Results 41 to 50 of about 34,707 (264)

Manipulation of citrulline availability in humans [PDF]

, 2007
International audienceTo determine whether circulating citrulline can be manipulated in vivo in humans, and, if so, whether citrulline availability affects the levels of related amino acids, nitric oxide, urinary citrulline, and urea nitrogen, 10 healthy
Des Robert, Clotilde, Robins, Alexander, Rougé, Carole, Darmaun, Dominique, Le Bacquer, Olivier, Volteau, Christelle, de la Cochetière, Marie-France   +6 more
core   +1 more source

Citrulline: from metabolism to therapeutic use.: citrulline: metabolism and therapeutic [PDF]

, 2013
International audienceCitrulline possesses a highly specific metabolism that bypasses splanchnic extraction because it is not used by the intestine or taken up by the liver.
Cynober, Luc, Crenn, Pascal, Curis, Emmanuel, Sfar, Souad, Aussel, Christian, Chaumeil, Jean-Claude, Moinard, Christophe, Bahri, Senda, Zerrouk, Naima   +8 more
core   +2 more sources

Citrulline Evaluation in Bowel Transplantation [PDF]

, 2010
The purpose of this study was to evaluate the correlation of plasma citrulline and rejection episodes in intestinal transplantation. From January 2007 until present, we performed citrulline assays on our small bowel patients.
Tryphonopoulos, P, Island, E, Nishida, S, Defranc, T, Levi, D, Tekin, A, Berlanga, A, Selvaggi, G, Tzakis, A.G, Ruiz, P, Moon, J   +10 more
core   +1 more source

Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome. [PDF]

PLoS ONE, 2013
In humans, plasma amino acid concentrations of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) increase in states of obesity, insulin resistance and diabetes.
Manuela Sailer, Christoph Dahlhoff, Pieter Giesbertz, Mena K Eidens, Nicole de Wit, Isabel Rubio-Aliaga, Mark V Boekschoten, Michael Müller, Hannelore Daniel   +8 more
doaj   +1 more source

Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak.

PLoS ONE, 2019
Clinical and model studies indicate that low nitric oxide (NO) bioavailability due in part to profound hypoargininemia contributes to cerebral malaria (CM) pathogenesis.
Irene Gramaglia, Joyce Velez, Yu-Sun Chang, Wilson Caparros-Wanderley, Valery Combes, Georges Grau, Monique F Stins, Henri C van der Heyde   +7 more
doaj   +1 more source

L-citrulline supplementation reverses the impaired airway relaxation in neonatal rats exposed to hyperoxia

Respiratory Research, 2012
Background Hyperoxia is shown to impair airway relaxation via limiting L-arginine bioavailability to nitric oxide synthase (NOS) and reducing NO production as a consequence. L-arginine can also be synthesized by L-citrulline recycling.
Sopi Ramadan B, Zaidi Syed IA, Mladenov Mitko, Sahiti Hazbije, Istrefi Zahide, Gjorgoski Icko, Lajçi Azem, Jakupaj Muharrem   +7 more
doaj   +1 more source

Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. [PDF]

PLoS ONE, 2012
BACKGROUND: Impaired microcirculation during endotoxemia correlates with a disturbed arginine-nitric oxide (NO) metabolism and is associated with deteriorating organ function.
Karolina A P Wijnands, Hans Vink, Jacob J Briedé, Ernst E van Faassen, Wouter H Lamers, Wim A Buurman, Martijn Poeze   +6 more
doaj   +1 more source

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Rikard Holmdahl, Bockermann, Robert, Hüseyin Uysal, Sehnert, Bettina,, Harald Burkhardt, Robert Bockermann, Bockermann, R, Nandakumar, Kutty S, Bajtner, Estelle,, Engstrom, A, Thunnissen, Marjolein M G M, Uysal, H,, Serre, Guy, Serre, G, Holmdahl, R,, Nandakumar, Kutty Selva,, Bajtner, E, Holmdahl, Rikard, Uysal, Hüseyin,, Burkhardt, Harald,, Burkhardt, H, Kutty Selva, Nandakumar,, Kutty S. Nandakumar, Bettina Sehnert, Thunnissen, MMGM, Serre, Guy,, Nandakumar, Kutty S., Burkhardt, Harald, Engström, Åke, Thunnissen, Marjolein,, Guy Serre, Engström, Åke,, Thunnissen, Marjolein M. G. M., Thunnissen, Marjolein M. G. M.,, Sehnert, B, Åke Engström, Sehnert, Bettina, Kutty Selva, Nandakumar, Nandakumar, KS, Estelle Bajtner, Lund University., Bajtner, Estelle, Thunnissen, Marjolein, Marjolein M.G.M. Thunnissen, Bockermann, Robert,, Holmdahl, Rikard,, Uysal, Hüseyin   +46 more
core   +1 more source

L-Citrulline Supplementation Reduces Blood Pressure and Myocardial Infarct Size under Chronic Intermittent Hypoxia, a Major Feature of Sleep Apnea Syndrome

Antioxidants, 2022
Intermittent hypoxia (IH) is a landmark of obstructive sleep apnea (OSA) at the core of the cardiovascular consequences of OSA. IH triggers oxidative stress, a major underlying mechanism for elevated blood pressure (BP) and increased infarct size.
Bilgehan Ozcan, Britanny Blachot-Minassian, Stéphanie Paradis, Lucile Mazière, Marie Chambion-Diaz, Sophie Bouyon, Jean-Louis Pépin, Vincent Pialoux, Claire Arnaud, Christophe Moinard, Elise Belaidi   +10 more
doaj   +1 more source

Source and fate of circulating citrulline [PDF]

, 1981
Previous work has demonstrated a continuous release of citrulline from the small intestine into the circulation. To evaluate the physiologic significance of this process, we have now measured citrulline uptake and release by isolated, perfused livers and,
H. G. Windmueller, A. E. Spaeth
core   +1 more source