L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism. [PDF]
PLoS ONE, 2015 Dietary L-citrulline is thought to modulate muscle protein turnover by increasing L-arginine availability. To date, the direct effects of increased L-citrulline concentrations in muscle have been completely neglected. Therefore, we determined the role of
Daniel J Ham +6 more
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l-Citrulline dilates rat retinal arterioles via nitric oxide- and prostaglandin-dependent pathways in vivo [PDF]
Journal of Pharmacological Sciences, 2015 l-Citrulline is an effective precursor of l-arginine produced by the l-citrulline/l-arginine cycle, and it exerts beneficial effects on the cardiovascular system by supporting enhanced nitric oxide (NO) production.
Asami Mori +5 more
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L-Arginine and L-Citrulline Supplementation Have Different Programming Effect on Regulatory T-Cells Function of Infantile Rats [PDF]
Frontiers in Immunology, 2018 Arginine is a semiessential amino acid in healthy adult human, but is essential for preterm, newborn or critically ill patients. Arginine can be supplied from our diet or de novo synthesis from citrulline. In conditions of sepsis or endotoxemia, arginine
Yi-Chen Lee +5 more
doaj +2 more sources
L-citrulline supplementation reverses the impaired airway relaxation in neonatal rats exposed to hyperoxia [PDF]
Respiratory Research, 2012 Background Hyperoxia is shown to impair airway relaxation via limiting L-arginine bioavailability to nitric oxide synthase (NOS) and reducing NO production as a consequence. L-arginine can also be synthesized by L-citrulline recycling.
Sopi Ramadan B +7 more
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Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence. [PDF]
PLoS ONE, 2018 L-citrulline and L-arginine supplementation has been shown to have several beneficial effects on the cardiovascular system. Nitric oxide (NO) protects against the progression of atherosclerosis and is synthesized by nitric oxide synthase (NOS), which ...
Tomoe Tsuboi +2 more
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International Journal of Analytical Chemistry, 2018 Watermelons (Citrullus lanatus) are known to have sufficient amino acid content. In this study, watermelons grown and consumed in Malaysia were investigated for their amino acid content, L-citrulline and L-arginine, by the isocratic RP-HPLC method. Flesh
Rasdin Ridwan +3 more
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The effect of L-citrulline ingestion on cardiovascular function
, 2015 Background: there has been evidence that has suggested that the L-citrulline is readily converted to L- arginine, as the main substrate for nitric oxide (NO) production, thus enhancing the NO levels has shown to improve endothelial dysfunction and ...
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Pulmonary Circulation, 2021 The L-arginine precursor, L-citrulline, re-couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Matthew S. Douglass +3 more
doaj +1 more source
Sodium-coupled neutral amino acid transporter 1 (SNAT1) modulates L-citrulline transport and nitric oxide (NO) signaling in piglet pulmonary arterial endothelial cells. [PDF]
PLoS ONE, 2014 There is evidence that impairments in nitric oxide (NO) signaling contribute to chronic hypoxia-induced pulmonary hypertension. The L-arginine-NO precursor, L-citrulline, has been shown to ameliorate pulmonary hypertension.
Anna Dikalova +5 more
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Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. [PDF]
PLoS ONE, 2012 BACKGROUND: Impaired microcirculation during endotoxemia correlates with a disturbed arginine-nitric oxide (NO) metabolism and is associated with deteriorating organ function.
Karolina A P Wijnands +6 more
doaj +1 more source