Results 51 to 60 of about 34,606 (279)

Role of antibiotic use, plasma citrulline and blood microbiome in advanced non-small cell lung cancer patients treated with nivolumab

Journal for ImmunoTherapy of Cancer, 2019
Background Recent data suggested a role of gut microbiota and antibiotic use on immune checkpoint inhibitors efficacy. We aimed to evaluate the impact of early use of antibiotic (EUA), blood microbiome and plasmatic citrulline (marker of the intestinal ...
Julia Ouaknine Krief, Pierre Helly de Tauriers, Coraline Dumenil, Nathalie Neveux, Jennifer Dumoulin, Violaine Giraud, Sylvie Labrune, Julie Tisserand, Catherine Julie, Jean-François Emile, Thierry Chinet, Etienne Giroux Leprieur   +11 more
doaj   +1 more source

Citrullination of Self‐Proteins and Autoimmunity [PDF]

Scandinavian Journal of Immunology, 2004
AbstractCitrullination (deimination is an enzymatic, posttranslational conversion of arginine residues to citrulline residues) of joint‐associated self‐proteins may be a possible mechanism in the induction of autoimmune CD4 T‐cell responses in rheumatoid arthritis.
B, Rubin, G, Sønderstrup
openaire   +2 more sources

Citrulline: from metabolism to therapeutic use.: citrulline: metabolism and therapeutic

, 2013
International audienceCitrulline possesses a highly specific metabolism that bypasses splanchnic extraction because it is not used by the intestine or taken up by the liver.
Cynober, Luc, Crenn, Pascal, Curis, Emmanuel, Sfar, Souad, Aussel, Christian, Chaumeil, Jean-Claude, Moinard, Christophe, Bahri, Senda, Zerrouk, Naima   +8 more
core   +1 more source

Metabolic and Transcriptional Regulation of Citrulline in Watermelon [PDF]

, 2021
Citrulline is a non-protein amino acid synthesized from ornithine and carbamoyl phosphate in plants. Experiments were performed to understand, (1) the partitioning of citrulline in watermelon plants during the development, (2) impact of environmental ...
Song, Qiushuo
core  

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

Autoantibodies to Joint‐Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Arthritis &Rheumatology, EarlyView.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA ...
Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää‐Dahlqvist   +12 more
wiley   +1 more source

Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells)

Journal of Biomedical Science, 2017
Background L-Citrulline is a neutral amino acid and a major precursor of L-arginine in the nitric oxide (NO) cycle. Recently it has been reported that L-citrulline prevents neuronal cell death and protects cerebrovascular injury, therefore, L-citrulline ...
Kyeong-Eun Lee, Young-Sook Kang
doaj   +1 more source

L-Citrulline Supplementation Reduces Blood Pressure and Myocardial Infarct Size under Chronic Intermittent Hypoxia, a Major Feature of Sleep Apnea Syndrome

Antioxidants, 2022
Intermittent hypoxia (IH) is a landmark of obstructive sleep apnea (OSA) at the core of the cardiovascular consequences of OSA. IH triggers oxidative stress, a major underlying mechanism for elevated blood pressure (BP) and increased infarct size.
Bilgehan Ozcan, Britanny Blachot-Minassian, Stéphanie Paradis, Lucile Mazière, Marie Chambion-Diaz, Sophie Bouyon, Jean-Louis Pépin, Vincent Pialoux, Claire Arnaud, Christophe Moinard, Elise Belaidi   +10 more
doaj   +1 more source

Citrulline Evaluation in Bowel Transplantation

, 2010
The purpose of this study was to evaluate the correlation of plasma citrulline and rejection episodes in intestinal transplantation. From January 2007 until present, we performed citrulline assays on our small bowel patients.
Tryphonopoulos, P, Island, E, Nishida, S, Defranc, T, Levi, D, Tekin, A, Berlanga, A, Selvaggi, G, Tzakis, A.G, Ruiz, P, Moon, J   +10 more
core   +1 more source

Autoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.

Arthritis &Rheumatology, Accepted Article.
Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source