melau, Ingebjørg Seljeflot, Jonny Hisdal   +5 more
doaj   +1 more source

Pentadecapeptide BPC 157 Reduces Bleeding and Thrombocytopenia after Amputation in Rats Treated with Heparin, Warfarin, L-NAME and L-Arginine. [PDF]

PLoS ONE, 2015
BPC 157 is a stable gastric pentadecapeptide recently implicated with a role in hemostasis. While NO is largely implicated in hemostatic mechanisms, in tail-amputation-models under heparin- and warfarin-administration, both the NO-synthase (NOS)-blocker,
Mirjana Stupnisek, Antonio Kokot, Domagoj Drmic, Masa Hrelec Patrlj, Anita Zenko Sever, Danijela Kolenc, Bozo Radic, Jelena Suran, Davor Bojic, Aleksandar Vcev, Sven Seiwerth, Predrag Sikiric   +11 more
doaj   +1 more source

Detrimental Effects of Chronic L-Arginine Rich Food on Aging Kidney

Frontiers in Pharmacology, 2021
The impaired L-arginine/nitric oxide pathway is a well-recognized mechanism for cardiovascular and renal diseases with aging. Therefore, supplementation of L-arginine is widely proposed to boost health or as adjunct therapy for the patients.
Ji Huang, Ji Huang, Diogo Ladeiras, Diogo Ladeiras, Yi Yu, Xiu-Fen Ming, Xiu-Fen Ming, Zhihong Yang, Zhihong Yang   +8 more
doaj   +1 more source

L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL

Transplantation Reports, 2022
Background: The small intestine is one of the most sensitive organs to ischemia. L-arginine has been shown to reduce damage from ischemia and reperfusion injury.
Michele Finotti, Maria Barahona, Renee M. Maina, Taras Lysyy, Raghav Agarwal, Phillip Schmitt, Giorgio Caturegli, Chiara Di Renzo, Alessandro Anselmo, David Mulligan, John P. Geibel, Francesco D'Amico   +11 more
doaj   +1 more source

BPC 157, L-NAME, L-Arginine, NO-Relation, in the Suited Rat Ketamine Models Resembling “Negative-Like” Symptoms of Schizophrenia

Biomedicines, 2022
We attempted throughout the NO-system to achieve the particular counteraction of the ketamine-induced resembling “negative-like” schizophrenia symptoms in rats using pentadecapeptide BPC 157, and NO-agents, NG-nitro-L-arginine methylester (L-NAME), and ...
Andrea Zemba Cilic, Mladen Zemba, Matija Cilic, Sanja Strbe, Spomenko Ilic, Jaksa Vukojevic, Zoran Zoricic, Igor Filipcic, Antonio Kokot, Ivan Maria Smoday, Iva Rukavina, Alenka Boban Blagaic, Ante Tvrdeic, Bozidar Duplancic, Vasilije Stambolija, Darko Marcinko, Anita Skrtic, Sven Seiwerth, Predrag Sikiric   +18 more
doaj   +1 more source

Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803

BMC Genomics, 2007
Background So far very limited knowledge exists on L-arginine catabolism in cyanobacteria, although six major L-arginine-degrading pathways have been described for prokaryotes.
Pistorius Elfriede K, Staiger Dorothee, Rückert Christian, Schriek Sarah, Michel Klaus-Peter   +4 more
doaj   +1 more source

Carcass Percentage of Laying Ducks (Anas platyrhyncos) Supplemented by L-Arginine in Ration and Treated by L-Arginine In-Ovo Injection

Tropical Animal Science Journal, 2019
This study aimed to measure the effect of L-Arginine supplementation in the ration of laying duck and in-ovo injection of L-Arginine during egg incubation on breast muscle dimensions and carcass percentage of local duck.
Syahruddin Syahruddin, L. Agustina, W. Pakiding, R. Malaka   +3 more
doaj   +1 more source