Results 91 to 100 of about 37,088 (271)

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara   +20 more
wiley   +1 more source

Thẩm định quy trình định lượng L-citrulline trong một số loại dưa hấu bằng phương pháp UV-Vis

open access: yesTạp chí Khoa học Đại học Cần Thơ
Dưa hấu là một loại trái cây giàu L-citrulline, đặc biệt là trong vỏ quả, L-citrulline giúp cải thiện sức khỏe tim mạch, tăng cường miễn dịch và các lợi ích về sức khỏe tình dục.
Vi Nhã Trân   +6 more
doaj   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

open access: yesDevelopmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble   +2 more
wiley   +1 more source

Intestinal and hepatic metabolism of glutamine and citrulline in humans

open access: yes, 2007
Glutamine plays an important role in nitrogen homeostasis and intestinal substrate supply. It has been suggested that glutamine is a precursor for arginine through an intestinal-renal pathway involving interorgan transport of citrulline.
Boelens, P.G.   +5 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

open access: yesEpilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Citrulline, a potential biomarker of radiation-induced small intestine damage

open access: yes, 2020
Radiation damage assessment of the small intestine is important in nuclear accidents or routine radiotherapy of abdominal tumors. This article reviews the clinical symptoms and molecular mechanisms of radiation-induced small intestinal damage and ...
1016292   +16 more
core   +1 more source

Monitoring and Mitigation Strategies for Hazardous Compounds in Chinese Rice Wine (Huangjiu): A Comprehensive Review

open access: yesFood Safety and Health, EarlyView.
This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu   +5 more
wiley   +1 more source

The effect of endurance resistance exercise combined with L­citrulline malate supplement on FGF, VEGF, and fatigue among young bodybuilders [PDF]

open access: yesفصلنامه ابن سینا, 2019
Background: Citrulline malate is a non-essential alpha-amino acid supplement resulting from arginine oxidation and may cause changes in the immunity, cardiovascular, and angiogenic mechanisms. It also reduces the rating of fatigue perception. The purpose
farah nameni   +1 more
doaj  

Gut Microbiota Modulation and Functional Effects of Edible and Medicinal Fungi: Sanghuangporus vaninii as a Case Study

open access: yesGut Medicine, EarlyView.
ABSTRACT Edible and medicinal fungi exert diverse biological effects, including immunomodulatory, antitumour, and anti‐inflammatory activities, as well as the amelioration of metabolic disorders. The relationship between these effects and the gut microbiota is attracting increasing attention.
Meng Teng, Wenqi Li, Di Wang, Lanzhou Li
wiley   +1 more source

Urinary and Faecal Amino‐Acids as Biomarkers for Colorectal Neoplasia in Lynch Syndrome—A Prospective Longitudinal Study

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT In Lynch syndrome, colonoscopy surveillance for colorectal cancer (CRC) is burdensome and post‐colonoscopy CRCs still occur. Unlike the faecal immunochemical test (FIT), gut metabolomic alterations including amino‐acids have shown potential as non‐invasive biomarkers for detecting both advanced and non‐advanced sporadic colorectal neoplasia ...
Roza C. M. Opperman   +18 more
wiley   +1 more source

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