Results 51 to 60 of about 37,088 (271)

Desenvolvimento de metodologia analítica por cromatografia líquida de alta eficiência e eletroforese capilar para análise de citrulina em matrizes biológicas: Ana Claudia Vieira; orientador, Flavio Henrique Reginatto. [PDF]

, 2014
A intensa busca por novos biomarcadores de doenças com intuito de melhorar o diagnóstico e acompanhar a evolução da doença tem feito os pesquisadores reavaliar compostos antes ignorados, como a citrulina.
Vieira, Ana Claudia
core  

Evaluation of anti-diarrhoeal activity of L-citrulline in mice [PDF]

, 2019
Background: L-citrulline is a naturally occurring physiological non-essential amino acid that plays an important role in the metabolism and regulation of nitric oxide.
Saminu, S, Farra’u, U, Abdulwahab, A, Babale, A.I., Saleh, M.I.A.   +4 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Manipulation of citrulline availability in humans

, 2007
International audienceTo determine whether circulating citrulline can be manipulated in vivo in humans, and, if so, whether citrulline availability affects the levels of related amino acids, nitric oxide, urinary citrulline, and urea nitrogen, 10 healthy
Des Robert, Clotilde, Robins, Alexander, Rougé, Carole, Darmaun, Dominique, Le Bacquer, Olivier, Volteau, Christelle, de la Cochetière, Marie-France   +6 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Investigation of endocrine response of thyroid and intestinal and adipose tissues due to the addition of Moringa oleifera essential oil in diet for quails exposed to heat stress

Revista Brasileira de Zootecnia, 2023
In this study, we aimed to determine the effect of Moringa oleifera essential oil (MOEO) supplementation to rations of Japanese quail ( Coturnix coturnix japonica ) grown under heat stress (HS) on some adipokine (visfatin, adiponectin, and chemerin ...
Bülent Bayraktar, Emre Tekce, Sevil Bayraktar, Gülbahar Böyük, Çiğdem Takma, Vecihi Aksakal, Murat Genç, Hacer Kaya, Ufuk Ülker, Ahmet Burak Gürbüz   +9 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma

Pteridines, 2021
The aim of this study was to investigate the changes in circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during the course of chemoradiation in patients with cervical cancer.
Pospíšková Markéta, Strouhal Ondřej, Hlídková Eva, Vlachová Zuzana, Melichar Bohuslav, Doležel Martin   +5 more
doaj   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

l-Citrulline ameliorates cerebral blood flow during cortical spreading depression in rats: Involvement of nitric oxide- and prostanoids-mediated pathway

Journal of Pharmacological Sciences, 2017
l-Citrulline is a potent precursor of l-arginine, and exerts beneficial effect on cardiovascular system via nitric oxide (NO) production. Migraine is one of the most popular neurovascular disorder, and imbalance of cerebral blood flow (CBF) observed in ...
Yuki Kurauchi, Koichi Mokudai, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Masahiko Morita, Ayako Kamimura, Kunio Ishii   +7 more
doaj   +1 more source