Results 71 to 80 of about 37,088 (271)

Was citrulline first a laxative substance? The truth about modern citrulline and its isolation [PDF]

, 2011
Citrulline is a non-protein amino acid and is produced by the enterocytes of the small bowel. The isolation though of citrulline is generally ascribed to the 1930s.
Fragkos, K, Forbess, A
core  

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Source and fate of circulating citrulline

, 1981
Previous work has demonstrated a continuous release of citrulline from the small intestine into the circulation. To evaluate the physiologic significance of this process, we have now measured citrulline uptake and release by isolated, perfused livers and,
H. G. Windmueller, A. E. Spaeth
core   +1 more source

Endotoxemia affects citrulline, arginine and glutamine bioavailability

, 2011
International audienceBACKGROUND:Sepsis considerably alters the intestinal barrier functions, which in turn modify the absorption and bioavailability of nutrients.
Philippe Arnaud, Luc Cynober, Curis, Emmanuel, Arnaud, Philippe, Fatimazahra Elwafi, Chaumeil, Jean-Claude, Jean-Claude Chaumeil, Naima Zerrouk, Moinard, Christophe, C., Cynober, Luc, Elwafi, Fatimazahra, Neveux, Nathalie, Nathalie Neveux, Zerrouk, Naima, Moinard, Christophe,, Christophe Moinard, Emmanuel Curis   +16 more
core   +1 more source

Autoantibodies to Joint‐Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Arthritis &Rheumatology, EarlyView.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA ...
Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää‐Dahlqvist   +12 more
wiley   +1 more source

Correlation Between Parenteral Nutrition and Citrulline Levels of Pediatric Patients Who Underwent Surgery for Intestinal Disorders in Indonesia

The Korean Journal of Gastroenterology
Background/Aims: Parenteral nutrition is often administered after a small bowel resection, but it can increase the risk of complications such as sepsis and organ disorders.
Soehalino, Alpha Fardah Athiyyah, Reza Gunadi Ranuh, Andy Darma, Subijanto Marto Sudarmo, Khadijah Rizky Sumitro   +5 more
doaj   +1 more source

Citrulline and Skeletal Muscle

, 2019
International audienceCitrulline is a nonessential amino acid with properties that were unknown or largely ignored until the last decade when it began to arouse the interest of scientists due to its key role in the regulation of nitrogen homeostasis.
Breuillard, Charlotte, Charlotte Breuillard, Arthur Goron, Moinard, Christophe, Goron, Arthur, Christophe Moinard   +5 more
core   +1 more source

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

Arthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

The effect of L-citrulline ingestion on cardiovascular function

, 2015
Background: there has been evidence that has suggested that the L-citrulline is readily converted to L- arginine, as the main substrate for nitric oxide (NO) production, thus enhancing the NO levels has shown to improve endothelial dysfunction and ...

core   +6 more sources